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Advances in Diagnosis and Treatment for Leptomeningeal Disease in Melanoma
Current Oncology Reports, 2022Melanoma has one of the highest incidences of causing leptomeningeal disease (LMD) among solid tumors. LMD patients have very poor prognosis with a dismal survival despite aggressive management. In this article, we review the current approaches in the management of patients with LMD secondary to melanoma, including updates in diagnosis, treatment, up ...
Yolanda, Piña +5 more
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Leptomeningeal disease in chronic lymphocytic leukemia
Clinical Neurology and Neurosurgery, 2007Chronic lymphocytic leukemia (CLL) is the most common lymphoproliferative disorder in the western hemisphere, with an annual incidence of 3:100000. Commonly patients are asymptomatic but not rarely disease progression occurs in the setting of lymphadenopathy and extensive leukemic burden.
C P E, Lange +3 more
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Leptomeningeal disease as a manifestation of CLL.
Journal of Clinical Oncology, 2012e17019 Background: Chronic Lymphocytic Leukemia is a lymphoproliferative disorder which can have variable course from being indolent to aggressive. Reported annual incidence of Chronic Lymphocytic Leukemia is 3:100000. The most common manifestation is Lymphadenopathy and Leptomeningeal involvement is very rare with only a few reported cases in ...
Aisha Salman Zaidi +2 more
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Spinal Leptomeningeal Neoplastic Disease
European Neurology, 2008Out of 16 patients, spinal leptomeningeal neoplastic disease was diagnosed by MRI in 4 patients, myelography in 14 patients and CT myelography in 12 cases. MR was superior to myelography in 2 patients, in another 2 patients MRI was equally diagnostic. The cerebrospinal fluid of every patient contained malignant cells.
B. Schuknecht +3 more
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The Potential of Liquorpheresis to Treat Leptomeningeal Disease
World NeurosurgeryLeptomeningeal disease (LMD) is a devastating sequela of many cancers, with an extremely poor prognosis. Barriers to improving outcomes are related to the inability of many traditional therapies to effectively reach the cerebrospinal fluid (CSF) space within the central nervous system.
Victor M. Lu +2 more
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Lymphomatous Leptomeningitis as a Presenting Syndrome of Hodgkin's Disease
Annals of Internal Medicine, 1983Excerpt Patients with Hodgkin's disease may have neurologic symptoms without tumor involvement, or the disease may extend into the nervous system. Intracerebral disease is uncommon (1, 2).
P G, Steinherz +6 more
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Evaluation and Workup of Leptomeningeal Disease
2018Leptomeningeal disease (LMD) is a devastating complication of cancer and a challenge to treat. This chapter addresses the evaluation and workup of LMD. Since a timely diagnosis can make a difference in the patient’s function and quality of life, it is imperative to be aware of the clinical presentation and diagnostic evaluation of LMD as it is a ...
Sushma Bellamkonda, David M. Peereboom
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Focal leptomeningeal vascular anomalies on brain MRI: A mimic of leptomeningeal metastatic disease
Neuro-Oncology PracticeAbstract Background The diagnosis of leptomeningeal metastatic disease has major prognostic and therapeutic implications. We report 13 patients with a radiologically distinct kind of focal, enhancing leptomeningeal lesion on brain MRI that mimics leptomeningeal metastatic disease.
Alexandre Boutet +10 more
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Castleman's disease confined to the leptomeninges.
Annals of clinical and laboratory science, 2000We report a rare case of the plasma cell variant of Castleman's disease confined to the leptomeninges in a 42-year-old female. Flow cytometry demonstrated a minor monoclonal kappa light chain population, and conventional Southern blotting confirmed clonal rearrangement of the J(H) immunoglobulin heavy-chain gene.
T J, Cummings +3 more
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