Results 51 to 60 of about 40,192 (253)
Endothelial Cell Proteins as Biomarkers in Susac Syndrome
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective Susac syndrome (SS) is a rare CD8+ T cell–mediated microangiopathy affecting the brain, retina, and auditory labyrinth. Endothelial injury is thought to be a central mechanism; however, no circulating disease biomarkers are known. We performed targeted proteomic profiling to identify circulating endothelial‐associated proteins as ...
Rohit Benjamin +11 more
wiley +1 more source
Glioma with Leptomeningeal Spread Mimics Chronic Meningoencephalitis in a Young Adult
Case Reports in Neurology, 2021 The most malignant type of intrinsic brain tumor is glioblastoma (WHO grade IV). Primary leptomeningeal spread is rare and leads to a variety of differential considerations, as there is no typical clinical or imaging pattern.
Ann-Kristin Becker +3 more
doaj +1 more source
Immunohistochemical staining for Aβ of leptomeninges, leptomeningeal, and cortical blood vessels.
, 2018 (A) Extensive Aβ deposition in leptomeninges and leptomeningeal blood vessels and their distal branches; APP21 (B) and WT (C) rats did not have Aβ deposits in leptomeningeal or cortical blood vessels.
Yuksel Agca (3437426) +5 more
core +1 more source
Diffuse MRI Edema Predicts Relapse in Cerebral Amyloid Angiopathy–Related Inflammation
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective To identify MRI predictors of relapse and quantify relapse and mortality risk in cerebral amyloid angiopathy–related inflammation (CAA‐RI). A secondary objective was to assess the association between mycophenolate mofetil use and relapse risk. Methods We performed a retrospective cohort study of 36 patients with CAA‐RI treated at the
G. Abbas Kharal +10 more
wiley +1 more source
Suprasellar pilocytic astrocytoma with leptomeningeal dissemination
South African Journal of RadiologyLeptomeningeal dissemination is a rare manifestation of pilocytic astrocytoma. It may occur with higher-grade tumours like medulloblastoma, ependymoma and high-grade glioma, but is extremely rare with low-grade glioma.
Siti S. Mohamad Zaini +4 more
doaj +1 more source
Phase II study of ipilimumab and nivolumab in leptomeningeal carcinomatosis
Nature Communications, 2021 Leptomeningeal metastases from solid tumors are a rare complication with a very poor prognosis. Here the authors report the efficacy and safety of combined ipilimumab and nivolumab in patients with leptomeningeal carcinomatosis.
Priscilla K. Brastianos +29 more
doaj +1 more source
CT of diffuse leptomeningeal metastasis from primary extracerebral neuroblastoma
, 1993 Leptomeningeal metastasis due to primary extracerebral neuroblastoma is rare. Diffuse leptomeningeal contrast enhancement resulting from this condition has been demonstrated only in a recent case report utilizing cranial CT imaging.
Sener, Rn, Sener R.N.
core +1 more source
Investigation of Complement Activation and Cytokine Signatures in AQP4+ NMOSD, MOGAD, and MS
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective Aquaporin‐4‐IgG seropositive neuromyelitis optica spectrum disorder (AQP4+ NMOSD), myelin oligodendrocyte glycoprotein antibody‐associated disease (MOGAD), and multiple sclerosis (MS) are pathophysiologically distinct neuroinflammatory disorders. Complement activation is a major mechanism of injury in AQP4+ NMOSD, whereas its role in
Angeliki G. Filippatou +23 more
wiley +1 more source
, 2017 Background: Elevated vascular endothelial growth factor (VEGF) was associated with poor prognosis in leptomeningeal carcinomatosis and anti-angiogenic therapy was found to prolong the survival of mice in preclinical studies.
Wu, Pei-Fang;Lin, Ching-Hung;Kuo, Ching-Hua;Chen, Wei-Wu;Yeh, Dah-Cherng;Liao, Hsiao-Wei;Huang, Shu-Min;Cheng, Ann-Lii;Lu, Yen-Shen +1 more
core +1 more source
Advanced Science, EarlyView.The protein aggregates and gene expression in the middle temporal gyrus (MTG) and somatosensory cortex (SOM) of the postmortem brains of 13 Alzheimer's disease patients were studied in detail, revealing that small hyperphosphorylated tau aggregates increase with Braak stage driven by microglial inflammation.
Elizabeth A. English +9 more
wiley +1 more source