Engineered RNA Devices for In Vivo Targeted Therapeutics via Advanced Delivery Systems
Aggregate, Volume 6, Issue 11, November 2025.Schematic illustration of engineered RNA devices for in vivo targeted therapeutics via advanced delivery systems. ABSTRACT Engineered RNA devices can identify disease‐specific markers and precisely regulate gene expression, which is of great significance to the development of precision medicine.
Wei Luo +6 more
wiley +1 more source
Relations of environmental contaminants, algal toxins, and diet with the reproductive success of American alligators on Florida Lakes [PDF]
, 2001 (113 page ...
Arnold, Beverly S. +3 more
core
Progastrin Promotes Colorectal Cancer Stem Cell‐Like Properties via the Receptor PZR
Advanced Science, Volume 12, Issue 38, October 13, 2025.The tumor microenvironment supports colorectal cancer (CRC) progression by maintaining cancer stem cells (CSCs) through progastrin (PG). This study identifies Protein Zero‐Related protein (PZR) as an essential receptor for PG activity, promoting CSC‐like signaling via SHP2/SRC/β‐catenin.
Julie Nguyen +22 more
wiley +1 more source
Muerte súbita en paciente con síndrome LEOPARD / Sudden death in patients with LEOPARD syndrome
CorSalud, 2015 LEOPARD or Moynahan syndrome, also called multiple lentigines, is a rare genetic disease which causes multiple visceral abnormalities, including heart abnormalities, and may trigger sudden death.
Eliany Rodríguez Moreno +6 more
doaj
Síndrome de Noonan: actualización genética, clínica y de opciones terapéuticas
Anales de Pediatría, 2020 Resumen: El síndrome de Noonan (SN) es una enfermedad de origen genético relativamente frecuente cuyas manifestaciones fundamentales son la talla baja, la cardiopatía congénita y un fenotipo facial característico.La causa del síndrome de Noonan y de ...
Atilano Carcavilla +9 more
doaj +1 more source
The culture of JACMP, the sanctity of editorial independence, and why your ego is not your amigo
Journal of Applied Clinical Medical Physics, Volume 26, Issue 12, December 2025.
Michael D. Mills
wiley +1 more source
Pathogenesis of multiple lentigines in LEOPARD syndrome with PTPN11 gene mutation.
Acta Dermato-Venereologica, 2015 LEOPARD syndrome (LS) is an autosomal dominant condition with multiple anomalies, including multiple lentigines. LS is caused by mutations in PTPN11, encoding the protein tyrosine phosphatase, SHP-2.
S. Motegi +8 more
semanticscholar +1 more source
PTPN11 Mutations in LEOPARD Syndrome: Report of Four Cases in Taiwan
Journal of the Formosan Medical Association, 2009 LEOPARD syndrome (LS) is a rare, autosomal dominant disorder. The typical clinical presentation includes multiple lentigines and cardiac defects. Mutation analysis of the PTPN11 gene is feasible.
I-Shou Lin +4 more
doaj +1 more source
Young at Heart: Pioneering Approaches to Model Nonischaemic Cardiomyopathy with Induced Pluripotent Stem Cells [PDF]
, 2016 A mere 9 years have passed since the revolutionary report describing the derivation of induced pluripotent stem cells from human fibroblasts and the first in-patient translational use of cells obtained from these stem cells has already been achieved ...
Gowran, Aoife +7 more
core +4 more sources
Syndrome de Leopard, distúrbio da crista neural: relato de um caso
Arquivos de Neuro-Psiquiatria, 1981 A síndrome de Leopard é uma condição autosoma dominante de variável expressão fenotípica. Uma minoria apenas dos pacientes apresenta todos os componentes da síndrome, ou seja, lentigenes múltiplas (L), alterações eletrocardiográficos (E), hipertelorismo ...
Marco Aurelio Lana Peixoto +4 more
doaj +1 more source