Results 181 to 190 of about 120,091 (334)

Loss of SOCS1 in Donor T Cells Exacerbates Intestinal GVHD by Driving a Chemokine‐Dependent Pro‐Inflammatory Immune Microenvironment

Advanced Science, EarlyView.
T cell‐specific Socs1 knockout leads to inflammatory differentiation of CD8+ T cells, prompting the STAT1/2 complex to drive the activation of Ccl5, Ccr5, and Cxcr3, and promoting the skewing of monocytes toward a pro‐inflammatory M1 macrophage lineage.
Zhigui Wu, Bixia Wang, Xinya Jiang, Fangqing Zhang, Qianqian Huang, Xinyi Wu, Shuang Fan, Qi Zhang, Jingrui Zhou, Jianing Tang, Xiao‐Dong Mo, Yu Wang, Ying‐Jun Chang, Huidong Guo, Xiao‐Jun Huang   +14 more
wiley   +1 more source

Anthrax lethal toxin disrupts the endothelial permeability barrier through blocking p38 signaling

, 2011
Tiegang Liu, Erica Milia, Rod R. Warburton, Nicholas S. Hill, Matthias Gaestel, Usamah S. Kayyali   +5 more
openalex   +2 more sources

Identification and Characterization of an In Silico Designed Membrane‐Active Peptide with Antiviral Properties

Advanced Science, EarlyView.
An evolutionary molecular dynamics platform is used to design P1.6, a membrane‐active peptide that senses lipid packing defects in viral envelopes. P1.6 adopts a stabilized α‐helical structure upon membrane contact, disrupts virus‐like liposomes, and damages HIV‐1 particles.
Pascal von Maltitz, Niek van Hilten, Tatjana Weil, Thunchanok Thummaraj, Jeroen Methorst, Dennis Aschmann, Alexander Kros, Clarissa Read, Jasmina Gačanin, Herre Jelger Risselada, Jan Münch   +10 more
wiley   +1 more source

Anthrax Toxin Uptake by Primary Immune Cells as Determined with a Lethal Factor-β-Lactamase Fusion Protein

, 2009
Haijing Hu, Stephen H. Leppla
openalex   +2 more sources

Anthrax Lethal and Edema Toxins Produce Different Patterns of Cardiovascular and Renal Dysfunction and Synergistically Decrease Survival in Canines [PDF]

, 2010
Daniel A Sweeney, Xizhong Cui, Steven B. Solomon, David Vitberg, Thi Migone, David M. Scher, Robert L. Danner, Charles Natanson, G. Mani Subramanian, Peter Q. Eichacker   +9 more
openalex   +1 more source

PDIA3 Inhibition Facilitates Sensitivity of IKE‐Induced Ferroptosis via STAT3/LCN2 Axis to Improve Glioblastoma Therapy

Advanced Science, EarlyView.
In this manuscript, protein disulfide isomerase A3 (PDIA3) is identified as a key factor mediating the susceptibility of ferroptosis in GBM. Inhibition of PDIA3 enhances IKE or cystine starvation‐induced ferroptosis in GBM cells by resulting in the accumulation of lipid peroxidation and a reduction in GSH level.
Jie Zhang, Wei Wang, Xin Liu, Peifen Lu, Xinjing Liu, Qiucheng Nie, Siyuan Xin, Hong Li, Donglin Yu, Xinyue Zhang, Kailong Li, Xiaomin Han, Shuping Zhang, Wei Chong, Lili Sun, Wei Li, Tao Xin, Jin Jiao, Qiang Ma, Yiju Wei   +19 more
wiley   +1 more source

Toxin neutralizing activity of monoclonal antibodies against Bacillus anthracis lethal toxin

Immunologiya, 2021
Ya.O. Romanenko, M.A. Marin, A.K. Riabko, A.S. Kartseva, M.V. Silkina, N.A. Zeninskaya, I.G. Shemyakin, I.A. Dyatlov, V.V. Firstova   +8 more
openaire   +2 more sources

Logic‐Gated HSV‐TK/GCV Suicide Gene Circuit for Triple‐Negative Breast Cancer

Advanced Science, EarlyView.
The BRAS comprises two modular genetic components driven by distinct tumor‐specific promoters and a failsafe layer with the NOT gate. This multi‐input logic gate circuit enables precise, specific expression of HSV‐TK in breast cancer cells with hardly expression in normal cell and effectively inhibits tumor growth in a triple‐negative breast cancer ...
Shasha Tang, Yuan Fang, Lingli Jin, Dongyang Liu, Yicheng Liu, Ruijia Zheng, Liyun Yong, Xin Wu, Longliang Qiao, Meiyan Wang, Fengfeng Cai   +10 more
wiley   +1 more source

Duration of tetanus IgG titres following basic immunisation of horses [PDF]

, 2015
Abrahamian, Descombey, Galen, Green, Heldens, Hendriksen, Jansen, Kay, Liefman, Liu, Löhrer, Scarnell, Shumacker, Smith, Sneath, Steinman, Thein, Wilson, Wilson   +18 more
core   +2 more sources

Assembly of anthrax toxin pore: Lethal‐factor complexes into lipid nanodiscs [PDF]

, 2013
Narahari Akkaladevi, L. Hinton‐Chollet, Hirotake Katayama, Julie L. Mitchell, L. Szerszen, S. Mukherjee, Edward P. Gogol, Brad L. Pentelute, R. John Collier, Mark T. Fisher   +9 more
openalex   +1 more source