Assessment of the Adjuvant Effects of Lentinan on the Tuberculosis Subunit Vaccine BG [PDF]
VaccinesObjectives: This study aims to assess the adjuvant effects of lentinan and its combination with Mn(J), a manganese-based colloidal adjuvant, on the BG (fusion protein BfrB-GrpE of Mycobacterium tuberculosis) subunit vaccine.
Shuai Zhou +6 more
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Lentinan inhibits colorectal cancer stemness by binding CD133 and suppressing the CD133/p85/p-AKT signaling axis [PDF]
Frontiers in PharmacologyBackgroundColorectal cancer (CRC) ranks third in the global cancer incidence rate worldwide. Cancer stem cells (CSCs) are key drivers of CRC recurrence, metastasis, and therapy resistance, while therapies against them remain limited.
Yan Liu +16 more
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Prognostic model for gastric cancer patients with COVID-19 and network pharmacology study on treatment by lentinan [PDF]
Scientific ReportsPatients with gastric cancer (GC) are more susceptible to coronavirus disease 2019 (COVID-19), which further worsens their already challenging prognosis. However, there are no effective treatment options for these patients. Lentinan is a potent bioactive
Sitong Zhou, Hao Sun
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Lentinan Reduces Transmission Efficiency of COVID-19 by Changing Aerodynamic Characteristic of Exhaled SARS-CoV-2 Aerosols in Golden Hamsters [PDF]
MicroorganismsLentinan (LNT) was found to reduce the aerosol transmission rate between golden hamsters from 100% (9/9) to 44.4% (4/9). The viral loads in the respiratory system, including the nasal turbinate, trachea, and lung, were significantly reduced in the ...
Cheng Zhang +9 more
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Lentinan enhances CAR-T cell potency in solid tumors by optimizing T cell differentiation [PDF]
Frontiers in ImmunologyCAR-T cell therapy has demonstrated remarkable success in treating hematologic malignancies; however, its efficacy in solid tumors remains constrained.
Xiangyun Niu +11 more
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Supplementation with Lentinan Improves the Colostrum Quality of Holstein Dairy Cows and the Immunity and Antioxidant Capacity of Newborn Calves [PDF]
AnimalsThe aim of this study was to evaluate the effects of lentinan (LNT) on the quality of colostrum produced by perinatal dairy cows and the health status of their newborn calves. A total of 40 expectant Holstein cows, matched for parity and expected date of
Yinghao Huang +8 more
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Fermentation, 2023 Lentinan has important applications in the food and medicine fields. Fermenting Lentinula edodes with Bacillus subtilis natto increased the lentinan extraction yield by 87.13% and greatly altered the molecular structure and antioxidant activity of ...
Mengyue Xu +6 more
doaj +1 more source
Ecotoxicology and Environmental Safety, 2023 Fluopyram, a SDH inhibitor fungicide, is widely used in agriculture to control fungi and nematodes. However, fluopyram has been proved toxic that caused damage to organs through oxidative stress.
Huimin Liu +7 more
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Parasites & Vectors, 2023 Background Toxoplasma gondii (T. gondii) is increasingly considered a risk factor for neurodegenerative diseases. However, there is only limited information on the development of drugs for T. gondii infection.
Shuxi Liu +12 more
doaj +1 more source
Intestinal anti-inflammatory activity of lentinan: influence on IL-8 and TNFR1 expression in intestinal epithelial cells. [PDF]
PLoS ONE, 2013 Inflammatory bowel disease (IBD) is characterized by chronic inflammation of the gastrointestinal tract. It is unknown whether β-1,3;1,6-glucan can induce immune suppressive effects.
Yosuke Nishitani +6 more
doaj +1 more source