Results 261 to 270 of about 172,662 (343)

Alternative Pathway for Methyl Supply through the Coupling of SHMT1 and PEMT to Maintain Astrocytic Homeostasis in Parkinson's Disease

Advanced Science, EarlyView.
In Parkinson's disease, SHMT1 downregulation disrupts its interaction with PEMT in astrocytes, reducing SAM levels. This leads to H3K4me1 hypomethylation and decreased Slc1a2/Glul expression, ultimately exacerbating neuroexcitotoxicity and dopaminergic neuron loss.
Yue‐Han Chen, Rong‐Xin Zhu, Nuo‐Xi Zhang, Ting‐Ting Sun, Xi‐Wei Zhang, Yu‐Jie Zhao, Ben‐Yu He, Hang Yao, Ren‐Hong Du, Lei Cao, Wen‐Bin Zhang, Wei‐Guo Liu, Yun Cai, Cong Wang, Gang Hu, Yao Wei, Yang Liu, Ming Lu   +17 more
wiley   +1 more source

Threonyl-tRNA synthetase activates STAT3 by a nontranslational mechanism. [PDF]

J Biol Chem
Barai P, Abdullah R, Bendre SV, Weisser E, van der Donk MJ, Wong KL, Reyes-Ordoñez A, Nelson ER, Chen J.   +8 more
europepmc   +1 more source

Efficacy and safety of myocardial gene transfer of adenovirus, adeno-associated virus and lentivirus vectors in the mouse heart

Gene Therapy, 2015
M. Merentie, L. Lottonen-Raikaslehto, V. Parviainen, J. Huusko, S. Pikkarainen, M. Mendel, N. Laham-Karam, V. Kärjä, R. Rissanen, M. Hedman, S. Ylä-Herttuala   +10 more
semanticscholar   +1 more source

Caspase‐3/GSDME‐Mediated Trophoblast Pyroptosis and Reciprocal Macrophage Polarization Contribute to Inflammation in Early‐Onset Preeclampsia

Advanced Science, EarlyView.
In trophoblast cells, T/S (TNFα + SM164) activated caspase‐3, which cleaved GSDME to switch apoptosis to pyroptosis, causing cell swelling, membrane rupture, and release of LDH, HMGB1, IL‐1β and IL‐18. These cytokines induced pro‐inflammatory macrophage polarization, which in turn reinforced pyroptotic signaling in trophoblasts, amplifying systemic ...
Baoying Huang, Weinan Deng, Shilei Bi, Yifan Wang, Zhaowei Tu, Lijun Huang, Lili Du, Lizi Zhang, Zhoushan Feng, Wei Sun, Tengfei Liu, Julia Kzhyshkowska, Haibin Wang, Jingsi Chen, Dunjin Chen, Shuang Zhang   +15 more
wiley   +1 more source

NOLC1 suppresses immunochemotherapy by inhibiting p53-mediated ferroptosis in gastric cancer. [PDF]

Elife
Zhao S, Lin J, Zhu B, Jin Y, Dong Q, Ruan X, Jin D, Yi Y, Bai B, Li H, Liang D, Lu J, Meng L, Wang X, Cui Y, Gu Y, Shen X, Lu X, Rao S, Sun W.   +19 more
europepmc   +1 more source

Increase of C1q biosynthesis in brain microglia and macrophages during lentivirus infection in the rhesus macaque is sensitive to antiretroviral treatment with 6-chloro-2′,3′-dideoxyguanosine

, 2005
Candan Depboylu, Michael Schäfer, Wilhelm Schwaeble, Todd A. Reinhart, Hiroshi Maeda, Hiroaki Mitsuya, Ruslan Damadzic, Dianne M. Rausch, Lee E. Eiden, Eberhard Weihe   +9 more
openalex   +2 more sources

Down-regulating HIF-1α by lentivirus-mediated shRNA for therapy of triple negative breast cancer

Cancer Biology & Therapy, 2015
Shuang Li, Qingzhu Wei, Qin Li, Bin Zhang, Qiang Xiao   +4 more
semanticscholar   +1 more source

Alphaviral Capsid Proteins Inhibit Stress Granule Assembly via Competitive RNA Binding With G3BP1

Advanced Science, EarlyView.
Stress granules exert antiviral functions. This study illustrates a conserved function of alphaviral capsid proteins in modulating stress granules. Oligomerization mediated by a helical motif coupled with a positively charged intrinsically disordered region (IDR) directly competes with G3BP1 for RNA binding, thereby disrupting G3BP1‐RNA liquid–liquid ...
Yun Zhang, Yi Liu, Zhiying Yao, Haolong Lai, Xiaoxin Chen, Ziqiu Wang, Yiqiong Bao, Tingting Li, Xiaoming Zhou, Xiabin Chen, Peiguo Yang   +10 more
wiley   +1 more source

ALAS2 Prevents Neonatal Necrotizing Enterocolitis by Improving Ferroptosis in Intestinal Epithelial Cells Through Inhibition of Oxidative Stress. [PDF]

Mediators Inflamm
Hao Z, Han J, Yao T, Zhao Z, Fan W, Jiang Z, Wang Y, Yang X, Xu Z.   +8 more
europepmc   +1 more source