Results 121 to 130 of about 1,346 (286)

Targeting Dnmt3a/m5C/RelA Axis Attenuates Microglia Inflammatory Response and Improves Postoperative Recovery in Chronic Compressive Cervical Spinal Cord Injury

Advanced Science, EarlyView.
A pro‐inflammatory microglial subset persists after decompression in chronic compressive cervical spinal cord injury and shows enhanced Dnmt3a‐driven m5C signaling. By stabilizing RelA mRNA, this axis sustains NF‐κB activation and postoperative neuroinflammation.
Tianyu Qin, Yuan Jiang, Yongheng Xie, Huanwei Qu, Wenbin Yan, Jingle Chen, Yining Chen, Huayi Li, Naibo Feng, Jiajun Wu, Chao Zhang, Zhengqi Huang, Ming Shi, Zhihuai Deng, Guozhi Xiao, Houqing Long   +15 more
wiley   +1 more source

Factores asociados a lesiones cervicales no cariosas en pacientes gestantes atendidas en el servicio dental del Centro de Salud de Parcona - Ica, año 2017

, 2017
Se realizó la presente investigación con el objetivo de Identificar cuáles son los factores que están asociados a lesiones cervicales no cariosas en las pacientes gestantes atendidas en el Servicio Dental del Centro de Salud de Parcona - ICA, Año 2017 ...
Bustinza Bernardo, Sergio Alfonso, Policarpo Apolinario, Maileé Gretell, Quispe Apaza, Haydee Angelica   +2 more
core  

Targeting Lipopolysaccharide Transport Induces Membrane Lipid Remodeling and Sensitizes Acinetobacter baumannii to Colistin Treatment

Advanced Science, EarlyView.
This study identifies C4 as a lead inhibitor of the Lpt system. Notably, C4 potentiates colistin activity by disrupting LPS transport and remodeling phospholipid homeostasis, revealing a functional interplay between the Lpt and Mla systems. These findings establish a mechanistic link between Lpt inhibition and membrane lipid remodeling, positioning Lpt–
Jianya Luo, Hetianzi Zhang, Jinju Cai, Shuang Zhou, Haijie Zhang, Zhiqiang Wang, Yuan Liu   +6 more
wiley   +1 more source

Biomimetic Macrophage Cell Membrane‐Based Nanoparticles for Effective Treatment of Glioblastoma Through Boron Neutron Capture Therapy Combined With Immunotherapy

Advanced Science, EarlyView.
ABSTRACT Glioblastoma multiforme (GBM) remains largely incurable due to the blood‐brain barrier (BBB) and immunosuppressive microenvironment. While boron neutron capture therapy (BNCT) selectively eradicates tumor cells via 10B(n, α)‐7Li reactions, its clinical potential in GBM is unrealized because of the suboptimal pharmacokinetics of conventional ...
Jiawen Chen, Haoyu You, Hefa Huang, Huihui Chai, Ruize Zhu, Yun Guan, Qisheng Tang, Tianwen Li, Shan Jiang, Houshi Xu, Peng Wang, Yue Wang, Maoyuan Sun, Beining Liu, Zhen Li, Yulai Zeng, Weiqiu Ping, Yanlin Teng, Songlin Yan, Qinghui Li, Long Gu, Tao Sun, Zhifeng Shi   +22 more
wiley   +1 more source

Pap smear prevalence and that of pre-malignant and malignant cervical lesions amongst women living in the Carmen initiative demonstration area, Bucaramanga, Colombia Prevalencia de uso de citología vaginal y de lesiones premalignas y malignas del cérvix entre las mujeres del área demostrativa Carmen, Bucaramanga, Colombia

Revista Colombiana de Obstetricia y Ginecología, 2006
Objective: Establishing the prevalence of premalignant and malignant cervical lesions amongst women living in the CARMEN initiative demonstration area, Bucaramanga, Colombia. Methodology: A cross-sectional study of 8,015 randomly selected women. Patients
Claudia Janeth Uribe-Pérez, Luis Alfonso Díaz-Martínez, Ricardo Ortiz-Serrano, Erika Eliana Meza-Durán   +3 more
doaj  

[Otorhinolaryngological manifestations in monkeypox]. [PDF]

Acta Otorrinolaringol Esp, 2023
Alegre B, Jubés S, Arango N, Pastene D, Lehrer E, Vilaseca I.   +5 more
europepmc   +1 more source

Light‐Activated Ruthenium Nanoclusters Reprogram the Metabolic‐Quorum Sensing Axis for Precision Periodontitis Therapy

Advanced Science, EarlyView.
Under 660 nm visible light, Ru NCs efficiently photocatalyze nitrate‐to‐ammonium conversion and modulate oral nitrogen metabolism. They precisely perturb Veillonella parvula, block its key support to Porphyromonas gingivalis, and exert an “inhibiting without killing” antivirulence effect.
Jing Zhou, Xiaolin Sun, Chengyu Liu, Yujia Shi, Meiqi Li, Meng Bo, Jingjie Zhai, Chunyan Li, Zhennan Wu, Xue Bai, Lin Wang   +10 more
wiley   +1 more source

Heridas de la base del cuello

Cirugía del Uruguay, 1974
Se presenta una serie de 25 casos de heridas cuyo trayecto se emplaza entre cricoides y primer espacio intercostal, analizándose previamente las partjcularidades anatómicas de la región.
Luis E Bergalli, Juan C Castiglioni
doaj  

Nano‐Backpack Engineered Probiotics with Reactive Oxygen Species–Responsive Tungsten Release for Synergistic Therapy of Inflammatory Bowel Disease

Advanced Science, EarlyView.
An integrated probiotic system is engineered to execute a programmed therapeutic cascade against inflammatory bowel disease. Upon pathological signals, the system sequentially performs ROS scavenging, tungsten release, and selective pathogen suppression, thereby breaking the oxidative stress–dysbiosis cycle to remodel gut microbiota and reinforce ...
Yang Yang, Liucan Wang, Guoqing Chen, Yuanling Zhang, Jiarui Shi, Wenzhe Fan, Min Yu, Jixi Zhang, Hua Yang   +8 more
wiley   +1 more source

Trauma de vía aérea

Cirugía del Uruguay, 2001
Las lesiones de tráquea y bronquios fuente no son una situación frecuente en la urgencia. Se diferencian claramente por la topografía en cervicales (traumas laringotraqueales) e intratorácícas (tráquea y brónquicas).
Roberto Delbene, Luis Moure, G Varela, M F Viera   +3 more
doaj