Results 171 to 180 of about 202,804 (290)

A Hybrid Nanovector of Suicide Gene Engineered Lentivirus Coated with Bioreducible Polyaminoglycosides for Enhancing Therapeutic Efficacy against Glioma [PDF]

, 2019
Wenhua Fan, Meiyu Shao, Junwen Zhang, Guishan Jin, Fusheng Liu, Fu‐Jian Xu   +5 more
openalex   +1 more source

High‐Content SRS Imaging Unveils Altered Cholesterol Metabolism in Ovarian Cancers Under CAR‐T Treatment

Advanced Science, EarlyView.
High‐content Stimulated Raman Scattering (SRS) Imaging reveals that ovarian cancer cells surviving Chimeric Antigen Receptor (CAR) ‐T cell challenge exhibit increased cholesterol esterification. Pharmacological inhibition of this pathway with Avasimibe significantly enhances CAR‐T induced killing of ovarian cancer cells by reducing cancer cell ...
Chinmayee V. Prabhu Dessai, Zhuoying Huang, Haonan Lin, Guangrui Ding, Hongjian He, Menna Siddiqui, Meng Zhang, Wilson Wong, Ji‐Xin Cheng   +8 more
wiley   +1 more source

Bone Marrow Stem Cells Expressing Keratinocyte Growth Factor via an Inducible Lentivirus Protects against Bleomycin-Induced Pulmonary Fibrosis

, 2009
Susana Aguilar, Chris J. Scotton, Katrina McNulty, Emma Nye, Gordon Stamp, Geoff Laurent, Dominique Bonnet, Sam M. Janes   +7 more
openalex   +2 more sources

Engineered Small Extracellular Vesicles Targeting Tumor‐Associated Endothelial Cells to Effectively Remodel the Glioma Microenvironment

Advanced Science, EarlyView.
This study developed a novel drug delivery platform that overcomes the blood‐brain barrier in glioblastoma. By fusing IGFBP7 with small extracellular vesicles, the platform specifically targets tumor vasculature. It effectively delivers temozolomide, suppressing tumor growth at low doses.
Lingling Liu, Feiyang Xu, Zhiming Zheng, Xiaodan Yang, Fang Yang, Pei Liu, Yuankun Chen, Yunshu Yang, Junli Zhao, Peiyan Yang, Xiaojing Zheng, Xiaohong Sun, Ping Mao, Qinwen Mao, Hao Guan, Haibin Xia, Weifeng Zhang, Dan Xiao   +17 more
wiley   +1 more source

MBD3 increased expression by BRD4 and facilitated castration-resistant prostate cancer cell proliferation by inhibiting PTEN. [PDF]

Discov Oncol
Pan L, Shen J, Li Z, Xie G, Chen C, Chen X.   +5 more
europepmc   +1 more source

Toll Like Receptor 9 (TLR9) Polymorphism G520R in Sheep Is Associated with Seropositivity for Small Ruminant Lentivirus

, 2013
Theologia Sarafidou, Costas Stamatis, Georgia Kalozoumi, Vassiliki Spyrou, George C. Fthenakis, Charalambos Billinis, Zissis Mamuris   +6 more
openalex   +2 more sources

Context‐Dependent Role of GDF15: GDF15+ Tumor‐Associated Macrophages Suppress OSCC Progression by Enhancing Phagocytosis

Advanced Science, EarlyView.
This study identifies GDF15+ TAMs as a cell subset mediating tumor regression after immunotherapy. Macrophage‐intrinsic GDF15 enhances phagocytosis and antigen cross‐presentation to CD8+ T cells through the NF‐κB signaling pathway, thereby inhibiting tumor progression.
Xinyu Zhou, Zhihang Zhou, Houyu Ju, Chaoyang Guo, Fangxing Zhu, Yiyi Zhang, Xu Chen, Tongchao Zhao, Laiping Zhong, Jingzhou Hu   +9 more
wiley   +1 more source

Matrix stiffness induces Ca²⁺-DCLK1-PIP5K1A mechanotransduction as a context-specific amplifier in pancreatic cancer progression and chemotherapy resistance. [PDF]

Exp Hematol Oncol
Zhang H, Zhao C, Chen J, Hu X, Bai J, He L, Deng Z, Yin T.   +7 more
europepmc   +1 more source

Retrospective seroepidemiological study of small ruminant lentivirus, paratuberculosis and brucellosis in goats from Mexico, based on multiplex assay

Ana D. Rodríguez-Cortez, Cecilia Montoya‐Carrillo, Héctor Daniel Nájera-Rivera, Alejandro Zaldivar-Gómez, Enrique Herrera Lopez, Oscar Rico‐Chávez, Hugo Ramírez Álvarez, Alejandro De Las Peñas, Efrén Díaz Aparicio, Laura Cobos-Marín   +9 more
openalex   +2 more sources

TGFβ1 Activates Lnc‐APUE to Promote Tumor Metastasis via the Alu Element‐Driven STAU1‐Mediated Decay of CDH1 mRNA

Advanced Science, EarlyView.
We delineate a TGFβ1/SMAD/lnc‐APUE/E‐cadherin axis wherein TGFβ1 signaling activates lnc‐APUE; lnc‐APUE subsequently downregulates E‐cadherin expression via Alu element‐driven STAU1‐mediated decay of CDH1 mRNA, thereby promoting tumor metastasis. Our findings reveal a novel regulatory function for lnc‐APUE within the SMD pathway, elucidate a distinct ...
Song‐Yang Li, Jia‐Hui Huang, Jin‐E Yang, Yi‐Hang Li, Juan‐Zhen Hong, Ting‐Ting Wang, Ying‐Lei Chi, Meng‐Zhi Wu, Wei Wang, Ying Zhu, Shi‐Mei Zhuang   +10 more
wiley   +1 more source