SHP-2 deletion in postmigratory neural crest cells results in impaired cardiac sympathetic innervation [PDF]
, 2014 Autonomic innervation is an essential component of cardiovascular regulation that is first established from the neural crest (NC) lineage in utero and continues developing postnatally.
Conway, Simon J. +5 more
core +2 more sources
Ecology and Evolution, Volume 16, Issue 1, January 2026.We conducted presence/non‐detection sampling of the Critically Endangered northern white‐cheeked gibbon in Lao PDR. Occupancy was found to be a function of human usage of the site, distance from the nearest road, and the uninterruptedness of forest cover.
Jay White +3 more
wiley +1 more source
Prevalence of myocarditis and its contribution to the course of primary myocardial hypertrophy
Российский кардиологический журнал, 2023 Aim. To assess the incidence of myocarditis in patients with primary myocardial hypertrophy and to study its contribution to the disease course.Material and methods. The study included 100 patients with primary left ventricular myocardial hypertrophy, 52
Yu. A. Lutokhina +6 more
doaj +1 more source
The likely effects of thermal climate change on vertebrate skeletal muscle mechanics with possible consequences for animal movement and behaviour [PDF]
, 2019 Climate change can involve alteration in the local temperature that an animal is exposed to, which in turn may affect skeletal muscle temperature.
Abrahams +100 more
core +1 more source
Phosphatase-independent functions of SHP2 and its regulation by small molecule compounds
Journal of Pharmacological Sciences, 2020 SHP2 is a non-receptor protein tyrosine phosphatase encoded by the PTPN11 gene in human. Clinically, SHP2 has been identified as a causal factor of several diseases, such as Noonan syndrome, LEOPARD syndrome as well as myeloid malignancies. Interestingly,
Wenjie Guo, Qiang Xu
doaj +1 more source
Nanoporous silica-based protocells at multiple scales for designs of life and nanomedicine. [PDF]
, 2015 Various protocell models have been constructed de novo with the bottom-up approach. Here we describe a silica-based protocell composed of a nanoporous amorphous silica core encapsulated within a lipid bilayer built by self-assembly that provides for ...
Brinker, C Jeffrey +3 more
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CA: A Cancer Journal for Clinicians, Volume 76, Issue 1, January/February 2026.Abstract Pancreatic ductal adenocarcinoma (PDAC) is an aggressive malignancy with a dismal prognosis, largely because of late‐stage diagnosis and therapeutic resistance. PDAC incidence has been rising, with modifiable and non‐modifiable risk factors contributing to disease development.
Alessandro Mannucci, Ajay Goel
wiley +1 more source
Hypertrophic cardiomyopathy in an adult patient with Noonan syndrome with multiple lentigines
Clinical Case Reports, 2023 Key Clinical Message Noonan syndrome with multiple lentigines (NSML) is a rare RASopathy caused by pathogenic variants (PV) predominantly in PTPN11 gene.
Pamela Rivero‐García +2 more
doaj +1 more source
Relationship between aetiology and left ventricular systolic dysfunction in hypertrophic cardiomyopathy. [PDF]
, 2017 BACKGROUND: Severe left ventricular (LV) systolic dysfunction is an uncommon complication of hypertrophic cardiomyopathy (HCM) that is associated with poor prognosis.
Biagini +22 more
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LEOPARD syndrome in an infant with severe hypertrophic cardiomyopathy and PTPN11 mutation
Annals of Pediatric Cardiology, 2011 In LEOPARD syndrome, mutations affecting exon 13 of the PTPN11 gene have been correlated with a rapidly progressive severe biventricular obstructive hypertrophic cardiomyopathy (HCM).
Ganigara Madhusudan +2 more
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