Results 61 to 70 of about 17,950,531 (342)

Lethal Violence and Migration in Mexico: An Analysis of Internal and International Moves [PDF]

, 2020
We analyze the effect of homicide in Mexico on patterns and processes of internal and international migration. Linking municipal-level homicide rates from 1990 through 2018 with data from the Mexican Migration Project, we estimate a series of multinomial
Massey, Douglas S., Jorge Durand, Pren, Karen A., Durand, Jorge, Karen Pren, Douglas Massey   +5 more
core   +1 more source

Reciprocal control of viral infection and phosphoinositide dynamics

FEBS Letters, EarlyView.
Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley   +1 more source

Research on earthquake disaster risk based on the anti-lethal levels of buildings at the township level: a case study in Suqian, China

Geomatics, Natural Hazards & Risk
The assessment of earthquake disaster risk constitutes a fundamental basis for the rational allocation of disaster relief resources and the formulation of scientifically strategies for earthquake prevention and disaster mitigation.
Xihai Zhang, Ting Zhang, Dongchen Wang, Chen Wang, Nian Xu, Fei Gao, Yan Deng, Xiwei Fan   +7 more
doaj   +1 more source

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

FEBS Letters, EarlyView.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes, Guilherme M. Azevedo, Amanda P. Barcellos, Diana Bahia   +3 more
wiley   +1 more source

A Single Immunization with Soluble Recombinant Trimeric Hemagglutinin Protects Chickens against Highly Pathogenic Avian Influenza Virus H5N1

, 2010
Background: The highly pathogenic avian influenza (HPAI) virus H5N1 causes multi-organ disease and death in poultry, resulting in significant economic losses in the poultry industry.
Dep Infectieziekten Immunologie, Robert P de Vries, Vries, R.P., de, Rigter, A., Rottier, P.J.M., Cornelissen, A.H.M., de Vries, R.P., Cornelissen, L.A.H.M., Alan Rigter, Cornelis A M de Haan, Strategic Infection Biology, de Haan, C.A.M., Haan, C.A.M., de, de Boer-Luijtze, E.A., Boer-Luijtze, E.A., de, Lisette A H M Cornelissen, Els A de Boer-Luijtze, Peter J M Rottier   +17 more
core   +1 more source

Critical role of perforin-dependent CD8+ T cell immunity for rapid protective vaccination in a murine model for human smallpox [PDF]

, 2012
Vaccination is highly effective in preventing various infectious diseases, whereas the constant threat of new emerging pathogens necessitates the development of innovative vaccination principles that also confer rapid protection in a case of emergency ...
Gerd Sutter (181175), Majzoub Monir, Sutter Gerd, Kay-Martin Hanschmann (181170), Yasemin Suezer, Kalinke Ulrich, Suezer, Yasemin, Monir Majzoub (181167), Yasemin Suezer (181158), Hanschmann Kay-Martin, Theresa Frenz, Melanie Kremer (181155), Michael H. Lehmann (181173), Lehmann Michael H., Suezer Yasemin, Michael H. Lehmann, Volz Asisa, Asisa Volz (181161), Kay-Martin Hanschmann, Michael H Lehmann, Kremer, Melanie, Asisa Volz, Ulrich Kalinke, Hanschmann, Kay-Martin, Kremer Melanie, Kalinke, Ulrich, Theresa Frenz (181164), Monir Majzoub, Sutter, Gerd, Melanie Kremer, Frenz, Theresa, Ulrich Kalinke (41173), Frenz Theresa, Gerd Sutter, Lehmann, Michael H, Volz, Asisa, Majzoub, Monir, Lehmann, Michael H.   +37 more
core   +1 more source

An upstream open reading frame regulates expression of the mitochondrial protein Slm35 and mitophagy flux

FEBS Letters, EarlyView.
This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva, Ariann E. Mendoza‐Martínez, P. Abril Medina‐Flores, Carlos Campero‐Basaldua, Alexander DeLuna, Soledad Funes   +5 more
wiley   +1 more source

Lethal DNA lesions caused by direct and indirect actions of X-rays are repaired via different DSB repair pathways under aerobic and anoxic conditions

, 2021
We examined lethal damages of X-rays induced by direct and indirect actions, in terms of DSB repair susceptibility using two kinds of repair deficient Chinese hamster ovary (CHO) cell lines. These CHO mutants (51D1 and xrs6) are genetically deficient in
Koichi, Ando, 1008829, Ryoichi, Hirayama, 1008821, Atsushi, Ito, Yoshitaka, Matsumoto, 1008822, Motofumi, Suzuki, 1008823, 1008824, 1008825, 1008826, Akiko, Uzawa, 1008827, 1008828, 1008820, Li, Huizi, 1008818, 1008819, 1008832, 1008833, 1008834, 1008835, Ryuichi, Okayasu, 1008836, 1008815, 1008816, 1008817, Sumitaka, Hasegawa, 1008830, 1008831, Yoshiya, Furusawa, Miho, Noguchi   +32 more
core   +1 more source

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

FEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee, Dimitrios Bekiari, Sofia Doello, Karl Forchhammer   +3 more
wiley   +1 more source

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source