Results 91 to 100 of about 316,536 (262)
Molecular Oncology, EarlyView.RNA profiling of circulating extracellular vesicles (EVs) from blood samples of men undergoing prostate biopsy identifies transcripts associated with clinically significant prostate cancer. Integrative analysis with public tumor datasets links EV‐derived gene signatures to tumor stage and progression‐free survival, highlighting CASP3, XRCC2, and RIT1 ...
Stefan Werner +14 more
wiley +1 more source
Myristoylated p110α Causes Embryonic Death Due to Developmental and Vascular Defects
Open Life Sciences, 2015 The phosphatidylinositol 3-kinase (PI3K) signaling pathway regulates many important cellular functions. The functional impact of deregulating the PIK3CA gene, encoding the p110α catalytic subunit of PI3K, is validated by frequent gain of function ...
Sheen Mee Rie +4 more
doaj +1 more source
Genomic Replikin Count Predicts Increased Lethality of Malaria [PDF]
, 2012 Genomic Replikin Counts predict both the increase and the decrease of lethality of ...
Elenore S. Bogoch, Samuel Bogoch
core +2 more sources
Overview of molecular signatures of senescence and associated resources: pros and cons
FEBS Open Bio, EarlyView.Cells can enter a stress response state termed cellular senescence that is involved in various diseases and aging. Detecting these cells is challenging due to the lack of universal biomarkers. This review presents the current state of senescence identification, from biomarkers to molecular signatures, compares tools and approaches, and highlights ...
Orestis A. Ntintas +6 more
wiley +1 more source
Pleiotropic and Novel Phenotypes in The \u3cem\u3eDrosophila\u3c/em\u3e Gut Caused by Mutation of \u3cem\u3eDrop-Dead\u3c/em\u3e [PDF]
, 2018 Normal gut function is vital for animal survival, and deviations from such function can contribute to malnutrition, inflammation, increased susceptibility to pathogens, diabetes, neurodegenerative diseases, and cancer.
Benske, Anika +6 more
core +1 more source
FEBS Open Bio, EarlyView.Clinical analysis reveals significant dysregulation of FGFRL1 in esophageal cancer (EC) patients. RNAi‐coupled next‐generation sequencing (NGS) and in vitro study reveal FGFRL1‐mediated EC progression via EMT, PI3K/Akt, and Notch pathways. Functional assays confirm its role in tumor growth, migration, and invasion.
Aprajita Srivastava +3 more
wiley +1 more source
“Smashing Into Crowds” -- An Analysis of Vehicle Ramming Attacks [PDF]
, 2019 Vehicle ramming attacks are not new. But since 2010 Jihadists have urged their use. Is this the wave of the future, or a terrorist fad? To answer this and other questions the authors expanded and updated the database used in their May 2018 MTI Security ...
Butterworth, Bruce R. +1 more
core +1 more source
FEBS Open Bio, EarlyView.CRISPRI‐mediated gene silencing and phenotypic exploration in nontuberculous mycobacteria. In this Research Protocol, we describe approaches to control, monitor, and quantitatively assess CRISPRI‐mediated gene silencing in M. smegmatis and M. abscessus model organisms.
Vanessa Point +7 more
wiley +1 more source
Cardiology service of the south federal region: problems and perspectives
Российский кардиологический журнал, 2006 The South Federal Region (SFR) is characterized by unfavorable demographic situation, reflecting general situation in the whole country. For 2004, disease incidence in SFR has increased by 8, 7 %, and disease prevalence - by 7, 8 %. Mortality was high in
L. I. Katelnitskaya
doaj
Distribution of endothelial cell protein C/activated protein C receptor (EPCR) during mouse embryo development. [PDF]
, 2002 The endothelial cell protein C receptor (EPCR) augments protein C activation by the thrombomodulin.thrombin complex. Deletion of the EPCR gene in mice has been reported to lead to embryonic lethality before embryonic day 10 (E10.0). To identify potential
Crawley, JT +3 more
core