Results 261 to 270 of about 169,744 (339)

m6A‐Modified circRAPGEF1 Interaction with IGF2BP3 Promotes Hepatocellular Carcinoma Progression via Reprogramming Aspartate Metabolism

Advanced Science, EarlyView.
In hepatocellular carcinoma (HCC), the m6A‐modified circRAPGEF1 destabilizes ASS1 mRNA via competitive binding to IGF2BP3, driving aspartate metabolic reprogramming in liver cancer stem cells (LCSCs). This cascade enhances stemness properties and reduces sorafenib sensitivity in LCSCs, thereby identifying circRAPGEF1 as a promising therapeutic target ...
Juanyi Shi, Sintim Mui, Yongcong Yan, Shaomin Liu, Kai Wen, Chuanchao He, Huoming Li, Hao Liao, Meng Tao, Jiahua Wen, Weidong Wang, Xiaoding Xu, Zhenyu Zhou, Zhiyu Xiao   +13 more
wiley   +1 more source

LAMC3 interference reduces drug resistance of carboplatin-resistant ovarian cancer cells. [PDF]

Sci Rep
Liu X, Zhang J, Xia L, Su Y, Chen X, Wang C, Ouyang Y, Yin F.   +7 more
europepmc   +1 more source

USP8‐Governed MDA5 Homeostasis Promotes Innate Immunity and Autoimmunity

Advanced Science, EarlyView.
This study reveals that USP8 stabilizes MDA5 via AKT‐mediated phosphorylation (Ser718), enhancing their interaction and MDA5 deubiquitination. USP8 inactivation degrades MDA5, suppressing type I IFN and cytokine production. Pharmacological inhibition of USP8/AKT alleviates MDA5‐driven autoimmunity, demonstrating the USP8‐MDA5 axis as a therapeutic ...
Qimin Zhang, Shan Huang, Yan He, Weiwei Wang, Chao Tong, Mengru Ma, Manyu Zhao, Lian Yi, Klaus‐Peter Knobeloch, Peijing Zhang   +9 more
wiley   +1 more source

Computational identification of small molecules for increased gene expression by synthetic circuits in mammalian cells. [PDF]

Nat Commun
Pisani M, Calandra F, Rinaldi A, Cella F, Tedeschi F, Boffa I, Vozzi D, Brunetti-Pierri N, Carissimo A, Napolitano F, Siciliano V.   +10 more
europepmc   +1 more source

Pseudotyped Lentivirus Vectors Derived from Simian Immunodeficiency Virus SIVagm with Envelope Glycoproteins from Paramyxovirus

, 2003
Masanori Kobayashi, Akihiro Iida, Yasuji Ueda, Mamoru Hasegawa   +3 more
openalex   +1 more source

STK25 Loss Augments Anti‐PD‐1 Therapy Efficacy by Regulating PD‐L1 Stability in Colorectal Cancer

Advanced Science, EarlyView.
This study demonstrates that STK25 depletion facilitates CRC immune escape through the inhibition of PD‐L1 Ser283 phosphorylation‐mediated ubiquitination, and promotes tumor growth. Furthermore, these findings identify STK25 as a potential therapeutic target to trigger antitumor immunity and promote immunotherapy efficacy. Abstract Tumor immune evasion
Xiaowen Qiao, Pu Xing, Hao Hao, Jiangbo Chen, Lin Song, Yifan Hou, Xinying Yang, Kai Weng, Jie Chen, Pin Gao, Tongkun Song, Hong Yang, Tianqi Liu, Yumeng Ran, Bo Chen, Wei Zhao, Jiabo Di, Zaozao Wang, Jun Zhang, Xiangqian Su, Beihai Jiang   +20 more
wiley   +1 more source

Coactivator Associated Arginine Methyltransferase 1 Modulates Cartilage Degeneration and Chondrocyte Apoptosis in Osteoarthritis by Regulating ERK1/2 Signaling Pathway. [PDF]

Aging Cell
Yuan J, Tian J, Liu R, Qiu X, He D, He G, Zhang T, Li P, Zhao B, Wang Y.   +9 more
europepmc   +1 more source

Capsid-Dependent and -Independent Postentry Restriction of Primate Lentivirus Tropism in Rodent Cells

, 2003
Théodora Hatziioannou, Simone Cowan, Paul D. Bieniasz   +2 more
openalex   +1 more source

Brachyury‐Activated Fucoidan Hydrogel Microspheres Rejuvenate Degenerative Intervertebral Discs Microenvironment

Advanced Science, EarlyView.
This study describes the creation of injectable Brachyury (Bry) mRNA‐loaded Fucoidan‐functionalized GelMA hydrogel microspheres (BLNP@GF). These microspheres efficiently suppress inflammation, enhance extracellular matrix (ECM) synthesis in degenerated nucleus pulposus cells, and mitigate intervertebral disc degeneration (IVDD) in rat models.
Yuhao Gong, Wenxiao Shi, Xingzhu Liu, Hang Yu, Yinghui Wu, Yanzhang Xia, Caichun Yue, Chongkai Yang, Cong Shen, Renjun Pei, Tianwen Xin, Hailong Pei, Jun Shen   +12 more
wiley   +1 more source

Synergistic effects and mechanism of recombinant viral vector-mediated STAT1 overexpression and STAT3 silencing on glioma U251 apoptosis. [PDF]

Mol Biol Rep
Hu XL, Li H, Zhang GD, Lin C, Huang P, Chen XF, Wan F, Dou CW, Ju HT.   +8 more
europepmc   +1 more source