Results 211 to 220 of about 319,296 (404)

Congenital leptin deficiency is associated with severe early-onset obesity in humans

Nature, 1997
C. Montague, I. Farooqi, J. Whitehead, M. Soos, H. Rau, N. Wareham, C. Sewter, J. Digby, S. Mohammed, J. Hurst, C. Cheetham, Alison R. Earley#, A. Barnett, J. Prins, S. O’Rahilly   +14 more
semanticscholar   +1 more source

Associations of dietary patterns and obesity development in school‐aged children: results from the CHILD Cohort Study

Obesity, EarlyView.
Abstract Objective We aimed to understand data‐driven dietary patterns in Canadian preschoolers and their impact on obesity development among male and female individuals. Methods In the prospective, population‐based Canadian pregnancy cohort, the CHILD Cohort Study (N = 2219), dietary intake was assessed at age 3 years using a previously developed 112 ...
Zheng Hao Chen, Gabrielle Jacobson, Myrtha E. Reyna, Paula Parvulescu, Russell J. de Souza, Mark R. Palmert, Wendy Lou, Susan C. Campisi, Elinor Simons, Stuart E. Turvey, Theo J. Moraes, Piushkumar J. Mandhane, Padmaja Subbarao, Kozeta Miliku   +13 more
wiley   +1 more source

The NLRP3 inhibitor NT‐0796 enhances and sustains GLP‐1R agonist‐mediated weight loss in a murine diet‐induced obesity model

Obesity, EarlyView.
In mouse diet‐induced obesity models, the brain penetrant NLRP3 inhibitor NT‐0796 enhances and sustains the efficacy of the GLP‐1RA semaglutide, leading to a complete reversal of obesity. This correlates with reduced peripheral inflammation and anti‐neuroinflammatory activities, including a reduction in hypothalamic gliosis suggesting further benefits ...
Peter Thornton, Valérie Reader, Zsofia Digby, John Doedens, Nicola Lindsay, Nicholas Clarke, Alan P. Watt   +6 more
wiley   +1 more source

Leptin Is Not Necessary for Gestation and Parturition But Regulates Maternal Nutrition via a Leptin Resistance State [PDF]

, 1998
Khalid Mounzih
openalex   +1 more source

Metabolic clearance rate of insulin across the glucose tolerance spectrum by race and ethnicity in youth with obesity

Obesity, EarlyView.
Abstract Objective Despite β‐cell failure in youth with dysglycemia (i.e., impaired glucose tolerance [IGT] and type 2 diabetes), fasting insulin (FI) concentrations are elevated. Herein, we examined the following: 1) metabolic clearance rate of insulin (MCRI) in youth with obesity and normal glucose tolerance (NGT) versus those with IGT versus those ...
Wonhee Cho, Fida Bacha, Hala Tfayli, SoJung Lee, Sara F. Michaliszyn, Joon Young Kim, Silva Arslanian   +6 more
wiley   +1 more source

Hormone and Metabolite Changes associated with Extended Breeding Fasts in Male Northern Elephant Seals (Mirounga Angustirostris) [PDF]

, 2012
We measured metabolic hormones and several key metabolites in breeding adult male northern elephant seals to examine the regulation of fuel metabolism during extended natural fasts of over 3 months associated with high levels of energy expenditure. Males
Costa, Daniel P., Crocker, Daniel E., Houser, Dorian S., Ortiz, Rudy M., Webb, Paul M.   +4 more
core   +1 more source

Relation between plasma leptin concentration and body fat, gender, diet, age, and metabolic covariates. [PDF]

, 1996
Richard E. Ostlund, JH Yang, Samuel Klein, Ronald L. Gingerich   +3 more
openalex   +1 more source

Effects of obesity‐associated plasma markers on adipose stem cell function and epigenetic regulation

Obesity, EarlyView.
Abstract Objective This study investigates the correlations between obesity‐related plasma markers and epigenetic/inflammatory changes in white adipose tissue (WAT), focusing on adipose‐derived stem cells (ASCs). We hypothesize that obesity modulates histone H3K27 marks, modified by demethylases (lysine‐specific demethylase 6A and 6B [KDM6A/KDM6B]) and
Andressa França Sousa Bispo, Jussara de Jesus Simao, Miguel Ambrizzi Moraes, Ana Beatriz Marques Abel, Victor Tadeu Gonçalves Plata, Monica Marques Telles, André Valente Santana, Paula Volpe, Lucia Maria Armelin‐Correa, Maria Isabel Cardoso Alonso‐Vale   +9 more
wiley   +1 more source

Fabricating Microfluidic Co‐Cultures of Immortalized Cell Lines Uncovers Robust Design Principles for the Simultaneous Formation of Patterned, Vascularized, and Stem Cell‐Derived Adipose Tissue

Small, EarlyView.
Murphy et al present an optimized co‐culture protocol for immortalized cell line vasculogenesis. Here, immortalized co‐cultures form reproducible microvessel networks across 31‐days, while gradient microchips enable simultaneous mesenchymal stem cell (MSC) adipogenesis and endothelial cell (EC) vasculogenesis.
Ashley R. Murphy, Rose Ann Franco, Mark C. Allenby   +2 more
wiley   +1 more source

Serum Leptin Concentration and Insulin Sensitivity in Men with Abdominal Obesity [PDF]

, 1998
Gudmundur Johannsson, Cecilia Karlsson, Lars Lönn, Per Mårin, Per Björntorp, Lars Sjöström, Björn Carlsson, Lena Carlsson, Bengt‐Åke Bengtsson   +8 more
openalex   +1 more source