Results 81 to 90 of about 4,473,042 (255)
Molecular Oncology, EarlyView.Extracellular vesicle (EV) lipidomic profiling of plasma and ascites from patients with high‐grade serous ovarian cancer and of ovarian cancer cell lines reveals enrichment of triglycerides (TGs), diacylglycerols (DGs), phosphatidylcholine (PCs), sphingomyelins (SMs), reflecting tumor metabolic reprogramming.
Shikha Rani +9 more
wiley +1 more source
Molecular Oncology, EarlyView.Loss of eIF5A rewires thapsigargin‐mediated endoplasmic reticulum stress responses in multiple myeloma cells by selective translation of mRNA transcripts, consequently dampening thapsigargin‐induced unfolded protein response (UPR) activation and shifting the balance from induction of apoptosis toward cell survival and proliferation.
Demi Both +7 more
wiley +1 more source
Kinetic energy less lethal weapons and their associated blunt trauma injuries [PDF]
, 2010 A widely used class of Less Lethal Weapon is the kinetic energy projectile. This can cause blunt trauma to the targeted person and, under certain circumstances, its use can result in permanent injury or death.
Tawell, Miles G.
core +2 more sources
Expression and Purification of a Redox-Sensitive Green Fluorescent Protein Fused with Anthrax Toxin Lethal Factor [PDF]
, 2011 Pathogenicity of Anthracis Bacillus is induced by its exotoxin composed of protective antigen (PA) lethal factor (LF) and edema factor (EF) that together target mammalian cells.
Licon^, Ernesto, Sun*, Jianjun
core +1 more source
Molecules, 2011 Matrix-assisted laser-desorption time-of-flight (MALDI-TOF) mass spectrometry (MS) is a valuable high-throughput tool for peptide analysis. Liquid chromatography electrospray ionization (LC-ESI) tandem-MS provides sensitive and specific quantification of
Suzanne Kalb +8 more
doaj +1 more source
Molecular Oncology, EarlyView.Loss of NAPRT promotes lung tumor initiation and growth through a noncanonical mechanism, independent of its role in NAD+ biosynthesis. Mechanistically, NAPRT depletion activates the mTORC2‐driven AKT/β‐catenin signaling axis to enhance clonogenic and invasive phenotypes. Furthermore, lung‐specific Naprt deletion significantly increases tumor burden in
Myung Joon Oh +11 more
wiley +1 more source
Molecular Oncology, EarlyView.In head and neck squamous cell carcinoma (HNSCC) p53 and p63 exert opposite roles on the transcription regulation of the lncRNA NEAT1. Under basal conditions, p53 levels are low and p63 represses NEAT1 expression. Upon genotoxic stress, p53 is rapidly induced, displacing p63 from the NEAT1 promoter leading to NEAT1 transcriptional activation and ...
Sara De Domenico +5 more
wiley +1 more source
Monoclonal Antibody Therapies against Anthrax
Toxins, 2011 Anthrax is a highly lethal infectious disease caused by the spore-forming bacterium Bacillus anthracis. It not only causes natural infection in humans but also poses a great threat as an emerging bioterror agent.
Zhaochun Chen +2 more
doaj +1 more source
Kv11.1-dependent senescence activates a lethal immune response via tumor necrosis factor alpha
Neoplasia: An International Journal for Oncology ResearchUnderstanding the complex relationship between cancer and immune surveillance is essential for leveraging the immune system to control tumor growth.
Maedeh Vakili Saatloo +4 more
doaj +1 more source
Lethal factor in the male mouse submandibular gland
, 1981 The presence of a toxic component (lethal factor) has been reported in the male mouse submandibular gland (SMG). This study was designed to clarify whether the toxic component was secreted into saliva or not and to investigate some characteristics of ...
Masahiko Hiramatsu +2 more
core +1 more source