Results 31 to 40 of about 24,362 (263)
"A COMPARATIVE TRIAL OF LAMOTRIGINE AND CARBAMAZEPINE IN PATIENTS WITH PRIMARY GENERALIZED TONIC CLONIC SEIZURES" [PDF]
Acta Medica Iranica, 2004 Lamotrigine has been used widely in the treatment of partial and secondary generalized seizures. In this study use of lamotrigine as monotherapy for the newly diagnosed primary generalized tonic–clonic seizure has been investigated and compared with ...
H. Ghelichnia +1 more
doaj +2 more sources
Lamotrigine Extraction and Quantification by UPLC-DAD in Plasma from Patients with Bipolar Disorder
International Journal of Analytical Chemistry, 2022 A sensitive and efficient analytical process for detecting lamotrigine in acidic solution based in ultra-high-performance liquid chromatography-diode array detector (UPLC-DAD) was developed; the stationary phase used was a C8, 150 × 4.6 mm, 2.6 µm.
Claudia V. Palacios-Magaña +5 more
doaj +1 more source
Toxicology Reports, 2021 Lamotrigine and levetiracetam are widely used second-generation anti-epileptic drugs. Existing literature indicates that overdose of either drug is typically benign, but neurologic and cardiac toxicity can occur in some cases. In this retrospective study,
Kelly E. Wood +2 more
doaj +1 more source
A Terbium Metal–Organic Framework Platform for Determination of Lamotrigine in Exhaled Breath Condensate [PDF]
Pharmaceutical Sciences, 2022 Background: Lamotrigine is widely used in the management of partial epilepsy, generalized tonic-clonic epilepsy and Lenox-Gastut syndrome and is an add-on therapy in the treatment of complex and simple partial seizures and secondarily generalized tonic ...
Parisa Eydi +4 more
doaj +1 more source
Canadian Journal of Neurological Sciences / Journal Canadien des Sciences Neurologiques, 1996 ABSTRACT:Lamotrigine (LTG) inhibits repetitive high frequency firing in depolarised neurones by selectively prolonging slow inactivation of the sodium channel, thereby suppressing the release of excitatory amino acids. It has been shown to be effective in 11 pivotal double-blind add-on trials in patients with refractory partial seizures with or without
openaire +2 more sources
Differential treatment of bipolar disorder with old and new antiepileptic drugs [PDF]
, 1998 Although lithium remains the preferred medication for bipolar disorders, new investigations suggest that only 60 to 80% of patients have a good response with a classical presentation.
Normann, C. +7 more
core +1 more source
Discovery of a small molecule that inhibits bacterial ribosome biogenesis
eLife, 2014 While small molecule inhibitors of the bacterial ribosome have been instrumental in understanding protein translation, no such probes exist to study ribosome biogenesis.
Jonathan M Stokes +4 more
doaj +1 more source
Pharmaceuticals, 2022 Lamotrigine is widely prescribed to treat bipolar neurological disorder and epilepsy. It exerts its antiepileptic action by blocking voltage-gated sodium channels in neurons.
Juan Antonio Contreras Vite +4 more
doaj +1 more source
Pharmaceuticals, 2023 Intravenous (IV) ketamine and FDA-approved intranasal (IN) esketamine are increasingly used for treatment-resistant depression (TRD). Preliminary studies have suggested a synergistic effect of ketamine and lamotrigine, although the data are inconclusive.
Boney Joseph +13 more
doaj +1 more source
STEVEN JOHNSONS SYNDROM ON LAMOTRIGINE
, 2022 Introduction: Lamotrigine is an anti-epileptic drug indicated for the treatment of bipolar disorder and recurrent depressive disorders. Its efficacy has been demonstrated.
Imane Belabbes and Hassan Kisra
core +1 more source