Results 91 to 100 of about 1,834,359 (305)

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

Molecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla, Jan Kosla, Magdalena Prechova, Lukas Frick, Patricia Bortel, Yasmin Borutzki, Andrea Bileck, Christopher Gerner, Samuel M. Meier‐Menches, Selma Osmanagic‐Myers, Martin Gregor   +10 more
wiley   +1 more source

Analysis of the Literature on Emergency Department Throughput

Western Journal of Emergency Medicine, 2009
Introduction: The purpose of this paper was to review and analyze all the literature concerning ED patient throughput. The secondary goal was to determine if certain factors would significantly alter patients’ ED throughput.Methods: A MEDLINE search was ...
Zun, Leslie S
doaj  

Postpartum length of hospital stay among obstetric patients in Ibadan, Nigeria

BMC Health Services Research
Background Postpartum Length of hospital stay (PLOHS) is an essential indicator of the quality of maternal and perinatal healthcare services. Identifying the factors associated with PLOHS will inform targeted interventions to reduce unnecessary ...
Ikeola A. Adeoye, Blessing U. Aleka, Rotimi F. Afolabi, Timothy A.O Oluwasola   +3 more
doaj   +1 more source

Epidemiology of intensive care unit-acquired sepsis in Italy: results of the SPIN-UTI network [PDF]

, 2018
BACKGROUND: Sepsis is the major cause of mortality from any infectious disease worldwide. Sepsis may be the result of a healthcare associated infection (HAI): the most frequent adverse events during care delivery especially in Intensive Care Units ...
Agodi A, Arrigoni C, Auxilia F, Barchitta M, Brusaferro S, D'Errico MM, Fabiani L, Laurenti P, Mattaliano AR, Montagna MT, Mura I, Orsi GB, Pasquarella C, Squeri R, Tardivo S, Torregrossa MV   +15 more
core   +1 more source

Therapeutic strategies for MMAE‐resistant bladder cancer through DPP4 inhibition

Molecular Oncology, EarlyView.
We established monomethyl auristatin E (MMAE)‐resistant bladder cancer (BC) cell lines by exposure to progressively increasing concentrations of MMAE in vitro. RNA sequencing showed DPP4 expression was increased in MMAE‐resistant BC cells. Both si‐DPP4 and the DPP4 inhibitor sitagliptin suppressed the viability of MMAE‐resistant BC cells.
Gang Li, Shuichi Tatarano, Hirofumi Yoshino, Saeki Saito, Mitsuhiko Tominaga, Junya Arima, Ikumi Fukuda, Takashi Sakaguchi, Ryosuke Matsushita, Yasutoshi Yamada, Hideki Enokida   +10 more
wiley   +1 more source

Determinants of Length of Stay: A Parametric Survival Analysis [PDF]

, 2013
Copyright © 2011 Cognizant Comm. Corp.Length of stay is one of the most important decisions made by tourists as it conditions their overall expenditure and stress caused on local resources.
Menezes, António Gomes de, Moniz, Ana Isabel Arruda   +1 more
core   +1 more source

Recurrent cancer‐associated ERBB4 mutations are transforming and confer resistance to targeted therapies

Molecular Oncology, EarlyView.
We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala, Sini Ahonen, Sara Peltola, Aura Tuohisto‐Kokko, Olaya Esparta, Peppi Suominen, Anne Jokilammi, Iman Farahani, Deepankar Chakroborty, Nikol Dibus, Steffen Boettcher, Tomi T. Airenne, Mark S. Johnson, Lisa D. Eli, Klaus Elenius, Kari J. Kurppa   +15 more
wiley   +1 more source

Hospital Admissions, Length of Stay, and Case-Mix Impacts of Per Case Payment: The Maryland Experience [PDF]

Maryland has simultaneously operated per case - and per service hospital payment systems since 1976 with varying levels of stringency in setting per case rates.
David S. Salkever, Donald M. Steinwachs
core  

Analysis of the impact of length of stay on the quality of service experience, satisfaction and loyalty [PDF]

, 2017
Although length of stay is a relevant variable in destination management, little research has been produced connecting it with tourists' post-consumption behaviour. This research compares the post-consumption behaviour of same-day visitors with overnight
A Coghlan, A Decrop, A Esteban Talaya, A Fleischer, A Zehrer, AB Grigolon, Amparo Cervera-Taulet, B Ferrer-Rosell, C Barros, C Chen, C Thrane, Carmen Pérez-Cabañero, CG-Q Chi, D Gursoy, D LaSalle, E Alén, E Martínez-García, E Smeral, G Prayag, H Oh, J Alegre, J Alegre, J Eugenio-Martin, J Neal, J Otto, JD Neal, JE Bigne, JF Petrick, JJ Cronin, JL Crompton, JM Ramírez-Hurtado, K Astrapellos, K Ying, L Salmasi, L Su, LP Machado, M Battour, M Cordente-Rodríguez, M Fakharyan, M Kozak, M Kruger, M Meleddu, M Pulina, N Peypoch, NK Prebensen, R Oliver, R Oliver, R Spreng, R Sánchez-Fernández, S Dolnicar, S Hennessey, S Hosany, S Huang, S Lee, SA Cohen, SY Lee, T Bieger, TK Hui, U Gokovali, U Walter, V Tung, V Zabkar, VB Agarwal, W Schlesinger, Walesska Schlesinger, XR Li, Y He, Y-F Kao   +67 more
core   +2 more sources

Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity

Molecular Oncology, EarlyView.
Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung, David Bickel, Lena C. M. Krause, Daria Ezeriņa, Christian Ickes, Julian Wojtachnia, Christine S. Gibhardt, Magdalena Shumanska, Khadija Wahni, Andrea Paluschkiwitz, Julia Malo Pueyo, Ekaterina Baranova, Wim Vranken, Hedwig Stanisz, Ioana Stejerean‐Todoran, Michael P. Schön, Joris Messens, Ivan Bogeski   +17 more
wiley   +1 more source