Results 81 to 90 of about 40,192 (253)

Leptomeningeal Carcinomatosis: A Diagnosis Challenge

Diagnostic Cytopathology, EarlyView.
ABSTRACT Background Leptomeningeal carcinomatosis (LC) in patients with disseminated cancer has a grave prognosis and limited therapeutic options. Diagnosis is delayed due to low CSF volume and scant cellularity. This quality improvement project was undertaken to evaluate the diagnostic performance of CSF cytology in cases with radiologic evidence and ...
Makayla Hyde, Christine F. Lauro, Aaron McConeghey, Laurentia Nodit   +3 more
wiley   +1 more source

Clinical Insights into Neurosyphilis Patients with Leptomeningeal Enhancement of Spinal Cord [PDF]

Wenjing Zhang,1,2,* Xiaoyang Ma,1,2,* Kaiyu Qin,1,2 Cheng Kou,1,2 Canglin Song,1,2 Dongmei Xu1,2 1National Center for Infectious Disease, Beijing Ditan Hospital Capital Medical University, Beijing, People’s Republic of China; 2Department of ...
Zhang W, Kou C, Qin K, Ma X, Xu D, Song C   +5 more
core  

Pediatric new‐onset seizure‐like events: Yield of diagnostic work‐up

Epileptic Disorders, EarlyView.
Abstract Objective To assess the diagnostic yield of ancillary investigations in children presenting with new‐onset seizure‐like events (SLEs) at a tertiary first seizure clinic (FSC). Methods We conducted a retrospective cohort study including 1213 children evaluated for new‐onset SLEs at a tertiary FSC.
Geertruida Slinger, Lotte Noorlag, Willem M. Otte, Maeike Zijlmans, Rosalie L. Neijzen, Sandra M. A. van der Salm, Floor E. Jansen, Kees P. J. Braun, Eric van Diessen   +8 more
wiley   +1 more source

Neuroborreliosis Mimicking Leptomeningeal Carcinomatosis in a Patient With Breast Cancer

Journal of Investigative Medicine High Impact Case Reports, 2014
Leptomeningeal carcinomatosis is a serious complication of advanced cancer. Various clinical manifestations may present, such as headache, nausea, seizures, cranial neuropathies.
Stefanie Fischer MD, Johannes Weber MD, Isabelle Senn-Schönenberger MD, Thomas Cerny MD, Thomas Hundsberger MD   +4 more
doaj   +1 more source

Experimental Treatments for Leptomeningeal Metastases from Solid Malignancies

, 2017
Background: Leptomeningeal metastasis is a consequence of advanced solid malignancies and has limited treatment options. It is possible that it is becoming more common as the leptomeninges act as a sanctuary site for recurrence from systemic cancer ...
Keiran S. Smalley, Smalley, Keiran S., Tran, Nam D., Nam D. Tran, Solmaz Sahebjam, Sahebjam, Solmaz, Forsyth, Peter A., Peter A. Forsyth   +7 more
core   +1 more source

Triphasic waves in leptomeningeal metastases and cycling alternating pattern of encephalopathy during sleep

Epileptic Disorders, EarlyView.
Abstract Background Triphasic waves (TWs), now termed generalized periodic discharges with triphasic morphology, may be mistaken for nonconvulsive status epilepticus (NCSE), particularly in critically ill patients. Changes in vigilance over time can help distinguish encephalopathic patterns from ictal activity.
Philippe Gélisse, Arielle Crespel
wiley   +1 more source

Supplementary Figure from Autocrine GMCSF Signaling Contributes to Growth of HER2⁺ Breast Leptomeningeal Carcinomatosis

, 2021
Supplementary Figure from Autocrine GMCSF Signaling Contributes to Growth of HER2+ Breast Leptomeningeal ...
Motoki Takaku (1414243), Mika Saotome (5028653), Rahul Jandial (327376), Bony De Kumar (14951337), Arunoday Bhan (14951334), Clara Chen (12051830), Khairul I. Ansari (2203792), Antariksh Tyagi (238816)   +7 more
core   +1 more source

Craniofacial Resection for Advanced Cutaneous Squamous Cell Carcinoma: Results From the 2nd International Collaborative Case‐Series

Head &Neck, EarlyView.
ABSTRACT Background Robust outcome data for anterior skull base cutaneous squamous cell carcinoma (cSCC) are limited, particularly as emerging therapies reshape management. We evaluated survival and prognostic factors following craniofacial resection. Methods Retrospective multi‐institutional case‐series (1995–2015) of patients who underwent skull base
Michael J. C. Schachtel, Benedict J. Panizza, James J. Bowman, Catherine Barnett, Cristina Valero, Ian Ganly, Snehal G. Patel, Helena Levyn, Dauren Adilbay, Alana Eagan, Marc A. Cohen, Lillian A. Boe, Junting Zheng, Mithat Gonen, Prathamesh Pai, Paolo Castelnuovo, Fang Ju Gao, Cesare Piazza, Piero Nicolai, Luiz P. Kowalski, Ronaldo N. Toledo, Claudio Cernea, Sergio Goncalves, Dan M. Fliss, John R. de Almeida, Ian Witterick, Philippe Herman, Walter Fontanella, Gregorio Sanchez Aniceto, Alvaro Rivero Calle, Sefik Hosal, Serdar Ozer, Subramania Iyer, Richard J. Harvey, C. Rene Leemans, Jan‐Jaap Hendrickx, Marcelo Figari, Luis Boccalatte, Ken Ichi Nibu, Peter Clarke, Catherine Rennie, Yiming Zhu, Rodney J. Schlosser, Fernando L. Dias, Zoukaa Sargi, Shahzada Ahmed, Wojciech Golusinski, Se Heon Kim, Shirley Y. Su, Shaan M. Raza, Franco DeMonte, Ehab Hanna, Jatin P. Shah   +52 more
wiley   +1 more source

Diffuse Leptomeningeal Glioneuronal Tumor Presenting as Progressive Cranial Neuropathies

, 2022
We present a unique case of Diffuse leptomeningeal glioneuronal tumor (DLGT) presenting as stroke-like symptoms with progressive cranial ...
Mohammad A. Siddiqui; Paul Phillips; Sarkis Nazarian; Raghu Ramakrishnaiah; Murat Gokden; Joseph Chacko
core  

Long‐Term Clinical Response After Low‐Dose and Short‐Duration Cemiplimab Therapy in a Patient With Xeroderma Pigmentosum in Nepal

JEADV Clinical Practice, EarlyView.
Capsule Summary Xeroderma pigmentosum (XP) is associated with a high risk of multiple and aggressive cutaneous squamous cell carcinomas (CSCCs). The immune checkpoint inhibitor cemiplimab has been approved in advanced, unresectable, and/or metastatic CSCCs.
Sudip Parajuli, Arnab Panta, Sabina Bhandari, Anne Grange, Florent Grange, Upama Paudel   +5 more
wiley   +1 more source