PLoS ONE, 2021 Leptospirosis is a worldwide zoonosis caused by the pathogenic Leptospira spp. Canine and human leptospirosis sometimes occur on Amami Oshima Island, located in the Nansei Archipelago, southwestern Japan; however, information on the causative Leptospira ...
So Shinya +3 more
doaj +1 more source
Investigating the role of the carbon storage regulator A (CsrA) in Leptospira spp.
PLoS ONE, 2021 Carbon Storage Regulator A (CsrA) is a well-characterized post-transcriptional global regulator that plays a critical role in response to environmental changes in many bacteria.
Theerapat Phoka +5 more
doaj +1 more source
BMC Veterinary Research, 2017 Background Leptospirosis is caused by pathogenic spirochetes of the genus Leptospira spp. This zoonotic disease is distributed globally and affects domestic animals, including cattle.
Maria Raquel V. Cosate +10 more
doaj +1 more source
Conservation of the S10-spc-alpha locus within otherwise highly plastic genomes provides phylogenetic insight into the genus Leptospira. [PDF]
PLoS ONE, 2008 S10-spc-alpha is a 17.5 kb cluster of 32 genes encoding ribosomal proteins. This locus has an unusual composition and organization in Leptospira interrogans.
Berta Victoria +6 more
doaj +1 more source
Temperature-Regulated Protein Synthesis by Leptospira interrogans [PDF]
Infection and Immunity, 2001 ABSTRACT Leptospira interrogans is an important mammalian pathogen. Transmission from an environmental source requires adaptations to a range of new environmental conditions in the organs and tissues of the infected host.
J E, Nally, J F, Timoney, B, Stevenson
openaire +2 more sources
Mutations affecting Leptospira interrogans lipopolysaccharide attenuate virulence [PDF]
Molecular Microbiology, 2010 Summary Leptospira interrogans is the causative agent of leptospirosis. Lipopolysaccharide (LPS) is the major outer membrane component of L. interrogans. It is the dominant antigen recognized during infection and the basis for serological classification. The structure of LPS and its role in pathogenesis are unknown. We describe two defined mutants of L.
Gerald L, Murray +5 more
openaire +2 more sources
Transcriptional responses of Leptospira interrogans to host innate immunity: significant changes in metabolism, oxygen tolerance, and outer membrane. [PDF]
PLoS Neglected Tropical Diseases, 2010 BACKGROUND: Leptospira interrogans is the major causative agent of leptospirosis. Phagocytosis plays important roles in the innate immune responses to L. interrogans infection, and L. interrogans can evade the killing of phagocytes.
Feng Xue +8 more
doaj +1 more source
Efficacy of ciprofloxacin against Leptospira interrogans serogroup icterohaemorrhagiae [PDF]
Antimicrobial Agents and Chemotherapy, 1989 Ciprofloxacin activity against Leptospira interrogans serogroup icterohaemorrhagiae was studied in vitro and in an animal model. The MBC of ciprofloxacin was 0.6 microgram/ml. Three of three Syrian hamsters died 8 to 9 days after intraperitoneal challenge with 10(6) leptospires.
I, Shalit, A, Barnea, A, Shahar
openaire +2 more sources
Human Leptospirosis on Reunion Island, Indian Ocean: Are Rodents the (Only) Ones to Blame?
PLoS Neglected Tropical Diseases, 2016 BackgroundAlthough leptospirosis is a zoonosis of major concern on tropical islands, the molecular epidemiology of the disease aiming at linking human cases to specific animal reservoirs has been rarely explored within these peculiar ecosystems ...
Vanina Guernier +9 more
doaj +1 more source
Characterization of Three Novel Adhesins of Leptospira interrogans [PDF]
The American Society of Tropical Medicine and Hygiene, 2013 We report cloning, expression, purification, and characterization of three predicted leptospiral membrane proteins (LIC11360, LIC11009, and LIC11975). In silico analysis and proteinase K accessibility data suggest that these proteins might be surface exposed.
Gabriela H, Siqueira +5 more
openaire +2 more sources