Results 211 to 220 of about 5,585,699 (313)

Lassa fever and Argentine hemorrhagic fever treatment in guinea pigs using broad-spectrum cap-dependent endonuclease inhibitors. [PDF]

mBio
Maruyama J, Taniguchi S, Saito T, Yamada S, Reyna RA, Paroha R, Kobayashi D, Siman-Tov G, Click C, Littlefield K, Toba S, Taoda Y, Shibazaki M, Huang C, Sasaki M, Orba Y, Sawa H, Sato A, Paessler S.   +18 more
europepmc   +1 more source

Introducing global food 50/50: Brief prepared for the UN Food Systems Pre-Summit 2021

Gender equality is a precondition for achieving the world’s shared ambitions of the Sustainable Development Goals by 2030, including delivering sustainable food systems. Gender is intricately linked to all components of food systems.
Global Health 50/50, Njuki, Jemimah, Tanaka, Sonja, International Food Policy Research Institute   +3 more
core  

Targeting the KAT7/H3K14ac/RAC2 Axis Mediates OXPHOS to Promote Stemness Maintenance and Malignancy in Glioblastoma

Advanced Science, EarlyView.
SOX2 upregulates KAT7 in glioma stem cells, where KAT7 deposits H3K14 acetylation at the RAC2 promoter to activate RAC2 transcription. RAC2‐GTP subsequently promotes PAK1/2/3 phosphorylation, increasing tricarboxylic acid cycle flux and mitochondrial respiration to support glioblastoma malignancy.
Jilong Liu, Yanfei Sun, Yuehua Zhu, Guangjing Mu, Jiazheng Wang, Liangliang Wang, Feihu Zhao, Zhimin Zhao, Jian Wang, Ying He, Zheng Jiang, Xingang Li, Mingzhi Han, Bin Huang   +13 more
wiley   +1 more source

The IL-17A/Neutrophil axis plays a critical role in lethal infection induced by an emerging ultra-virulent <i>Streptococcus suis</i> serotype 5 strain. [PDF]

Virulence
Chen G, Zhang X, Wang J, Du P, Sun H, Zheng H, Xu J.   +6 more
europepmc   +1 more source

An Injectable Metal‐Drug Supramolecular Condensate Enables Radiosensitization and Systemic Antitumor Immunity for Post‐Surgical Osteosarcoma Therapy

Advanced Science, EarlyView.
This work designed an injectable metal‐drug supramolecular condensate formed from hafnium ions and alendronate (Hf‐ALN) and loaded with the COX‐2 inhibitor celecoxib (CXB) for synergistic radioimmunotherapy of postoperative osteosarcoma. Mechanistically, upon X‐ray irradiation, Hf enhances radiation energy deposition, ROS generation, and DNA damage ...
Tianhua Xiao, Zunlei Gong, Chuke Chen, Hui Yu, Yu Cai, Can Liu, Hongkai Huang, Ying Li, Jinyuan Guan, Le Wang, Chengyun Ning, Guoxin Tan, Lei Zhou   +12 more
wiley   +1 more source

Post-Exposure JNJ-26366821 Treatment Attenuates Systemic Inflammation and Limits Cardiotoxic Risk. [PDF]

Biomolecules
Chakraborty N, Holmes-Hampton GP, Neff LS, Kumar VP, Kannan S, Cheema AK, Guha C, Ghosh SP, Hammamieh R.   +8 more
europepmc   +1 more source

Intelligent Programmable Membrane Nanosponge for Early Virus Blocking

Advanced Science, EarlyView.
A smart programmable nanosponge (ACNPs) displays high‐density viral receptors on its membrane and encapsulates fusion inhibitors to capture virions at the infection source through competitive binding and blocks their entry through protease inhibition for ultra‐early cascade interception. This modular, mucus‐penetrating platform shifts antiviral defence
Ze Chen, Zhuojun He, Huimin Guo, Min Shi, Ruijing Liang, Lanlan Liu, Yeneng Dai, Qi Zhao, Ke Liu, Yang Zhou, Yang Zhang, Jian Ren, Bin Ju, Quan Fang, Zhaozhen Li, Pengfei Zhao, Mingbin Zheng, Lintao Cai   +17 more
wiley   +1 more source

Venomics of the Anchor Coral Snake <i>Micrurus ancoralis</i>: Composition, Toxicological Profile, and Neutralization by Commercial Antivenom. [PDF]

Trop Med Infect Dis
Rey-Suárez P, Echavarría-Rentería JD, Gómez-Robles J, Pereañez JA, Saldarriaga-Córdoba M, Lomonte B, Fernández J, Núñez V.   +7 more
europepmc   +1 more source

Phase Separation of SF3B1 Serves as a Critical Post‐Transcriptional Regulator During Early Mouse Embryogenesis

Advanced Science, EarlyView.
Phase separation of SF3B1 acts as a key regulatory mechanism for dynamic alternative splicing throughout early mouse embryogenesis. Its absence triggers extensive splicing errors, which induce persistent DNA damage, defective cell cycle progression, and failed cell lineage commitment, and ultimately hinder the normal growth and development of ...
Kang Zhao, Ting‐Yu Han, Yan‐Li Cheng, Yi‐Dan Zhang, Yu‐Wei Zhang, JinJian Guo, ShaoJun Zhang, WenZe Huang, Jing Zhang, Pei‐Yu Liao, Ying Xin, ChuanChen Chu, Qing‐Yuan Sun, ZhiZhen Liu, Xiang‐Hong Ou, Jun Xie   +15 more
wiley   +1 more source

Type I IFN dynamics orchestrate protective ICAM1⁺ neutrophil heterogeneity as an early checkpoint for survival in lethal viral infection. [PDF]

iScience
Saito R, Ding Y, Satou K, Yamamoto F, Satomi A, Sugishita H, Ukai H, Gotoh Y, Okazaki T.   +8 more
europepmc   +1 more source