Results 81 to 90 of about 22,542 (173)

Preclinical Evaluation of Berry Extracts as a Nutritional Intervention to Alleviate Myocardial Ischemia–Reperfusion Injury and Atherosclerosis Development

Phytotherapy Research, EarlyView.
Schematic representation of the experimental design and the proposed mechanisms underlying the cardioprotective and anti‐atherosclerotic effects of Greek‐derived berry extracts. C57BL/6 mice with WD–induced MS and ApoE−/− mice with atherosclerosis received chronic supplementation with WMex or BBex.
Lydia Symeonidi, Panagiota‐Efstathia Nikolaou, Panagiotis Stathopoulos, Andriana Christodoulou, Alexandra Svouraki, Panagiotis Efentakis, Christina Chania, Angeliki Choustoulaki, Maria Xenaki, Anna Agapaki, Maria Tsoumani, Nikolaos Kostomitsopoulos, Ioulia Tseti, Gemma Vilahur, Alexios‐Leandros Skaltsounis, Ioanna Andreadou   +15 more
wiley   +1 more source

Chrysin Mitigates Acetamiprid‐Induced Testicular Injury in Mice via Suppression of Endoplasmic Reticulum Stress and Inflammation

Environmental Toxicology, EarlyView.
ABSTRACT Acetamiprid (ACP) is a neonicotinoid pesticide that is extensively utilized for the management of insect populations, but its toxic effects on the male reproductive system have become a source of concern. Chrysin (CHR) is a natural flavone found in many plants and bee products, including honey and propolis.
Selim Demir, Nihal Turkmen Alemdar, Esin Yulug, Ali Kulaber, Elif Ayazoglu Demir, Nadire Sevdenur Erdogan, Ahmet Mentese, Yuksel Aliyazicioglu   +7 more
wiley   +1 more source

Impacto de las lesiones por isquemia-reperfusión en la supervivencia alejada de ratas con trasplante intestinal

Acta Gastroenterológica Latinoamericana, 2011
Introducción. El intestino es un órgano altamente sensible a la injuria por isquemia y reperfusión (I-R) y responde de manera temprana aumentando su permeabilidad. Posteriormente, esta respuesta se traduce en cambios morfológicos e histológicos que ponen
Natalia Lausada, Pablo Stringa, Ana Cabanne, Diego Ramisch, Mariana Machuca, Flavio Galvao, Silvia Coronato, Jorge Clemente Raimondi, Gabriel Gondolesi   +8 more
doaj  

Staging concept for aging management: Definition, mechanism, and coping strategies

VIEW, EarlyView.
We divided the overall aging stage into “pre‐aging”, “aging compensation”, and “aging disability”. For each stage, we delineate the clinical presentations, biological phenomena, theoretical underpinnings, and key management priorities. Abstract Aging, as a gradual and largely irreversible biological process, characterized by declining organismal ...
Zhonghan Wang, Shixian Liu, Shangyu Du, Xiangran Cui, Bo Chao, Minglei Liu, Minfei Wu   +6 more
wiley   +1 more source

Targeting T cell metabolism and polarization to modulate post-stroke immune responses and improve outcomes

Frontiers in Immunology
BackgroundT cells drive post-stroke secondary brain injury, with the Th17/Treg balance shaping post-stroke inflammation. Soraphen A (SorA) inhibits Th17 polarization while preserving Tregs.
Juliane Gellrich, Nora Bödecker, Imke Reich, Johanna Ruhnau, Stefan Groß, Susanne H. Kirsch, Susanne H. Kirsch, Rolf Müller, Rolf Müller, Rolf Müller, Juliane Schulze, Antje Vogelgesang   +11 more
doaj   +1 more source

Embolic Agent Selection and Outcomes in Renal Angiomyolipoma Embolisation

Journal of Medical Imaging and Radiation Oncology, EarlyView.
ABSTRACT Purpose To evaluate whether embolic agent selection influences outcomes following selective arterial embolisation (SAE) of renal angiomyolipomas (r‐AMLs) and to assess procedural safety and effects on renal function. Materials and Methods A retrospective observational study was performed of all r‐AML SAEs undertaken at a tertiary institution ...
Ross O'Shea, Himanshu Pendse, Kevin Ho, Hasan Hasan, Ross Vander Wal, Matthys Van Wyk, Jonathan Tibballs, Gurjeet Dulku   +7 more
wiley   +1 more source

MRI-based microthrombi detection in stroke with polydopamine iron oxide

Nature Communications
In acute ischemic stroke, even when successful recanalization is obtained, downstream microcirculation may still be obstructed by microvascular thrombosis, which is associated with compromised brain reperfusion and cognitive decline.
Charlène Jacqmarcq, Audrey Picot, Jules Flon, Florent Lebrun, Sara Martinez de Lizarrondo, Mikaël Naveau, Benoît Bernay, Didier Goux, Marina Rubio, Aurélie Malzert-Fréon, Anita Michel, Fabienne Proamer, Pierre Mangin, Maxime Gauberti, Denis Vivien, Thomas Bonnard   +15 more
doaj   +1 more source

Thrombocytosis and the generation of platelet‐derived microparticles in the pathophysiology of sickle cell disease

British Journal of Haematology, EarlyView.
Thrombocytosis is associated with an increased production of platelet‐derived microparticles from activated platelets, which contribute to vaso‐occlusion in sickle cell disease by perpetuating the cycle of inflammation, procoagulant state and endothelial dysfunction.
Giao N. Lê, Anna Dillon, Owen P. Smith, Corrina McMahon   +3 more
wiley   +1 more source

Downregulation of MLL1 Promotes Intestinal Epithelial Barrier Repair Through Gata4/Bmp4 Activation to Ameliorate Crohn's Disease‐Like Colitis in Mice

Cell Proliferation, EarlyView.
This study elucidates the pivotal regulatory role and mechanism of MLL1 in inflammatory bowel disease. Experimental data demonstrated elevated MLL1 expression levels in TNBS‐induced murine colitis models, with pharmacological inhibition of MLL1 significantly promoting recovery from CD‐like colitis by accelerating intestinal barrier restoration ...
Xue Song, Jing Li, Yue Chen, Bohan Li, Yi Yang, Xiaofan Guan, Xiaofeng Zhang, Lu Tao, Zhijun Geng, Lugen Zuo, Yueyue Wang, Lian Wang, Jianguo Hu   +12 more
wiley   +1 more source

Proteolytic remodelling of the extracellular matrix by pericytes

The FEBS Journal, EarlyView.
Pericytes are specialised perivascular cells intimately connected with endothelial cells and essential for the maintenance of vascular beds. They contribute to the formation and remodelling of the extracellular matrix by actively secreting proteases and protease inhibitors.
Tina Burkhard, Ella Milne, Kate Qian, Paola Campagnolo, Salvatore Santamaria   +4 more
wiley   +1 more source