Results 71 to 80 of about 2,709,539 (294)

Biodegradable ion-exchange microspheres based on modified polylysines [PDF]

, 1995
Poly-L-lysine was synthesized via a triethylamine initiated ring-opening polymerization of Z-L-lysine-N'~-carboxyanhydride,\ud followed by deprotection of the E-amino group. Subsequently the polylysine was sulfamated using a pyridinium-sulfate complex to
Cremers, H.F.M., Feijen, J., Lens, J.P., Seymour, L.   +3 more
core   +4 more sources

Applicability of mitotic figure counting by deep learning: a development and pan‐cancer validation study

FEBS Open Bio, EarlyView.
In this study, we developed a deep learning method for mitotic figure counting in H&E‐stained whole‐slide images and evaluated its prognostic impact in 13 external validation cohorts from seven different cancer types. Patients with more mitotic figures per mm2 had significantly worse patient outcome in all the studied cancer types except colorectal ...
Joakim Kalsnes, Maria X. Isaksen, Frida Julbø, Manohar Pradhan, Andreas Kleppe, Sepp De Raedt, Ole‐Johan Skrede, Turid Torheim, John Arne Nesheim, Hans Martin Mohn, Hanne A. Askautrud, Karolina Cyll, Wanja Kildal, Emma Rewcastle, Melinda Lillesand, Vebjørn Kvikstad, Emiel Janssen, Robert Jones, Odd Terje Brustugun, Bjørn Brennhovd, Erik Skaaheim Haug, Lill‐Tove Rasmussen Busund, Elin Richardsen, Sigve Andersen, Tom Dønnem, Kristina Lindemann, Gunnar Kristensen, Neil A. Shepherd, Marco Novelli, Knut Liestøl, David Kerr, Håvard E. Danielsen, Tarjei S. Hveem   +32 more
wiley   +1 more source

The Effect of Environment on Shear in Strong Gravitational Lenses [PDF]

, 2010
Using new photometric and spectroscopic data in the fields of nine strong gravitational lenses that lie in galaxy groups, we analyze the effects of both the local group environment and line-of-sight galaxies on the lens potential.
Ann I. Zabludoff, Auger, Auger, Bartelmann, Bernardi, Bernardi, Blanton, Bolton, Bower, Brainerd, Charles R. Keeton, Chartas, Chen, Chiba, Congdon, Dai, Dalal, Dalal, Eke, Eke, Fadely, Fassnacht, Fassnacht, Fassnacht, Fassnacht, Fassnacht, Faure, Faure, Fischer, Gavazzi, Gonzalez, Holder, Impey, Ivelina G. Momcheva, Jaunsen, Keeton, Keeton, Keeton, Keeton, Keeton, Keeton, Keeton, Kenneth C. Wong, Kochanek, Kochanek, Koopmans, Koopmans, Koranyi, Kurtis A. Williams, Langston, Lehar, Limousin, Lubin, McIntosh, Metcalf, Momcheva, Morgan, Morgan, Morgan, Moustakas, Ofek, Oguri, Patnaik, Petters, Refsdal, Robertson, Rusin, Rusin, Saha, Saha, Schneider, Suyu, Tonry, Tonry, Treu, Tully, Warren, Wechsler, Williams, Wisotzki, Wright, Zabludoff   +81 more
core   +2 more sources

Why human connection is the true metric of research success

FEBS Open Bio, EarlyView.
Human‐centred mentorship can be shaped by mentor attributes, actions, intrinsic drive and career ambition. Drawing on reflections across Singapore and France, as well as workshop insights from FEBS‐IUBMB ENABLE 2024, this article shows that human‐centred mentorship creates the conditions for sustainable growth, well‐being and retention in research ...
Timothy Lin Yun Tan, Mattias Wei Ren Kon, Xavier Coumoul, Fun Man Fung   +3 more
wiley   +1 more source

Natural Products as Geroprotective Modulators in Diabetic Nephropathy: A Mechanistic Framework Integrating Aging Hallmarks and the AMPK–SIRT1–Nrf2 Axis

Aging and Cancer, EarlyView.
Natural products target the aging kidney in diabetic nephropathy by restoring the AMPK–SIRT1–Nrf2 axis, reducing oxidative stress, inflammation, fibrosis, and cellular senescence while enhancing mitochondrial biogenesis and antioxidant defenses.
Sherif Hamidu, Latif Adams, Eunice Ampem‐Danso, Justice Kumi, Abigail Aning, Fatima Hamidu, Mustapha Abdul Mumin Mohammed, Ayuba Nii Darku Ankrah, Seth Kwabena Amponsah   +8 more
wiley   +1 more source

PKS 1830-211: A Face-On Spiral Galaxy Lens [PDF]

, 2002
We present new Hubble Space Telescope images of the gravitational lens PKS 1830-211, which allow us to characterize the lens galaxy and update the determination of the Hubble constant from this system.
Brian A. McLeod, Christopher D. Impey, Christopher S. Kochanek, Djorgovski S., Emilio E. Falco, Guirado J. C., Hans‐Walter Rix, Joshua N. Winn, Pramesh Rao A., Refsdal S., Subrahmanyan R., Tully R. B.   +11 more
core   +2 more sources

International survey of orthokeratology contact lens fitting.

Contact lens & anterior eye : the journal of the British Contact Lens Association, 2019
PURPOSE . To determine the extent of orthokeratology (OK) contact lens fitting worldwide and to characterize associated demographics and fitting patterns. METHODS .
P. Morgan, N. Efron, C. Woods, J. Santodomingo-Rubido   +3 more
semanticscholar   +1 more source

The Role of Calcitonin Gene‐Related Peptide in High‐Altitude Headache: A Prospective Field Study

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective High‐altitude headache (HAH) is a common neurological condition associated with rapid ascent to high altitude. The pathophysiological mechanisms underlying HAH remain incompletely understood. Calcitonin gene‐related peptide (CGRP), a neuropeptide implicated in migraine pathophysiology, may play a key role in the pathophysiology of ...
Roman Schniepp, Ludwig Karrasch, Helena Breitenstein, Andreas Straube, Katharina Kamm   +4 more
wiley   +1 more source

Cyclodextrins as Emerging Therapeutic Tools in the Treatment of Cholesterol-Associated Vascular and Neurodegenerative Diseases

Molecules, 2016
Cardiovascular diseases, like atherosclerosis, and neurodegenerative diseases affecting the central nervous system (CNS) are closely linked to alterations of cholesterol metabolism. Therefore, innovative pharmacological approaches aiming at counteracting
Caroline Coisne, Sébastien Tilloy, Eric Monflier, Daniel Wils, Laurence Fenart, Fabien Gosselet   +5 more
doaj   +1 more source

CAR T‐Cell Therapy in Neurology: A Scoping Review of Neuro‐Oncology, Autoimmune Diseases & Neurotoxicity

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Chimeric antigen receptor (CAR) T‐cell therapy has been investigated in neurological diseases, encompassing both central nervous system malignancies and autoimmune disorders, thereby extending its application beyond hematological cancers.
Omar Alqaisi, Mohammed Dibas, Patricia Tai, Ala Dibas, Osama Souied, Suhair Al‐Ghabeesh   +5 more
wiley   +1 more source