Results 271 to 280 of about 172,662 (343)

Liposome-lentivirus hybrid carriers for miRNA therapy of liver cancer stem cells with molecular mechanism study on tumor progression hamper effects [PDF]

Sun Fen, Huaqing Chen, Xiaoyong Dai, Yibo Hou, Jing Li, Yinghe Zhang, Laiqiang Huang, Bing Guo, Dongye Yang   +8 more
openalex   +1 more source

Depletion of the RNA‐Editing Enzyme ADAR1 Invigorates the Antitumor Immunity of NK Cells

Advanced Science, EarlyView.
ADAR1 is upregulated in NK cells from melanoma patients, impairing their function. Its loss enhances NK cell tumor infiltration and cytotoxicity in vitro and in vivo. Mechanistically, ADAR1 deficiency destabilizes CD38 mRNA to reduce its expression, thereby increasing NK cell mobility and killing, which nominates it as a therapeutic target for NK cell ...
Shuhan Chen, Di Lu, Rukang Liang, Weikeng Tan, Erming Zhao, Sihuang Wu, Xintong Li, Yulong Song, Miaojian Wan, Xiaoyuan Xie, Qi Zhang, Qiuli Liu   +11 more
wiley   +1 more source

ATF4 promotes renal tubulointerstitial fibrosis through hexokinase II-mediated glycolysis. [PDF]

Front Immunol
Feng S, Gao Y, Wang Z, Ni W, Zhou Y, Yuan M, Ge J, Sun L, Liu B, Qian H, Li Z.   +10 more
europepmc   +1 more source

Gabpα‐Pparγ Complex Determines Glycolytic Capacity and Lactic Acid Homeostasis in Brown Fat

Advanced Science, EarlyView.
This study identifies the Gabpα–Pparγ complex as a key transcriptional regulator that couples glycolysis to lactate‐driven thermogenesis in brown adipose tissue by directly activating Eno1 transcription. ‌Competitive disruption of this interaction impairs lactate metabolism and thermogenic capacity.
Zhihan Wang, Huanyu Wang, Qianqian Kang, Ruping Pan, Rui He, Min Yang, Jiadai Liu, Xuemin Peng, Yuyu Xie, Hongyan Deng, Wenshe Wang, Zengzhe Zhu, Jing Ge, Yulian Liu, Ronghui Gao, Yaming Guo, Peng Yu, Limeng Pan, Danpei Li, Pema Maretich, Xiaoping Luo, Xuefeng Yu, Yong Chen   +22 more
wiley   +1 more source

The role and mechanism of transcription factor KLF4 in regulating mitochondrial damage and apoptosis by activating chondrocyte autophagy in osteoarthritis. [PDF]

Sci Rep
Feng W, Wang H, Zhang G, Gao W, Li H, Liu H, Sun Y.   +6 more
europepmc   +1 more source

Establishment of an immortalized cell line derived from the prairie vole via lentivirus-mediated transduction of mutant cyclin-dependent kinase 4, cyclin D, and telomerase reverse transcriptase

, 2015
Masafumi Katayama, Tohru Kiyono, Kengo Horie, Takashi Hirayama, Takahiro Eitsuka, Kengo Kuroda, Kenichiro Donai, Shizu Hidema, Katsuhiko Nishimori, Tomokazu Fukuda   +9 more
openalex   +1 more source

Genome‐Wide CRISPR Screen Reveals PIK3CA Inhibition Enhances Lipid Nanoparticle‐Mediated siRNA Delivery

Advanced Science, EarlyView.
A genome‐wide CRISPR screen and identifies PIK3CA as a key regulator of lipid nanoparticle (LNP) uptake is performed. Modulating PIK3CA with small‐molecule inhibitor BAY1082439 enhanced LNP uptake, siRNA delivery, and gene silencing in a variety of epithelial cells, and improved therapeutic outcomes in vivo.
Wenhan Wang, Kangfu Chen, Zongjie Wang
wiley   +1 more source

Pbk positively regulates myoblast differentiation and muscle regeneration via enhancing AMPK/ULK1 mediated myogenic autophagy. [PDF]

J Transl Med
Wang D, Shan D, Zhao D, Dai T, Liu F, Yan C.   +5 more
europepmc   +1 more source

Lentivirus-Mediated BCL-XL Overexpression Inhibits Stem Cell Apoptosis during Ex Vivo Expansion and Provides Competitive Advantage Following Xenotransplantation [PDF]

Patricia M. A. Zehnle, Ying Wu, Naile Koleci, Sheila Bohler, Miriam Erlacher   +4 more
openalex   +1 more source

Feline Lentivirus Group [PDF]

, 2020
openaire   +1 more source