Results 1 to 10 of about 19,789 (243)

Lamotrigine serum concentrations as longitudinal biomarkers for seizure risk prediction in pregnant women with epilepsy: a secondary analysis of the EMPiRE study [PDF]

BMJ Neurology Open
Background Serum lamotrigine concentrations fall during pregnancy, and therapeutic drug monitoring is often used to guide dose adjustment. We do not know whether serial antenatal measurements improve prediction of seizure risk in pregnant women with ...
Shakila Thangaratinam, Javier Zamora, Teresa Pérez, John Allotey, Fatima Junaid, Valeria Rolle, María del Carmen Pardo   +6 more
doaj   +2 more sources

Fosphenytoin may be effective in shortening the half-life of lamotrigine in case of overdose: a case report [PDF]

Journal of Medical Case Reports
Background This case study highlights the efficacy of fosphenytoin in managing cardiac arrest and seizures caused by lamotrigine overdose. While activated charcoal and sodium bicarbonate are typically recommended for lamotrigine overdose, alternative ...
Jun Sato, Shingo Ihara, Tsukasa Kuwana, Masao Sekimoto, Yuto Suzuki, Katsuhiro Nakagawa, Nobutaka Chiba, Takeshi Saito, Kosaku Kinoshita   +8 more
doaj   +2 more sources

Case report: Progressive skin rash and lymphadenopathy associated with lamotrigine−valproic acid combination in a bipolar adolescent

Frontiers in Pharmacology, 2023
Background: Lamotrigine may cause severe skin reactions. There is a known interaction between lamotrigine and valproic acid with an increase in lamotrigine levels and lamotrigine toxicity risk.
Yingxu Duan, Fangxinrui Qiu, Jingyuan Zhou, Shiyu Liu, Die Zhao, Changjian Qiu   +5 more
doaj   +1 more source

Assessing efficacy and tolerability of lamotrigine (Sazar®) in therapy of female idiopathic generalized epilepsy: a multicenter study

Эпилепсия и пароксизмальные состояния, 2022
Background. Idiopathic generalized epilepsy (IGE) comprises 15–20% among all types of epilepsy. However, specifics of administration for lamotrigine in IGE in the Russian Federation remain poorly investigated, especially in female subjects.Objective: to ...
M. V. Barkhatov, I. S. Bakhtin, O. V. Belyaev, M. A. Yamin   +3 more
doaj   +1 more source

Liver dysfunction induced by systemic hypersensitivity reaction to lamotrigine: case report [PDF]

Clinical and Molecular Hepatology, 2015
Lamotrigine is an anticonvulsant drug used to treat partial and generalized seizure disorders. Hypersensitivity to lamotrigine usually causes mild symptoms such as fever, rash, and slight invasion of internal organs.
Sung Gyu Im, Sun Hong Yoo, Young Min Park, Sang Jin Lee, Sun Kyung Jang, Dong Ok Jeon, Hyo Jin Cho, Mi Jung Oh   +7 more
doaj   +1 more source

Is ketamine and lamotrigine interactions responsible for the sub-therapeutic effect of ketamine?

European Psychiatry, 2021
Introduction The immediate antidepressant effect of Ketamine has become a breakthrough in the treatment of depression. Cytochrome CYP3A4 and 2B6 primarily metabolize Ketamine.
M. Adnan, F. Motiwala, Z. Mansuri, C. Trivedi, A. Reddy   +4 more
doaj   +1 more source

Pharmacokinetic, pharmacodynamic, and neurochemical investigations of lamotrigine‐pentylenetetrazole kindled mice to ascertain it as a reliable model for clinical drug‐resistant epilepsy

Animal Models and Experimental Medicine, 2020
Background Pentylenetetrazole kindling has long been used for the screening of investigational antiseizure drugs. The presence of lamotrigine, at a very low dose, does not hamper kindling in mice; rather it modifies this epileptogenesis process into drug‐
Sandeep Kumar, Rajesh K. Goel
doaj   +1 more source

Ketamine and Lamotrigine Combination in Psychopharmacology: Systematic Review

Cells, 2022
Background and Objectives: Ketamine is a rapid-acting antidepressant with proven efficacy as an add-on agent in unipolar and bipolar treatment-resistant depression.
Alina Wilkowska, Mariusz S. Wiglusz, Katarzyna Jakuszkowiak-Wojten, Wiesław J. Cubała   +3 more
doaj   +1 more source

Action Tremor Associated with Lamotrigine Monotherapy [PDF]

Journal of Movement Disorders, 2010
Lamotrigine (LTG) is associated with a tremor when given in combination with valproic acid; however, a tremor associated with lamotrigine monotherapy is rare. Here, we report a case of positional and action tremor associated with lamotrigine use.
Ji-Hye Yang, Sung-Woo Chung, Joong-Seok Kim   +2 more
doaj   +1 more source

May lamotrigine be an alternative to topiramate in the prevention of migraine with aura? Results of a retrospective study

BMJ Neurology Open, 2020
Background Evidence suggests that lamotrigine could be effective in reducing aura frequency and duration. However, studies comparing lamotrigine to other, first-line prophylactic agents solely involving patients suffering from migraine with aura are ...
Francesco Janes, Carmelo Luca Smeralda, Gian Luigi Gigli, Mariarosaria Valente   +3 more
doaj   +1 more source