Results 81 to 90 of about 2,808,044 (312)

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

FEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai, Mizuki Seo, Gyath Karadsheh, Fachrur Rizal Mahendra, Máté Á Demény, Ferenc Győry, János András Mótyán, László Fésüs, Endre Kristóf, Rini Arianti   +9 more
wiley   +1 more source

Elevated GPX3 expression in endometriosis: implications for pathogenesis and immune cell infiltration

European Journal of Medical Research
Introduction Endometriosis (EM) is an inflammatory condition that affects approximately 10% of the female-born population. It is characterized by the presence of endometrial tissue outside the uterine cavity, leading to chronic pelvic pain, dysmenorrhea,
Xiao-gang Mao, Xi Yang, Ya-nan Zhu, Meng-meng Sun, Fan Ye, Shi-ge San, Jian Tang, Liang Shen, Hui Xing, Kun Meng   +9 more
doaj   +1 more source

The usefulness of c-Kit in the immunohistochemical assessment of melanocytic lesions [PDF]

, 2011
C-Kit (CD117), the receptor for the stem cell factor, a growth factor for melanocyte migra- tion and proliferation, has shown differential immunostaining in various benign and malig- nant melanocytic lesions. The purpose of this study is to compare c-Kit
Atzori L, Bianco P, Cabras S, Castellanos ME, Difelice E, Faa G, Ferreli C, Mulas P, Nemolato S, Pilloni L   +9 more
core   +1 more source

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

FEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel, Carl P. O. Helmer, Shani Zev, Ronja Driller, Emily Buhr, Markus Reinbold, Renana Schwartz, Gabriel Foley, Mikael Boden, Daniel Garbe, Gerhard Schenk, Dan Thomas Major, Bernhard Loll, Thomas Brück   +13 more
wiley   +1 more source

In vivo imaging of cellular proliferation in colorectal cancer using positron emission tomography [PDF]

, 2003
Background and aims: Positron emission tomography (PET) using 18F labelled 2-fluoro-2-deoxy-D-glucose (18FDG) is an established imaging tool, although the recent development of a biologically stable thymidine analogue [18F] 3'-deoxy-3-fluorothymidine ...
Costa, D.C., Ell, P.J., Francis, D.L., Freeman, A., Luthra, S.K., Novelli, M., Taylor, I., Visvikis, D.   +7 more
core  

Conservative surgical treatment in cervical dysplastic lesions associated with cystorectocele [PDF]

, 2019
The treatment of cervical intraepithelial neoplasia aims at removing the squamocolumnar junction area, including abnormal tissues, up to the healthy tissue.
Braila, Anca D, Braila, Mihai, Deca, Mihai, Lungulescu, Cristian, Obleaga, Cosmin V, Puca, Bogdan Marian, Saad, Hany   +6 more
core   +2 more sources

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

Molecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice, Jose I. Lopez, Aitziber Ugalde‐Olano, Maite Zufiaurre, Ianire Astobiza, Natalia Martin‐Martin, Laura Bozal‐Basterra, Saioa Garcia‐Longarte, Amaia Zabala‐Letona, Sofia Rey, Aida Santos‐Martin, Miguel Unda, Ana Loizaga‐Iriarte, Mariona Graupera, Paolo Nuciforo, Arkaitz Carracedo, Isabel Mendizabal   +16 more
wiley   +1 more source

Salmonella enterica I 4,[5],12:i:- Associated with Lesions Typical of Swine Enteric Salmonellosis

Emerging Infectious Diseases, 2019
Salmonella enterica serotype I 4,[5],12:i:- has been increasingly isolated from swine. However, its pathogenic potential is not well characterized. Analysis of swine cases confirmed a strong positive association between isolation of I 4,[5],12:i:- and ...
Bailey L. Arruda, Eric R. Burrough, Kent J. Schwartz   +2 more
doaj   +1 more source

Liver resection for metastatic colorectal cancer [PDF]

, 1986
From 1975 to 1985, 60 patients with isolated hepatic metastases from colorectal cancer were treated by 17 right trisegmentectomies, five left trisegmentectomies, 20 right lobectomies, seven left lobectomies, eight left lateral segmentectomies, and three ...
Esquivel, CO, Gordon, RD, Iwatsuki, S, Starzl, TE   +3 more
core  

Follicular nodules (Thy3) of the thyroid: is total thyroidectomy the best option? [PDF]

, 2014
BACKGROUND: Identification of the best management strategy for nodules with Thy3 cytology presents particular problems for clinicians. This study investigates the ability of clinical, cytological and sonographic data to predict malignancy in ...
CALO', PIETRO GIORGIO, ERDAS, ENRICO, Medas F, NICOLOSI, ANGELO, Pisano G, Podda F, Santa Cruz R   +6 more
core   +1 more source