Results 271 to 280 of about 76,631 (314)

Leptin Receptors

2011
The hormone leptin, secreted predominantly from adipose tissue, plays a crucial role in the regulation of numerous neuroendocrine functions, from energy homeostasis to reproduction. Genetic deficiency as a consequence of leptin or leptin receptor mutations, although rare in humans, leads to early onset of chronic hyperphagia and massive obesity.
Elizabeth C, Cottrell, Julian G, Mercer
openaire   +2 more sources

Leptin and its receptors

Journal of Chemical Neuroanatomy, 2014
Leptin is mainly produced in the white adipose tissue before being secreted into the blood and transported across the blood-brain barrier. Leptin binds to a specific receptor (LepR) that has numerous subtypes (LepRa, LepRb, LepRc, LepRd, LepRe, and LepRf).
Nobuhiro, Wada, Satoshi, Hirako, Fumiko, Takenoya, Haruaki, Kageyama, Mai, Okabe, Seiji, Shioda   +5 more
openaire   +2 more sources

The soluble leptin receptor

Best Practice & Research Clinical Endocrinology & Metabolism, 2015
The adipokine leptin realizes signal transduction via four different leptin receptor (OB-R) isoforms. The amount of functionally active OB-R, however, is affected by constitutive shedding of the extracellular domain. The product of the cleavage process, the so-called soluble leptin receptor (sOB-R), is the main binding protein for leptin in human blood
Michael, Schaab, Juergen, Kratzsch
openaire   +2 more sources

Leptin Receptor and Leukemia

Leukemia & Lymphoma, 2000
The receptor for leptin, the gene product of the obese gene, is expressed in hematopoietic stem cells. Leptin stimulates normal myeloid and erythroid development, and is secreted from bone marrow adipocytes, which occupy most of the marrow cavity in humans.
M, Hino, T, Nakao, T, Yamane, K, Ohta, T, Takubo, N, Tatsumi   +5 more
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Leptin, leptin soluble receptor and coronary atherosclerosis

Experimental and Clinical Endocrinology & Diabetes, 2007
AbstractBackground  The adipose tissue‐related hormone leptin plays an important role in the regulation of body weight. The associations of leptin and leptin soluble receptor (sOb‐R) with coronary artery disease (CAD) are not clear.Design  We measured leptin and sOb‐R in 543 consecutive patients (379 men, 164 women) referred for coronary angiography ...
G, Hoefle, C H, Saely, L, Risch, P, Rein, L, Koch, F, Schmid, S, Aczél, T, Marte, P, Langer, H, Drexel   +9 more
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Leptin and Leptin Receptor in Anterior Pituitary Function

Pituitary, 2001
Leptin is a 16 kDa protein that exerts important effects on the regulation of food intake and energy expenditure by interacting with the leptin receptor in the brain and in many other tissues. Although leptin is produced mainly by white adipose tissue, several laboratories have shown low levels of leptin production by a growing number of tissues ...
R V, Lloyd, L, Jin, I, Tsumanuma, S, Vidal, K, Kovacs, E, Horvath, B W, Scheithauer, M E, Couce, B, Burguera   +8 more
openaire   +2 more sources

Homology Modeling of Human Leptin/ Leptin Receptor Complex

Biochemical and Biophysical Research Communications, 2000
Leptin receptor mediates the weight regulatory signal carried by the adipocyte-secreted peptide hormone, leptin. It is important to understand the atomic interactions between leptin and the receptor for the therapeutic applications. However, the structure of leptin receptor has not yet been determined. Leptin shows structural similarity to G-CSF, while
T, Hiroike, J, Higo, H, Jingami, H, Toh
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Human mast cells express leptin and leptin receptors

Histochemistry and Cell Biology, 2009
Mast cells are immune cells that produce and secrete a variety of mediators and cytokines that influence various inflammatory and immune processes. Leptin is a cytokine regulating metabolic, endocrine as well as immune functions via the leptin receptor which is expressed by many immune cells.
Taildeman, Jasmien, Perez-Novo, Claudina A., Rottiers, Isabelle, Ferdinande, Liesbeth, Waeytens, Anouk, De Colvenaer, Veerle, Bachert, Claus, Demetter, Pieter, Waelput, Wim, Braet, Katleen, Cuvelier, Claude A.   +10 more
openaire   +4 more sources

[Leptin Receptor].

Nihon rinsho. Japanese journal of clinical medicine, 1998
Leptin is a fat cell-derived satiety factor that regulates food intake and energy expenditure. Its effects are mediated by interactions with the leptin receptor (Ob-R) that is alternatively spliced to encode at least five isoforms(a-e), which are distributed in a wide range of tissues including the hypothalamus.
K, Takaya, Y, Ogawa, H, Masuzaki, N, Matsuoka, K, Hosoda, K, Nakao   +5 more
openaire   +1 more source

Serum leptin levels, skin leptin and leptin receptor expression in psoriasis

British Journal of Dermatology, 2008
Recent studies support the relation of psoriasis with obesity and cardiovascular disease. Leptin, a peptide hormone secreted predominantly from adipose tissue, is involved in the regulation of energy intake and expenditure. Recently, it has been shown to have several immunological effects including induction of proinflammatory cytokine production.To ...
A A, Cerman, S, Bozkurt, A, Sav, A, Tulunay, M O, Elbaşi, T, Ergun   +5 more
openaire   +2 more sources