Results 91 to 100 of about 4,473,042 (255)

p190A/ARHGAP35 and p190B/ARHGAP5 proteins in endometrial cancer: a novel cancer‐relevant paralog interplay

Molecular Oncology, EarlyView.
This study identifies ARHGAP5, in addition to the frequently mutated ARHGAP35, as significantly mutated in endometrial cancer. Mutations in both genes co‐occur and are associated with their correlated downregulation. Functional CRISPR studies show that both paralogs regulate similar pathways, including actin cytoskeleton organization.
Mathilde Pinault, Capucine Heraud, Mélissa Correia de Oliveira, Véronique Neaud, Valérie Valesco, Valérie Prouzet‐Mauleon, Béatrice Turcq, Jean‐William Dupuy, Anne‐Aurélie Raymond, Sabrina Croce, Frédéric Saltel, Valérie Lagrée, Violaine Moreau   +12 more
wiley   +1 more source

The cytokine tumor necrosis factor-like weak inducer of apoptosis and its receptor fibroblast growth factor-inducible 14 have a neuroprotective effect in the central nervous system

Journal of Neuroinflammation, 2012
Background Cerebral cortical neurons have a high vulnerability to the harmful effects of hypoxia. However, the brain has the ability to detect and accommodate to hypoxic conditions. This phenomenon, known as preconditioning, is a natural adaptive process
Echeverry Ramiro, Wu Fang, Haile Woldeab B, Wu Jialing, Yepes Manuel   +4 more
doaj   +1 more source

Aquaporin‐3 and aquaporin‐5 impact the development of pancreatic ductal adenocarcinoma spheroids

FEBS Open Bio, EarlyView.
Schematic representation of the role of aquaporin‐3 (AQP3) and aquaporin‐5 (AQP5) in pancreatic ductal adenocarcinoma (PDAC). Both proteins are upregulated in PDAC and are associated with tumor progression and metastatic potential. Silencing AQP3 or AQP5 in PDAC spheroids results in decreased diameter, area, and overall growth, underscoring their key ...
Catarina Pimpão, Diogo M. Engrácia, Graça Soveral, Filipa Mendes   +3 more
wiley   +1 more source

Late-acting dominant lethal genetic systems and mosquito control. [PDF]

, 2007
BACKGROUND: Reduction or elimination of vector populations will tend to reduce or eliminate transmission of vector-borne diseases. One potential method for environmentally-friendly, species-specific population control is the Sterile Insect Technique (SIT)
Epton Matthew J, Gavin Pape, Guoliang Fu, Phuc, HK, Coleman Paul G, Burton, RS, Fu, G, Pape, G, Kirsty C Condon, Paul G Coleman, Fu, Guoliang, Phuc Hoang, Donnelly, CA, Coleman, Paul G, Andreasen, Morten H, Burton Rosemary S, Fu Guoliang, Pape, Gavin, Donnelly Christl A, White-Cooper, Helen, Scaife Sarah, Donnelly, Christl A, Coleman, PG, White-Cooper, H, White-Cooper Helen, Scaife, Sarah, Vass, Céline, Condon, Kirsty C, Phuc, Hoang Kim, Alphey, Luke, Andreasen, MH, Sarah Scaife, Luke Alphey, Condon, KC, Condon Kirsty C, Céline Vass, Scaife, S, Alphey, L, Helen White-Cooper, Christl A Donnelly, Vass Céline, Alphey Luke, Vass, C, Rosemary S Burton, Pape Gavin, Hoang Phuc, Epton, MJ, Epton, Matthew J, Burton, Rosemary S, Andreasen Morten H, Morten H Andreasen, Matthew J Epton   +51 more
core   +1 more source

Hyperactive ice‐binding proteins stabilize cell membranes and improve resistance to dehydration stress in Caenorhabditis elegans

FEBS Open Bio, EarlyView.
TisIBP8, a fungal‐derived hyperactive ice‐binding protein, helps Caenorhabditis elegans survive dehydration. It localizes near cell membranes, reduces cell damage, and helps maintain membrane structure during drying. These results suggest that ice‐binding proteins can protect cells from dehydration stress as well as freezing stress.
Daiki Shimose, Kotaro Ozaki, Ryohei Kuriyama, Yuka Ikemoto, Kazuhiro Mio, Yuji C. Sasaki, Tatsuya Arai, Sakae Tsuda, Yoichi Shinkai, Masahiro Kuramochi   +9 more
wiley   +1 more source

Unmet Medical Needs in Non-Small-Cell Lung Cancer Treatment: How to Design Pre-Emptive Combination Therapies [PDF]

European Medical Journal Oncology, 2014
The rapidly expanding catalogue of human oncogenic mutations, coupled with difficulties in identifying the cellular targets of active compounds in phenotypic screens, has refocused drug discovery efforts on inhibitors of specific cellular proteins.
Niki Karachaliou, Rafael Rosell
doaj  

Species and strain differences in the lethal factor of the mouse submandibular gland

, 1977
The differences in susceptibility of animals to the lethal factor extracted from the mouse submandibular gland and magnitude of its lethality were compared among various species, strains, ages, and sex of mice.
Y. T. Kim, K. Hoshino, J. C.-C. Huang, F. S. Chebib   +3 more
core   +1 more source

Molecular characterization of covRS mutations in M1UK Streptococcus pyogenes

FEBS Open Bio, EarlyView.
Group A Streptococcus (GAS) acquires covRS mutations driving a hypervirulent bacterial state, frequently associated with invasive disease‐like necrotizing fasciitis. We demonstrate that the newly emerged M1UK GAS lineage can also acquire these mutations.
Jarrad Pritchard, Emma‐Jayne Proctor, Jiawa Wang, Nikolas P. Johnston, Andrew Hayes, Georgia McCorkell, Haibo Yu, Jai Tree, Mark R. Davies, Mark J. Walker, Ronald Sluyter, Stephan Brouwer, Martina L. Sanderson‐Smith   +12 more
wiley   +1 more source

Does Religiosity Predict Suicidal Behavior?

Religions, 2017
Research was reviewed on whether self-report measures of religiosity were a protective factor against suicidal behaviors. It was found that scores on Francis’s measure of religiosity was negatively associated with non-lethal suicidal behavior (ideation ...
David Lester
doaj   +1 more source

Characterization of Bacillus anthracis lethal factor [PDF]

, 2006
Anthrax lethal toxin (LeTx), consisting of protective antigen and lethal factor (LF), is a principal virulence factor of Bacillus anthracis. LF represents the enzymatic component of LeTx and its cytosolic targets are members of the mitogen activated ...
Ngai, Stephanie
core