Results 31 to 40 of about 2,959,450 (344)

Large tumor suppressor kinase 2 overexpression attenuates 5-FU-resistance in colorectal cancer via activating the JNK-MIEF1-mitochondrial division pathway

open access: yesCancer Cell International, 2019
Background 5-Fluorouracil (5-FU) is a standard treatment for colorectal cancer, but most patients develop 5-FU resistance. Here, we conducted experiments to identify an effective approach to augment 5-FU-based treatment in colorectal cancer in vitro ...
Weilong Yao   +3 more
doaj   +1 more source

Prognostic significance of KLF4 in solid tumours: an updated meta-analysis

open access: yesBMC Cancer, 2022
Background Kruppel-like factor 4 (KLF4) is a zinc finger-containing transcription factor predominantly expressed in terminally differentiated epithelial tissues.
Xiaoya Luo   +4 more
doaj   +1 more source

The Generalized Contrast-to-Noise Ratio: A Formal Definition for Lesion Detectability

open access: yesIEEE Transactions on Ultrasonics, Ferroelectrics and Frequency Control, 2019
In the last 30 years, the contrast-to-noise ratio (CNR) has been used to estimate the contrast and lesion detectability in ultrasound images. Recent studies have shown that the CNR cannot be used with modern beamformers, as dynamic range alterations can ...
Alfonso Rodriguez-Molares   +6 more
semanticscholar   +1 more source

Skin Lesion Segmentation in Dermoscopic Images with Combination of YOLO and GrabCut Algorithm

open access: yesDiagnostics, 2019
Skin lesion segmentation has a critical role in the early and accurate diagnosis of skin cancer by computerized systems. However, automatic segmentation of skin lesions in dermoscopic images is a challenging task owing to difficulties including artifacts
H. Ünver, Enes Ayan
semanticscholar   +1 more source

Progressive multiple sclerosis patients show substantial lesion activity that correlates with clinical disease severity and sex: a retrospective autopsy cohort analysis

open access: yesActa Neuropathologica, 2018
Multiple sclerosis (MS) is a highly heterogeneous disease with large inter-individual differences in disease course. MS lesion pathology shows considerable heterogeneity in localization, cellular content and degree of demyelination between patients.
S. Luchetti   +5 more
semanticscholar   +1 more source

The Evidence for a Causal Link Between Disease and Damaging Behavior in Pigs

open access: yesFrontiers in Veterinary Science, 2022
Damaging behaviors (DB) such as tail and ear biting are prevalent in pig production and reduce welfare and performance. Anecdotal reports suggest that health challenges increase the risk of tail-biting.
Laura A. Boyle   +9 more
doaj   +1 more source

Evaluation of circulating small extracellular vesicles derived miRNAs as biomarkers of early colon cancer: a comparison with plasma total miRNAs

open access: yesJournal of Extracellular Vesicles, 2019
Early diagnosis of colon cancer (CC) is clinically important, as it can significantly improve patients’ survival rate and quality of life. Although the potential role for small extracellular vesicles (sEVs) in early detection of many diseases has been ...
Li Min   +10 more
doaj   +1 more source

Multimodal skin lesion classification using deep learning

open access: yesExperimental Dermatology, 2018
While convolutional neural networks (CNNs) have successfully been applied for skin lesion classification, previous studies have generally considered only a single clinical/macroscopic image and output a binary decision.
J. Yap, William Yolland, P. Tschandl
semanticscholar   +1 more source

Intracellular matrix Gla protein promotes tumor progression by activating JAK2/STAT5 signaling in gastric cancer

open access: yesMolecular Oncology, 2020
Matrix Gla protein (MGP) has been widely reported as an extracellular matrix protein with abnormal expression in various types of cancer. However, the function of intracellular MGP in gastric cancer (GC) cells remains largely unknown.
Mizhu Wang   +9 more
doaj   +1 more source

Vitamin D3 Inhibits Helicobacter pylori Infection by Activating the VitD3/VDR-CAMP Pathway in Mice

open access: yesFrontiers in Cellular and Infection Microbiology, 2020
Helicobacter pylori (H. pylori) infection is closely associated with the occurrence and development of gastric diseases. Therefore, eliminating H. pylori infection should help to prevent gastric diseases.
Anni Zhou   +9 more
doaj   +1 more source

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