Results 101 to 110 of about 21,570 (177)

NFS1 Regulates IDH2 to Attenuate Abdominal Aortic Aneurysms via Interacting With SP2

Advanced Science, Volume 13, Issue 14, 9 March 2026.
The loss of NFS1 leads to its reduced binding with the transcription factor SP2, resulting in decreased expression of the downstream gene Idh2. This causes a shift in energy supply toward glycolysis in VSMCs, ultimately contributing to the occurrence and progression of AAA.
Luzheng Zhang, Yu Zhang, Dezhong Wen, Suxiang Guo, Xiaohui Qi, Heng Wang, Yujin Sun, Guangdong Yang, Yuehong Wang, Song Xue   +9 more
wiley   +1 more source

Platelet Rubicon Bidirectional Regulation of GPVI and Integrin αIIbβ3 Signaling Mitigates Stroke Infarction Without Compromising Hemostasis

Advanced Science, Volume 13, Issue 16, 18 March 2026.
This study identifies Rubicon as a key platelet protein that bidirectionally regulates GPVI and integrin αIIbβ3 signaling. Platelet Rubicon protects against cerebral ischemia‐reperfusion injury by limiting infarction without increasing hemorrhage.
Xiaoyan Chen, Jingke Li, Yangyang Liu, Li Li, Xin Deng, Yilin Sheng, Xianyu Zhu, Xiao Jiang, Wei Li, Xueli Cai, Qiming Sun, Hu Hu   +11 more
wiley   +1 more source

Microglial Fkbp5 Impairs Post‐Stroke Vascular Integrity and Regeneration by Promoting Yap1‐Mediated Glycolysis and Oxidative Phosphorylation

Advanced Science, Volume 13, Issue 16, 18 March 2026.
A post‐stroke perivascular niche of microglia characterized by low expression of M2 markers and elevated glycolysis, oxidative phosphorylation (OXPHOS), and phagocytic activity is identified, which is termed stroke‐activated vascular‐associated microglia (stroke‐VAM).
Yanan Li, Yanmei Qiu, Yunlei Yang, Yanhao Wei, Haokun Peng, Longhai Zeng, Pengcheng Li, Rentang Bi, Bo Hu   +8 more
wiley   +1 more source

Ischaemia-reperfusion dynamics in acute myocardial infarction experimental swine model: new insights from quantitative CMR. [PDF]

Eur Heart J Imaging Methods Pract
Viallon M, Petrusca L, Duchateau N, Augeul L, Ovize M, Mewton N, Croisille P.   +6 more
europepmc   +1 more source

Cardiovascular exercise mitigates reperfusion failure and persistent hypoperfusion in the thrombin model of stroke and thrombolysis. [PDF]

J Cereb Blood Flow Metab
Middleham W, Binder NF, Deseö J, Weber R, Zolotko K, Droux J, Yoshihara H, Wyss MT, Luft AR, Weber B, Razansky D, El Amki M, Wegener S.   +12 more
europepmc   +1 more source

Prospective, Multicenter Evaluation of Transcarotid Artery Revascularization in Standard‐Risk Patients: 30‐Day Outcomes of the ROADSTER 3 Study

Annals of Neurology, Volume 99, Issue 3, Page 705-712, March 2026.
Objective To evaluate the real‐world safety and efficacy for standard surgical risk patients with extracranial internal carotid artery disease undergoing transcarotid artery revascularization. Methods ROADSTER 3 is a prospective, multicenter, single‐arm post‐approval study.
Jeffrey Jim, Meghan Dermody, Brian Peterson, Scott S. Berman, Nicolas J. Mouawad, Joseph Ricotta, Naveed Saqib, Peter Faries, Angela Martin, Joshua D. Adams, Uttam Tripathy, Daniel Calderon, David O'Connor, Rasesh Shah, Sumaira Macdonald, Marc L. Schermerhorn   +15 more
wiley   +1 more source

Early Post-Thrombectomy MRI Markers: Temporal Evolution and Association With Reperfusion and Clinical Outcome. [PDF]

Neurology
Luby ML, Hsia AW, Somani S, Lomahan CA, Kim Y, Burton SP, Craft V, Thomas LC, Uche V, Dhawan A, Hildreth M, Pajunar M, Sowers B, Cabatbat R, Kline M, De Vis JB, Merino JG, Wright CB, Lynch JK, Gottesman RF, Latour LL.   +20 more
europepmc   +1 more source

Comparison of the effects of direct and remote ischemic post and preconditioning in the kidney of young rats: histological and laboratory evaluation. [PDF]

Acta Cir Bras
Oliveira AHA, Paula DM, Serafini S, Tannuri U, Tannuri ACA.   +4 more
europepmc   +1 more source

Recurrent Constellations of Embryonic Malformations (RCEM): Teratogenicity Linked to Transient Hypoxia and Hormone Pregnancy Tests Agrees With RCEM and Suggest a Reactive Oxygen Species Pathogenesis

Birth Defects Research, Volume 118, Issue 3, March 2026.
ABSTRACT Background No consistent genetic etiology has been found for a group of six different conditions in humans with multiple malformations called “recurrent constellations of embryonic malformations” (RCEM). Recent studies indicate hypoxia/reoxygenation and generation Reactive Oxygen Species (ROS) as an underlying mechanism for RCEM with the ...
Aaron P. Adam, Helen E. Ritchie, Margaret P. Adam, Bengt R. Danielsson   +3 more
wiley   +1 more source

Regulating the Impact of Hypertension on Stroke: Therapeutic Potential of a Peptide Mimetic of Tyrosine Phosphatase STEP. [PDF]

J Am Heart Assoc
Choi SW, Rajagopal S, Paramasivam P, Poddar R, Paul S.   +4 more
europepmc   +1 more source