Results 161 to 170 of about 411,689 (282)

Enhancing the transduction efficiency of lentiviral vectors in CAR-T cell therapy through an optimization workflow. [PDF]

Front Med (Lausanne)
Ferreira R, Gama JFG, Godinho-Santos A, Goncalves J.   +3 more
europepmc   +1 more source

TP53 Loss Elevates NF‐κB‐IFN‐β‐MHC‐Ia Signaling to Promote NK Cell Resistance in Osteosarcoma

Advanced Science, EarlyView.
TP53 loss in a transforming or osteosarcoma cell promotes cytosolic DNA accumulation, activating NF‐κB‐dependent IFN‐β production. Autocrine IFN‐β signaling increases cell‐surface HLA‐Ia expression, strengthens inhibitory KIR signaling in natural killer cells, and thereby enables the affected cell to evade NK cell‐mediated cytotoxicity.
Guihui Qin, Cheung Kwan Yeung, Ye Yi, Dejin Zheng, Miaoman Ye, Chi‐Chong Chio, Jinjie Wu, Siyi Fu, Chu‐Xia Deng, Ren‐He Xu   +9 more
wiley   +1 more source

Adaptation of lentiviral vectors for viral gene therapy and their impact on host cell biology. [PDF]

J Transl Med
Kaiser CW, Rouchka EC, Smith ML.
europepmc   +1 more source

DDX21 Enhances Radiosensitivity in Head and Neck Squamous Cell Carcinoma by Suppressing MK2‐Mediated DNA Damage Response

Advanced Science, EarlyView.
DDX21 suppresses MK2 activation by directly inhibiting Thr334 phosphorylation in a p38‐independent manner, thereby impairing DNA damage response. Clinically, patients with well‐differentiated tumors exhibiting high DDX21 expression are more likely to benefit from adjuvant radiotherapy, whereas those with low DDX21 levels are predisposed to ...
Tianru Yang, Ting Shen, Yanfang Qiu, Wei Zhang, Ziran Zheng, Jiayi Sun, Yuedi Yao, Mianfeng Yao, Jiang Li   +8 more
wiley   +1 more source

Switchable Retargeting of Lentiviral Vectors Through a VSV-G-Binding Adapter Molecule. [PDF]

Viruses
Zhuchkov VA, Valikhov MP, Kravchenko YE, Frolova EI, Chumakov SP.   +4 more
europepmc   +1 more source

A Metabolic‐Epigenetic Axis of AARS1/IGF2BP3‐K280 Lactylation Sustains Endometrial Cancer Stemness and Recurrence

Advanced Science, EarlyView.
Lactate‐driven endometrial cancer relapse is mediated by enzymatic protein modification. Elevated lactate levels activate AARS1, which catalyzes K280 lactylation of IGF2BP3, therefore stabilizing HMGA2 mRNA and promoting tumor stemness and recurrence.
Peng Jiang, Yunfeng Zheng, Chenfan Tian, Yuan Tu, Xiaoxia Chang, Jiaxin Yu, Hangkun Yu, Chunxia Gong, Jie Xiong, Philip N. Baker, Yong Fu, Chao Tong   +11 more
wiley   +1 more source

The Era of Gene Therapy: The Advancement of Lentiviral Vectors and Their Pseudotyping. [PDF]

Viruses
Jargalsaikhan BE, Muto M, Ema M.
europepmc   +1 more source

Nuclear IDH3A Drives Transcriptional Programs in Melanoma via the YBX1–JUN/FOS Axis

Advanced Science, EarlyView.
Genomic amplification drives aberrant nuclear localization of IDH3A in melanoma. Independent of its canonical metabolic activity, nuclear IDH3A cooperates with YBX1 to activate the c‐JUN/c‐FOS transcriptional program, while NONO facilitates its nuclear localization.
Juan Ran, Yanchun Fang, Shengming Ruan, Juling Wang, Songbai Liu, Yuan Mao, Dongsheng Hou, Yanping Wang, Zi Ye, Qiong Li, Daoxiang Zhang   +10 more
wiley   +1 more source

Transduction of Quiescent Human Hematopoietic Stem and Progenitor Cells Using Lentiviral Vectors and Virus-Like Particles. [PDF]

Curr Protoc
Klatt D, Brendel C.
europepmc   +1 more source

Impact of the Membrane Structure of the Stationary Phase on Steric Exclusion Chromatography (SXC) of Lentiviral Vectors. [PDF]

Membranes (Basel), 2023
Labisch JJ, Wiese GP, Pflanz K, Linkhorst J.   +3 more
europepmc   +1 more source