Results 21 to 30 of about 1,603,635 (269)

European Standard Clinical Practice Guideline and EXPeRT Recommendations for the Diagnosis and Management of Gastroenteropancreatic Neuroendocrine Neoplasms in Children and Adolescents

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Pediatric gastroenteropancreatic neuroendocrine neoplasms (GEP‐NENs) are extremely rare and clinically heterogeneous. Management has largely been extrapolated from adult practice. This European Standard Clinical Practice Guideline (ESCP), developed by the EXPeRT network in collaboration with adult NEN experts, provides (adult) evidence ...
Michaela Kuhlen, Calogero Virgone, Antje Redlich, Michael Abele, Ricardo Lopez‐Almaraz, Tal Ben‐Ami, Ewa Bien, Gianni Bisogno, Maja Mazic Cesen, Andrea Ferrari, Malgorzata A. Krawczyk, Yves Reguerre, Dominik T. Schneider, Ines B. Brecht, Charlotte Rigaud, Bilgehan Yalcin, Rainer Claus, Christian Vokuhl, Constantin Lapa, Jörg Fuchs, Segolene Hescot, Thomas Walter, Julien Hadoux, Daniel Orbach   +23 more
wiley   +1 more source

The Buerger’s rabbit model: a closer step to unravelling thromboangiitis obliterans?

Thrombosis Journal
Objective Thromboangiitis obliterans (TAO) remains clinical challenging due to its rarity and underwhelming management outcomes. This study aimed to describe a novel TAO rabbit model that demonstrates a closer resemblance to TAO.
Jia-Long Li, Kristine J. S. Kwan, Xue-Guang Lin, Jie Wang, Bo Chen, Yi-Jie Lu, Bo Wang, Shi-Shuai Xie, Jiong Zhou, Bo Yu, Ying Deng, Shuai Jiang, Jing-Dong Tang   +12 more
doaj   +1 more source

Genomic Diversity and Clinical Variability in Pediatric Primary Cutaneous Anaplastic Large Cell Lymphoma: A Case Series

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Primary cutaneous anaplastic large cell lymphoma (pcALCL) is a rare pediatric CD30‐positive T‐cell lymphoproliferative disorder with an excellent prognosis, but its genomic drivers are poorly defined. We report three children with skin‐limited disease demonstrating striking molecular heterogeneity, including NPM::ALK, NUP214::FRK, and a novel ...
Shoshana Greenberger, Efrat Bar‐Ilan, Victoria Marcu, Evgeny Grishin, Rinat Yacobi, Aviv Barzilai, Hana Golan, Assaf Arie Barg   +7 more
wiley   +1 more source

Are Fertility Preservation Procedures Before Gonadotoxic Therapy and Hematopoietic Stem Cell Transplantation Feasible and Safe in Very Young Children? A Retrospective Cohort Study

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Fertility preservation (FP) is increasingly integrated into the care of pediatric patients exposed to gonadotoxic therapy or conditioning for hematopoietic stem cell transplantation (HSCT), yet perioperative data in infants and toddlers remain scarce.
Kerstin Saalabian, Yannick Braun, Till‐Martin Theilen, Anke Barnbrock, Theresa Rohm, Fabienne Hammant, Nicole Sänger, Aynura Abbasova‐Semiz, Jan‐Henning Klusmann, Thomas Klingebiel, Udo Rolle, Peter Bader, Henning C. Fiegel, Andrea Jarisch   +13 more
wiley   +1 more source

Endothelial cell iron overload and ferroptosis mediate thrombosis and inflammation through the miR-32-5p/neurofibromin 2 pathway

European Journal of Medical Research
Thromboangiitis obliterans (TAO) is characterized by progressive inflammatory vasculopathy featuring thrombotic occlusion. Aberrant thrombosis induces endothelial damage through pathological clotting, while iron may act as a pro-oxidant cofactor. However,
Ying Deng, Xueguang Lin, Jun Wei, Bo Chen, Huafang Yan, Bo Wang, Jialong Li, Yuqun Zhao, Bo Yu, Jingdong Tang, Shuai Jiang   +10 more
doaj   +1 more source

SLC4A10 impedes atherosclerosis by diminishing IFN-γ/GZMB levels of CD8+ T cells via the MAPK pathway

Frontiers in Immunology
Background and aimsCD8+ T cell subpopulations participate in the formation of atherosclerotic plaques through activation or exhaustion. Yet, it is unclear which specific subset it critically involved.
Bo Chen, Bo Chen, Lei Zhu, Lei Zhu, Xueguang Lin, Xueguang Lin, Kristine J. S. Kwan, Kristine J. S. Kwan, Jie Wang, Jie Wang, Yijie Lu, Yijie Lu, Jialong Li, Jialong Li, Ying Deng, Ying Deng, Shuai Jiang, Shuai Jiang, Jingdong Tang, Jingdong Tang, Bo Yu, Bo Yu, Bo Yu   +22 more
doaj   +1 more source

Non-local means inpainting of MS lesions in longitudinal image processing

Frontiers in Neuroscience, 2015
In medical imaging, multiple sclerosis (MS) lesions can lead to confounding effects in automatic morphometric processing tools such as registration, segmentation and cortical extraction and subsequently alter individual longitudinal measurements ...
Nicolas eGuizard, Kunio eNakamura, Kunio eNakamura, Pierrick eCoupé, Vladimir S. Fonov, Douglas L Arnold, D Louis Collins   +6 more
doaj   +1 more source

Central Nervous System Neuroblastoma, FOXR2‐Activated: A Pooled Analysis of Published Clinical Outcomes

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Central nervous system (CNS) neuroblastoma, FOXR2‐activated, is a recently recognized entity in the WHO CNS5 classification, defined by activation of the FOXR2 transcription factor and unique histopathological features. This review synthesizes available literature and pooled clinical data, providing insight into demographics ...
Sudarshawn Damodharan, Mohamed S. Abdelbaki   +1 more
wiley   +1 more source

Evaluating the potential of phenotypic age to enhance cardiovascular risk prediction over chronological age in the UK Biobank

Scientific Reports
Phenotypic age acceleration (PhenoAgeAccel) is a novel biological indicator estimates an individual’s mortality risk. The primary aim of this study was to evaluate the association between PhenoAge and PhenoAgeAccel with incident cardiovascular diseases ...
Kristine J. S. Kwan, Shi-Shuai Xie, Hai-Lei Li, Xue-Guang Lin, Yi-Jie Lu, Bo Chen, Kai-Xin Ge, Shu-Ya Tang, Hui Zhang, Shuai Jiang, Jing-Dong Tang   +10 more
doaj   +1 more source

Clinical and pathological characteristics of and predictive model for colorectal neuroendocrine tumors

Heliyon
Background: The incidence of colorectal neuroendocrine tumors (NETs) is increasing, causing a social burden. At present, there is no specific prognostic model for colorectal NETs.
Jiuyue Ma, Xiaoqian Ma, Jie Xing, Ruyun Song, Yang Zhang, Mo Liu, Shuilong Guo, Qian Zhang, Jing Wu   +8 more
doaj   +1 more source