Results 71 to 80 of about 1,156,270 (203)

Refining diagnostic boundaries and electroclinical profiles of Lennox–Gastaut syndrome through unsupervised clustering

Epilepsia, EarlyView.
Abstract Objective Lennox–Gastaut syndrome (LGS) is a developmental and epileptic encephalopathy defined by polymorphic seizures, intellectual disability (ID), and characteristic electroencephalographic (EEG) patterns. The applicability and biological validity of current electroclinical criteria remain debated.
Emanuele Cerulli Irelli, Marco Perulli, Maria S. Borioni, Anna Falco, Adolfo Mazzeo, Enrico Cocchi, Maria L. Gambardella, Alessandra Morano, Michela Quintiliani, Maria Picilli, Anna T. Giallonardo, Carlo Di Bonaventura, Domenica I. Battaglia   +12 more
wiley   +1 more source

Antiseizure potency and neurotoxicity of the enantiomers of fenfluramine and norfenfluramine in rats and correlations with their concentrations in plasma and brain

Epilepsia, EarlyView.
Abstract Objective Based on the evidence that fenfluramine‐induced anorexia, weight loss, and cardiovascular toxicity are primarily mediated by the d‐enantiomers of fenfluramine and its metabolite norfenfluramine, we investigated pharmacokinetic/pharmacodynamic correlations for the active enantiomers of fenfluramine and norfenfluramine in the rat ...
Yara Sheeni, Dinorah Barasch, Tawfeeq Shekh‐Ahmad, Emilio Perucca, Meir Bialer   +4 more
wiley   +1 more source

Lennox-Gastaut syndrome: a consensus approach on diagnosis, assessment, management, and trial methodology.

, 2009
Lennox-Gastaut syndrome is one of the most severe epileptic encephalopathies of childhood onset. The cause of this syndrome can be symptomatic (ie, secondary to an underlying brain disorder) or cryptogenic (ie, has no known cause).
Pellock JM, Arzimanoglou A, Ernst JP, Feucht M, Cross JH, Genton P, PERUCCA, EMILIO, Wheless J.W., Blume WT, French J, Guerrini R, Kluger G   +11 more
core   +1 more source

Cannabidiol per al tractament de la síndrome de Lennox-Gastaut i la síndrome de Dravet [PDF]

, 2020
Epilèpsia; Cannabidiol; Síndrome Lennox-Gastaut; Síndrome DravetEpilepsia; Cannabidiol; Síndrome Lennox-Gastaut; Síndrome DravetEpilepsy; Cannabidiol; Lennox-Gastaut Syndrome; Dravet syndromeLes síndromes de Lennox-Gastaut (SLG) i de Dravet (SD) són ...
Programa d'Harmonització Farmacoterapèutica
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Perils and progress in epilepsy surgery utilization: Twenty‐five years later

Epilepsia, EarlyView.
Abstract More than 25 years have passed since the first randomized controlled trial (RCT) established that surgery is superior to continued anti‐seizure medication (ASM) for drug‐resistant temporal lobe epilepsy, and nearly as long since a joint practice parameter urged that appropriate surgical candidates be referred to a specialized center for ...
Dario J. Englot
wiley   +1 more source

Outcomes of out‐of‐hospital treatment of impending tonic–clonic status epilepticus with diazepam nasal spray: A retrospective combined cohort analysis

Epilepsia, EarlyView.
Abstract Objective We assessed the timing, dosing, and effectiveness of diazepam nasal spray in a large dataset of seizures treated in the out‐of‐hospital setting, using as reference the International League Against Epilepsy criteria for tonic–clonic status epilepticus (SE) and its treatment.
John M. Stern, Leock Y. Ngo, Eric B. Segal, Danielle A. Becker, Randa G. Jarrar, Tracy A. Glauser, Jurriaan M. Peters, Emilio Perucca, Evelyn K. Shih, Enrique Carrazana, Adrian L. Rabinowicz   +10 more
wiley   +1 more source

Lennox-gastaut Syndrome With Good Outcome Associated With Perisylvian Polymicrogyria

, 2015
This chapter showcases a patient suffering from Lennox-Gastaut syndrome due to perisylvian polymicrogyria. The 10-year-old right-handed boy had a history of dysarthria and seizures. He started having seizures at 3 years of age.
Guerreiro M.M.
core   +1 more source

Immunological disturbance in West and Lennox-Gastaut syndromes

Arquivos de Neuro-Psiquiatria, 1984
Cell-mediated and humoral immunity were investigated in 18 patients with West syndrome, 12 with Lennox-Gastaut syndrome and 19 healthy controls. The study included determination of Ô and  peripheral blood lymphocytes, serum levels of IgG, IgA and IgM ...
Terezinha C. B. Montelli, Norma G. S. Mota, M. Terezinha S. Peraçoli, Elza A. Torres, M. Thereza Rezkallah-Iwasso   +4 more
doaj   +1 more source

A Phase I study of the pharmacokinetics (PK), bioavailability, dose proportionality, safety, and tolerability of topiramate injection compared to Oral topiramate in healthy adult participants

Epilepsia, EarlyView.
Abstract This Phase I study evaluated the safety, tolerability, and pharmacokinetics of a 30‐min topiramate injection (intravenous [IV] TPM) infusion compared with oral topiramate (oral TPM) in healthy adult participants. In this randomized, open‐label, dose escalation, crossover study with 37 healthy participants received single doses of 50, 100, or ...
Adeboye O. Bamgboye, James C. Cloyd, Bernard D. King, Lisa D. Coles   +3 more
wiley   +1 more source

New antiepileptic drugs in the treatment of Lennox-Gastaut syndrome [PDF]

, 2010
Lennox–Gastaut syndrome is a childhood epileptic encephalopathy characterised by polymorphic seizures and neuropsychological decline. The most characteristic seizures are tonic fits, atypical absences and atonic seizures, in that order. Treatment options
COPPOLA, Giangennaro, G. COPPOLA, ALBERTO VERROTTI, HOW TO, CLAUDIA DEGIDIO, GIULIA LOIACONO, LUCIA FIORDALISO   +6 more
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