Results 181 to 190 of about 3,530 (206)

Lentinan ameliorates burn sepsis by attenuating CD4 + CD25 + Tregs

Burns, 2016
The aim of our study was to investigate the effect of lentinan on regulatory T cells (Tregs) in sepsis, especially on the generation of interleukin (IL)-10 via regulation of Erk-FoxO1 signaling.BalB/c mice were randomized into five groups: sham group, the group with burns plus Pseudomonas aeruginosa infection, and the groups with burns plus P ...
Shou-Xing, Wang, Qing-Yang, Liu, Yong, Li   +2 more
openaire   +2 more sources

Immunopotentiation by the Antitumor Polysaccharide Lentinan

1985
Despite the enormous efforts of researchers around the world, promising cancer chemotherapeutics do not as yet exist, excluding some agents acting against certain cancer types with special characteristics and against certain leukemias. Chemotherapeutic agents possessing direct cytocidal activities on target cancer cells intend to kill the total mass of
Junji Hamuro, Goro Chihara
openaire   +1 more source

[The immunomodulatory effect of lentinan].

Yao xue xue bao = Acta pharmaceutica Sinica, 1996
Lentinan (LTN) was extracted from Lentinus edodes (Berk) Sing with molecular weight of 5 x 10(5). The effects of lentinan on cellular immune function were studied in vivo by measuring the cellular delayed type hypersensitivity (DTH) to dinitrofluorobenzene (DNFB) in cyclophosphamide (Cy)-comprised mice.
G L, Wang, Z B, Lin
openaire   +1 more source

Chronic intravenous administration of lentinan to the rhesus monkey

Toxicology Letters, 1981
The prolonged effects of overdosage with lentinan in the rhesus monkey are associated with foam cell reactions in lung, liver, kidney, spleen, lymph nodes and bone marrow and with varying degrees of vasculitis and associated reactions. A dose level of 0.5 mg/kg/day was without adverse effect.
R J, Sortwell, S, Dawe, D G, Allen, A E, Street, R, Heywood, N A, Edmondson, C, Gopinath   +6 more
openaire   +2 more sources

Lentinan, a New Immuno-accelerator of Cell-mediated Responses

Nature, 1971
BCG is almost the only agent now used as the immuno-accelerator of cell-mediated responses1'3, but it has various biological side effects and a complicated chemical structure, so that it is not necessarily the most suitable agent. We reported that lentinan4,5 and pachymaran6 strongly inhibited the growth of transplanted tumours in mice, and these two ...
Maeda, Y Y, Chihara, G
openaire   +2 more sources

The intravenous toxicity of lentinan to the beagle dog

Toxicology Letters, 1981
The i.v administration of lentinan to the Beagle dog induced changes in the cytoplasm of macrophagic cells in the liver, spleen, kidney, lungs, lymph nodes, small intestine. Electron-lucent or filamentous inclusions were demonstrated in the liver, kidney and spleen. A dose level of 0.5 mg/kg/day was without adverse effect.
H, Chesterman, R, Heywood, T R, Allen, A E, Street, N A, Edmondson, D E, Prentice   +5 more
openaire   +2 more sources

Preclinical Evaluation of Lentinan in Animal Models

1983
Lentinan exerts prominent antitumor effects in allogeneic, syngeneic and autochthonous hosts and prevents chemical and viral carcinogenesis, and increases host-resistance to bacterial, viral and parasitic infections. Lentinan augments helper T cell mediated cytotoxic T cell activity, NK cell activity and humoral immune responses, and activates ...
openaire   +2 more sources

Effect of lentinan on macrophage cytotoxicity against metastatic tumor cells

Cancer Immunology Immunotherapy, 1993
We studied the effect of lentinan, a fungal polysaccharide immunomodulator, on mouse peritoneal macrophages. The i.p. treatment of mice with 10 mg/kg lentinan affected the number, plastic-adherence, and endogen peroxidase activity of peritoneal cells. The cytotoxicity of lentinan-stimulated peritoneal macrophages was determined against several murine ...
A, Ladányi, J, Tímár, K, Lapis
openaire   +2 more sources

Lentinan Dermatitis: Time to Rename Shiitake Dermatitis

Dermatitis, 2021
Estefanía, Cruzval-O'Reilly, Dean S, Morrell, Aída, Lugo-Somolinos   +2 more
openaire   +2 more sources

[Randomized study of lentinan on patients with advanced gastric and colorectal cancer. Tohoku Lentinan Study Group].

Gan to kagaku ryoho. Cancer & chemotherapy, 1986
A randomized study of mitomycin C (MMC)+5-FU [control group] vs MMC+5-FU+lentinan (LNT) [LNT group] was conducted in order to evaluate the effect of LNT against advanced gastric and colorectal cancers by the envelope method in 166 patients, comprising of 115 cases of gastric cancer and 51 cases of colorectal cancer.
A, Wakui, M, Kasai, K, Konno, R, Abe, R, Kanamaru, K, Takahashi, Y, Nakai, Y, Yoshida, H, Koie, H, Masuda   +9 more
openaire   +1 more source