Results 161 to 170 of about 2,093 (209)

Clinical Efficacy of Lentinan on Neoplastic Diseases

1983
Lentinan, a β-(1-3)-glucan with some β-(1-6)-gluco-pyranoside branchings, has been extracted and purified from Lentinus edodes a most popular edible mushroom in Japan. This substance has been shown to act as an immunostimulating agent through host defense mechanisms as reported by Chihara et al (1, 2).
T, Taguchi, H, Furue, T, Kimura, T, Kondo, T, Hattori, N, Ogawa   +5 more
openaire   +2 more sources

Antitumor and immunological activity of lentinan in comparison with LPS

International Journal of Immunopharmacology, 1994
Lentinan manifests marked antitumor and antimetastatic activity in numerous tumor/host systems, and prevents chemical and viral carcinogenesis. Modulation of immune or vascular functions by lentinan is involved in its antitumor effects. The impact of lentinan on the functions of macrophages is distinct from that of LPS.
M, Suzuki, F, Takatsuki, Y Y, Maeda, J, Hamuro, G, Chihara   +4 more
openaire   +2 more sources

Chronic intravenous administration of lentinan to the rhesus monkey

Toxicology Letters, 1981
The prolonged effects of overdosage with lentinan in the rhesus monkey are associated with foam cell reactions in lung, liver, kidney, spleen, lymph nodes and bone marrow and with varying degrees of vasculitis and associated reactions. A dose level of 0.5 mg/kg/day was without adverse effect.
R J, Sortwell, S, Dawe, D G, Allen, A E, Street, R, Heywood, N A, Edmondson, C, Gopinath   +6 more
openaire   +2 more sources

[The immunomodulatory effect of lentinan].

Yao xue xue bao = Acta pharmaceutica Sinica, 1996
Lentinan (LTN) was extracted from Lentinus edodes (Berk) Sing with molecular weight of 5 x 10(5). The effects of lentinan on cellular immune function were studied in vivo by measuring the cellular delayed type hypersensitivity (DTH) to dinitrofluorobenzene (DNFB) in cyclophosphamide (Cy)-comprised mice.
G L, Wang, Z B, Lin
openaire   +1 more source

Immunopotentiation by the Antitumor Polysaccharide Lentinan

1985
Despite the enormous efforts of researchers around the world, promising cancer chemotherapeutics do not as yet exist, excluding some agents acting against certain cancer types with special characteristics and against certain leukemias. Chemotherapeutic agents possessing direct cytocidal activities on target cancer cells intend to kill the total mass of
Junji Hamuro, Goro Chihara
openaire   +1 more source

Lentinan and other antitumoral polysaccharides

1999
Despite a great deal of effort made by many researchers throughout the world, chemotherapeutic agents that attack cancer cells directly do not seem to have the expected effects except on some leukaemias. Besides, these agents show strong toxicity to the host, and reduce the host defense against infections, especially destroying lymphocytes and bone ...
Yukiko Y. Maeda, Goro Chihara
openaire   +1 more source

Preclinical Evaluation of Lentinan in Animal Models

1983
Lentinan exerts prominent antitumor effects in allogeneic, syngeneic and autochthonous hosts and prevents chemical and viral carcinogenesis, and increases host-resistance to bacterial, viral and parasitic infections. Lentinan augments helper T cell mediated cytotoxic T cell activity, NK cell activity and humoral immune responses, and activates ...
openaire   +2 more sources

The effect of lentinan on fertility and general reproductive performance of the rat

Toxicology Letters, 1981
Lentinan, a polysaccharide [(1 leads to 3)-beta-D-glucan], at 0.01, 0.10 or 1.0 mg/kg/day, was administered i.v. once daily to male rats for 9 weeks and to females for 2 weeks before mating. Some animals continued to be treated until they were killed during gestation: others were killed on day 21 post partum.
D D, Cozens, R E, Masters, R, Clark, J M, Offer   +3 more
openaire   +2 more sources

The effect of lentinan on dexamethasone-induced immunosuppression in mice

International Journal of Biological Macromolecules
The immune system acts as a vital defense barrier against pathogenic invasions, and its stable operation is crucial for maintaining body health. Nevertheless, various natural or artificial factors can compromise the body's immune function, leading to immunosuppression, which may interfere with the efficacy of vaccination and increase the susceptibility
Lina, Jiao, Haiyan, Jin, Zuchen, Song, Zheng, Wang, Lin, Yu, Ruihong, Yu, Deyun, Wang, Qian, Gao, Song, Peng, Haifeng, Sun, Tao, Zhang, Xue Fei, Wang, Zhenguang, Liu   +12 more
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[Randomized study of lentinan on patients with advanced gastric and colorectal cancer. Tohoku Lentinan Study Group].

Gan to kagaku ryoho. Cancer & chemotherapy, 1986
A randomized study of mitomycin C (MMC)+5-FU [control group] vs MMC+5-FU+lentinan (LNT) [LNT group] was conducted in order to evaluate the effect of LNT against advanced gastric and colorectal cancers by the envelope method in 166 patients, comprising of 115 cases of gastric cancer and 51 cases of colorectal cancer.
A, Wakui, M, Kasai, K, Konno, R, Abe, R, Kanamaru, K, Takahashi, Y, Nakai, Y, Yoshida, H, Koie, H, Masuda   +9 more
openaire   +1 more source