Results 191 to 200 of about 151,999 (312)

Special Issue "Hormone Signaling in Human Health and Diseases". [PDF]

Int J Mol Sci
Muscella A.
europepmc   +1 more source

Glucocorticoids and HPA axis regulation in the stress–obesity connection: A comprehensive overview of biological, physiological and behavioural dimensions

Clinical Obesity, Volume 15, Issue 2, April 2025.
Summary Chronic stress, characterized by increased long‐term exposure to the glucocorticoid hormone cortisol, is increasingly linked to obesity development. Still, various knowledge gaps persist, including on underlying pathophysiological mechanisms. The aim of the current review is to provide the latest insights on the connection between stress and ...
Robin Lengton, Myrte Schoenmakers, Brenda W. J. H. Penninx, Mariëtte R. Boon, Elisabeth F. C. van Rossum   +4 more
wiley   +1 more source

Postprandial response of leptin and adiponectin to standardized high-carbohydrate and high-fat meals in adults: A cross-sectional study. [PDF]

PLoS One
Del Razo-Olvera FM, Arias-Marroquín AT, Martínez-Fajardo M, Dávila-Olmedo WE, Cruz Bautista I, Galán-Ramírez GA, Juárez-Martínez L, Gómez-Velasco DV, Guillén-Pineda LE, López Estrada A, Otero-Otero R, Elías-López D, Martagón-Rosado AJ, Aguilar-Salinas C, Soto-Mota A.   +14 more
europepmc   +1 more source

Hepatocyte TrkB Acts as a Gatekeeper Against MASH‐Related Liver Fibrosis by Suppressing the TGFβ/CCL2 Axis and Macrophage Infiltration

Cell Proliferation, EarlyView.
Hepatocyte TrkB is identified as a critical gatekeeper against MASH‐related fibrosis. Mechanistically, TrkB inhibits the TGFβ/SMAD3/FOS axis to suppress CCL2 secretion, thereby blocking pathogenic macrophage recruitment and ameliorating liver fibrosis.
Yueying Chen, Jiayi Wei, Shuxuan Li, Kefan Yin, Heming Wang, Yicheng Zhao, Shuqiang Weng, Xizhong Shen, Guangqi Song, Changfeng Zhu, Qunyan Yao, Ling Dong   +11 more
wiley   +1 more source

Leptin antagonism improves Rett syndrome phenotype in symptomatic Mecp2-deficient mice. [PDF]

Neurotherapeutics
Belaïdouni Y, Diabira D, Salin P, Brosset-Heckel M, Valsamides V, Graziano JC, Santos C, Menuet C, Wayman GA, Gaiarsa JL.   +9 more
europepmc   +1 more source

Adipokine profiles and genetic variants of leptin receptor, adiponectin, and ghrelin pathways in obesity: prospective 12-month outcomes after bariatric interventions. [PDF]

Front Endocrinol (Lausanne)
Prodan A, Dzyubanovsky I, Halabitska I, Petakh P, Kamyshna I, Kamyshnyi O.   +5 more
europepmc   +1 more source

Intragastric Balloon Treatment Enhances Weight Maintenance Adjunct to Low‐Energy Diet and Group‐Based Cognitive Behavioural Therapy: A Randomized Controlled Trial

Diabetes, Obesity and Metabolism, EarlyView.
ABSTRACT Aims Low‐energy diet (LED) plus cognitive‐behavioural therapy (CBT) produces substantial short‐term weight loss in obesity, but long‐term maintenance remains difficult. We evaluated whether adding intragastric balloon (IGB) treatment to group‐based CBT improves weight maintenance after initial weight loss using LED.
Marije Galavazi, Qays Shahed, Hugo Hesser, Yang Cao, Stefan Jansson, Michiel van Nieuwenhoven, Johan Jendle   +6 more
wiley   +1 more source

Cross-talk between inflammation and coagulation in severe COVID-19: Association of leptin and classical pro-inflammatory markers with coagulation disorders in a single-center observational cohort study. [PDF]

Medicine (Baltimore)
Boicean LC, Birlutiu RM, Birlutiu V.
europepmc   +1 more source

Investigating the Incremental Cost and Utilization Burden of Obstructive Sleep Apnea in Overweight to Severely Obese Patients

Diabetes, Obesity and Metabolism, EarlyView.
ABSTRACT Aims To quantify the incremental economic and utilization burden of comorbid obstructive sleep apnea (OSA) within an overweight to severely obese adult population. Material and Methods This retrospective cohort study utilized 2016–2025 IQVIA PharMetrics Plus Closed Health Plan commercial claims data to identify overweight to severely obese ...
Hyung Seok John Kim, Tien Hoang Tran, Christopher N. Schmickl, Julia F. Slejko   +3 more
wiley   +1 more source

Nano-engineered leptin mimetics: a precision approach for treating congenital leptin deficiency with hypothalamic dysregulation. [PDF]

Ann Med Surg (Lond)
Fatima S, Afzal F, Ali U, Talha M, Jaber Amin MH.   +4 more
europepmc   +1 more source