Results 51 to 60 of about 1,670,297 (269)
Neutralization of the PTX3/CD44 axis suppresses TGF‐β1 signaling in kidney fibrosis
FEBS Letters, EarlyView.This study investigates how the PTX3/CD44 axis promotes kidney fibrosis by activating TGF‐β1 signaling. We demonstrate that the neutralizing antibody WHC‐001 effectively inhibits this pathway, suppressing myofibroblast activation and partial epithelial–mesenchymal transition (EMT).
Chao‐Chun Cheng +8 more
wiley +1 more source
Effects of light intensity in different stocking densities on tibial measurements and incidence of lesions in broilers [PDF]
Biotechnology in Animal Husbandry, 2019 The possibility for use of high light intensity in broiler production management to improve the health of broilers' legs was examined in a study aiming to determine the effect of two levels of light intensity in different stocking densities of broiler ...
Škrbić Zdenka +6 more
doaj
The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers
Molecular Oncology, EarlyView.The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce +11 more
wiley +1 more source
The Diagnostic Value of High-Frequency Ultrasound in Unclarified Lesions at the End of Extremities
DiagnosticsObjectives: Unlike other body parts, unclarified lesions at the end of extremities have unique challenges due to their small size and interference. Traditional imaging methods struggle with low resolution.
Haojie Yang +11 more
doaj +1 more source
Clinical and Experimental Dental Research, 2021 Objectives Clinical validation of a bioluminescence imaging system (Cis) as measured by the level of agreement between clinician visual and tactile assessment of carious lesion presence and activity and the presence/absence of elevated luminescence on a ...
Nigel Pitts +4 more
doaj +1 more source
Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment
Molecular Oncology, EarlyView.This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley +1 more source
Toxicologic Pathology, 2011 The diagnosis of a non-neoplastic lesion is usually based on subjective morphologic characteristics of the lesion, which are published and/or based on the pathologist’s training and experiences. Naturally occurring lesions in most animal species typically follow an age-related progression of extent and severity in a specific tissue.
Jerrold M, Ward, Bob, Thoolen
openaire +2 more sources
Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer
Molecular Oncology, EarlyView.Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley +1 more source
Gülhane Tıp DergisiAims: Clinicopathological features of bone and soft tissue tumors/tumor-like lesions have been shown to vary geographically. This study aims to analyze the clinicopathological features of bone and soft tissue lesions in Ilorin, including both neoplastic ...
Mumini Wemimo Rasheed +6 more
doaj +1 more source
Molecular Oncology, EarlyView.Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary +1 more
wiley +1 more source