Results 21 to 30 of about 20,608 (229)

Adherence to and persistence with lacosamide, perampanel, lamotrigine, and levetiracetam in adult patients with focal epilepsy in Japan: A descriptive cohort study using a claims database

Heliyon, 2023
Objective: We evaluated adherence to and 1-year persistence of two third-generation anti-seizure medications (ASMs), lacosamide and perampanel, in adult patients with focal epilepsy, compared with lamotrigine and levetiracetam.
Siming Chen, Toshiki Fukasawa, Akio Ikeda, Masato Takeuchi, Akihiro Shimotake, Satomi Yoshida, Koji Kawakami   +6 more
doaj   +1 more source

Interactions Between Lamotrigine and Contraceptives – Communication Practises

BJPsych Open
Aims This audit assesses communication practices regarding interactions between lamotrigine and oral contraceptives in North West Sussex (NWS) Specialist Perinatal Mental Health Services (SPMHS). The predicted outcome includes increasing awareness about
Samina Monir, Cissy Atwine, Helen Hutchings, Michael Harris   +3 more
doaj   +1 more source

Lamotrigine‐induced neutropenia after high‐dose concomitant initiation with phenytoin

Clinical Case Reports, 2021
Lamotrigine has been repeatedly reported to cause hematologic toxicities, which may be associated with high initial doses or excessive escalation. A 29‐year‐old lady experienced profound neutropenia after two weeks of lamotrigine high initial dose ...
Muhammad Salem, Ahmed El‐Bardissy
doaj   +1 more source

Solubility of lamotrigine in age-specific biorelevant media that simulated the fasted- and fed-conditions of the gastric and intestinal environments in pediatrics and adults: implications for traditional, re-formulated, modified, and new oral formulations

BMC Biotechnology, 2023
Background Lamotrigine is an effective antiseizure medication that can be used in the management of focal and generalized epilepsies in pediatric patients.
Ramzi Shawahna, Hala Saba’aneh, Amal Daraghmeh, Yara Qassarwi, Valentina Franco, Xavier Declèves   +5 more
doaj   +1 more source

Evaluating a virtual paediatric adverse drug reaction clinic

British Journal of Clinical Pharmacology, EarlyView.
Aims Adverse drug reactions (ADRs) are a common problem in paediatric health care. There is limited access to expertise in the evaluation and management of potential ADRs in children, limiting access to these services and creating delays in assessment and management.
Emily Hauck, Blanca Del Pozzo‐Magana, Michael Rieder   +2 more
wiley   +1 more source

Fosphenytoin may be effective in shortening the half-life of lamotrigine in case of overdose: a case report

Journal of Medical Case Reports
Background This case study highlights the efficacy of fosphenytoin in managing cardiac arrest and seizures caused by lamotrigine overdose. While activated charcoal and sodium bicarbonate are typically recommended for lamotrigine overdose, alternative ...
Jun Sato, Shingo Ihara, Tsukasa Kuwana, Masao Sekimoto, Yuto Suzuki, Katsuhiro Nakagawa, Nobutaka Chiba, Takeshi Saito, Kosaku Kinoshita   +8 more
doaj   +1 more source

Understanding the behavior of a potential anticancer lamotrigine in explicit solvent (water and DMSO) using quantum mechanical tools and abinitio molecular dynamics

Chemical Physics Impact
Lamotrigine is a medication used to treat epilepsy and help stabilize mood in individuals with bipolar disorder. Epilepsy includes different types of seizures, such as focal seizures, tonic-clonic seizures, and Lennox-Gastaut syndrome, and Lamotrigine is
Elham S. Aazam, Renjith Thomas
doaj   +1 more source

Evaluation of immunomodulatory effects of lamotrigine in BALB/c mice

Acta Pharmaceutica, 2017
Modulation of the immune system has recently been shown to be involved in the pharmacological effects of old antiepileptic drugs and in the pathogenesis of epilepsy.
Abu-Rish Eman Y., Elhayek Shada Y., Mohamed Yehia S., Hamad Islam, Bustanji Yasser   +4 more
doaj   +1 more source

Lamotrigine-induced sexual dysfunction and non-adherence: case analysis with literature review

BJPsych Open, 2017
Background Optimal anti-epileptic drug (AED) treatment maximises therapeutic response and minimises adverse effects (AEs). Key to therapeutic AED
Kenneth R. Kaufman, Melissa Coluccio, Kartik Sivaraaman, Miriam Campeas   +3 more
doaj   +1 more source

Electrocardiographic Evaluation in Patients Receiving Lamotrigine Monotherapy/Duotherapy

Archives of Epilepsy, 2023
Objective:Despite its widespread use and safety data, the cardiac safety of lamotrigine was brought into question in October 2020 when the U.S. Food and Drug Administration issued a safety warning about its cardiac side effects.
Merve Hazal Ser, Bengi Gül Türk, Özgür Selim Ser, Seher Naz Yeni   +3 more
doaj   +1 more source