Results 41 to 50 of about 2,808,044 (312)

SLC4A10 impedes atherosclerosis by diminishing IFN-γ/GZMB levels of CD8+ T cells via the MAPK pathway

Frontiers in Immunology
Background and aimsCD8+ T cell subpopulations participate in the formation of atherosclerotic plaques through activation or exhaustion. Yet, it is unclear which specific subset it critically involved.
Bo Chen, Bo Chen, Lei Zhu, Lei Zhu, Xueguang Lin, Xueguang Lin, Kristine J. S. Kwan, Kristine J. S. Kwan, Jie Wang, Jie Wang, Yijie Lu, Yijie Lu, Jialong Li, Jialong Li, Ying Deng, Ying Deng, Shuai Jiang, Shuai Jiang, Jingdong Tang, Jingdong Tang, Bo Yu, Bo Yu, Bo Yu   +22 more
doaj   +1 more source

A cross sectional study of prevalence, risk factors, population attributable fractions and pathology for foot and limb lesions in preweaning piglets on commercial farms in England [PDF]

, 2009
Background: In a cross sectional study of 88 indoor and outdoor English pig farms, the prevalence of foot and limb lesions in 2843 preweaning piglets aged 1–4 weeks from 304 litters was recorded.
Kilbride, A. L. (Amy L.), Gillman, Claire E., Ossent, P., Green, Laura E.   +3 more
core   +2 more sources

Clinical Insights Into Hypercalcemia of Malignancy in Childhood

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Hypercalcemia of malignancy (HCM) is a rare but life‐threatening metabolic emergency in children that occurs in less than 1% of pediatric cancer cases, with a reported incidence ranging from 0.4% to 1.0% across different studies. While it is observed in 10%–20% of adult malignancies, pediatric HCM remains relatively uncommon.
Hüseyin Anıl Korkmaz
wiley   +1 more source

Endothelial cell iron overload and ferroptosis mediate thrombosis and inflammation through the miR-32-5p/neurofibromin 2 pathway

European Journal of Medical Research
Thromboangiitis obliterans (TAO) is characterized by progressive inflammatory vasculopathy featuring thrombotic occlusion. Aberrant thrombosis induces endothelial damage through pathological clotting, while iron may act as a pro-oxidant cofactor. However,
Ying Deng, Xueguang Lin, Jun Wei, Bo Chen, Huafang Yan, Bo Wang, Jialong Li, Yuqun Zhao, Bo Yu, Jingdong Tang, Shuai Jiang   +10 more
doaj   +1 more source

Pathogenicity of Salmonella enterica subspecies enterica serovar Enteritidis phage type 1 in one-day-old specific pathogen free chicks

Open Veterinary Journal, 2022
Background and Aim: The studies about Salmonella infection in the newly hatched chicks were not extensive. The objective of this study was to determine pathogenicity of Salmonella enterica subspecies enterica serovar Enteritidis (SE) phage type (PT) 1 in
S. Ahmad, M. Hair-Bejo, Elawad A. Hussein, E. A Awad, Mohamed Ibrahim Saeed, Liew Pit Sze, Zunita Zakaria   +6 more
doaj   +1 more source

Secondary bacterial infections of buruli ulcer lesions before and after chemotherapy with streptomycin and rifampicin [PDF]

, 2013
Buruli ulcer (BU), caused by Mycobacterium ulcerans is a chronic necrotizing skin disease. It usually starts with a subcutaneous nodule or plaque containing large clusters of extracellular acid-fast bacilli.
AA Pahlevan, AB Wysocki, Albert Paintsil, AO Shittu, AO Shittu, AW Bauer, Benjamin Anku, Cynthia Kwakye-Maclean, D Yeboah-Manu, Dorothy Yeboah-Manu, E Coutanceau, E Coutanceau, E Mensah-Quainoo, Evelyn Owusu-Mireku, G Bori, Gerd Pluschke, Grace S. Kpeli, HC Gram, IG Schraibman, Isaac Lamptey, J Guarner, J Hayman, JP Heggers, K GjØdsbØl, K Twum-Danso, KM Dobos, KM George, KM George, Kobina Asan-Ampah, Kwabena Quenin-Fosu, L Katz, M Cruickshank, M Karas, Marie-Thérèse Ruf, MC Robson, Mercy Newman, NA Stotts, NS Levine, Pamela L. C. Small, PG Bowler, RC Daltery, S Adusumilli, S Etuaful, W Curreri, W Majewski, WA Nienhuis   +45 more
core   +3 more sources

Personalized Selumetinib Dosing in Pediatric Neurofibromatosis Type 1: Insights From a Pilot Therapeutic Drug Monitoring Study

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Objective To evaluate selumetinib exposure using therapeutic drug monitoring (TDM) in pediatric patients with neurofibromatosis type 1 (NF1) and plexiform neurofibromas (PN), assess interpatient pharmacokinetic variability, and explore the relationship between drug exposure, clinical response, and adverse effects.
Janka Kovács, Zoltán Köllő, Balázs Gellért Karvaly, Mahmoud Obeidat, Rita Nagy, Péter Hegyi, Brigitta Teutsch, Eszter Tuboly, Miklós Garami   +8 more
wiley   +1 more source

Evaluating the potential of phenotypic age to enhance cardiovascular risk prediction over chronological age in the UK Biobank

Scientific Reports
Phenotypic age acceleration (PhenoAgeAccel) is a novel biological indicator estimates an individual’s mortality risk. The primary aim of this study was to evaluate the association between PhenoAge and PhenoAgeAccel with incident cardiovascular diseases ...
Kristine J. S. Kwan, Shi-Shuai Xie, Hai-Lei Li, Xue-Guang Lin, Yi-Jie Lu, Bo Chen, Kai-Xin Ge, Shu-Ya Tang, Hui Zhang, Shuai Jiang, Jing-Dong Tang   +10 more
doaj   +1 more source

Clinical and pathological characteristics of and predictive model for colorectal neuroendocrine tumors

Heliyon
Background: The incidence of colorectal neuroendocrine tumors (NETs) is increasing, causing a social burden. At present, there is no specific prognostic model for colorectal NETs.
Jiuyue Ma, Xiaoqian Ma, Jie Xing, Ruyun Song, Yang Zhang, Mo Liu, Shuilong Guo, Qian Zhang, Jing Wu   +8 more
doaj   +1 more source

Brain architecture-based vulnerability to traumatic injury

Frontiers in Bioengineering and Biotechnology, 2022
The white matter tracts forming the intricate wiring of the brain are subject-specific; this heterogeneity can complicate studies of brain function and disease.
Jared A. Rifkin, Jared A. Rifkin, Taotao Wu, Adam C. Rayfield, Erin D. Anderson, Matthew B. Panzer, Matthew B. Panzer, David F. Meaney, David F. Meaney   +8 more
doaj   +1 more source