BMC Veterinary Research, 2017 Background Leptospirosis is caused by pathogenic spirochetes of the genus Leptospira spp. This zoonotic disease is distributed globally and affects domestic animals, including cattle.
Maria Raquel V. Cosate +10 more
doaj +1 more source
Effect of exposure to Neospora caninum, Salmonella, and Leptospira interrogans serovar Hardjo on the economic performance of Irish dairy herds [PDF]
, 2015 peer-reviewedThe objective of the current study was to quantify the effects of exposure to Salmonella, Neospora caninum, and Leptospira interrogans serovar Hardjo (L.
O'Doherty, Eugene +3 more
core +1 more source
Conservation of the S10-spc-alpha locus within otherwise highly plastic genomes provides phylogenetic insight into the genus Leptospira. [PDF]
PLoS ONE, 2008 S10-spc-alpha is a 17.5 kb cluster of 32 genes encoding ribosomal proteins. This locus has an unusual composition and organization in Leptospira interrogans.
Berta Victoria +6 more
doaj +1 more source
Temperature-Regulated Protein Synthesis by Leptospira interrogans [PDF]
Infection and Immunity, 2001 ABSTRACT Leptospira interrogans is an important mammalian pathogen. Transmission from an environmental source requires adaptations to a range of new environmental conditions in the organs and tissues of the infected host.
J E, Nally, J F, Timoney, B, Stevenson
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Transcriptional responses of Leptospira interrogans to host innate immunity: significant changes in metabolism, oxygen tolerance, and outer membrane. [PDF]
PLoS Neglected Tropical Diseases, 2010 BACKGROUND: Leptospira interrogans is the major causative agent of leptospirosis. Phagocytosis plays important roles in the innate immune responses to L. interrogans infection, and L. interrogans can evade the killing of phagocytes.
Feng Xue +8 more
doaj +1 more source
Investigating the role of the carbon storage regulator A (CsrA) in Leptospira spp.
PLoS ONE, 2021 Carbon Storage Regulator A (CsrA) is a well-characterized post-transcriptional global regulator that plays a critical role in response to environmental changes in many bacteria.
Theerapat Phoka +5 more
doaj +1 more source
Temporal trends in bulk milk antibodies to Salmonella, Neospora caninum, and Leptospira interrogans serovar hardjo in Irish dairy herds [PDF]
, 2012 peer-reviewedBulk milk samples were collected from 309 Irish dairy herds at four time points during 2009 and tested for antibodies to Salmonella spp., N. caninum, and L. hardjo, three abortifacient agents in Irish dairy herds. Of the 312 study herds, 49%
O'Doherty, Eugene +2 more
core +1 more source
Mutations affecting Leptospira interrogans lipopolysaccharide attenuate virulence [PDF]
Molecular Microbiology, 2010 Summary Leptospira interrogans is the causative agent of leptospirosis. Lipopolysaccharide (LPS) is the major outer membrane component of L. interrogans. It is the dominant antigen recognized during infection and the basis for serological classification. The structure of LPS and its role in pathogenesis are unknown. We describe two defined mutants of L.
Gerald L, Murray +5 more
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Spirochetal Lipoproteins and Immune Evasion. [PDF]
, 2017 Spirochetes are a major threat to public health. However, the exact pathogenesis of spirochetal diseases remains unclear. Spirochetes express lipoproteins that often determine the cross talk between the host and spirochetes.
Boyadjian, Ani +2 more
core +1 more source
Efficacy of ciprofloxacin against Leptospira interrogans serogroup icterohaemorrhagiae [PDF]
Antimicrobial Agents and Chemotherapy, 1989 Ciprofloxacin activity against Leptospira interrogans serogroup icterohaemorrhagiae was studied in vitro and in an animal model. The MBC of ciprofloxacin was 0.6 microgram/ml. Three of three Syrian hamsters died 8 to 9 days after intraperitoneal challenge with 10(6) leptospires.
I, Shalit, A, Barnea, A, Shahar
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