Results 101 to 110 of about 202,850 (314)
FEBS Open Bio, EarlyView.CRISPRI‐mediated gene silencing and phenotypic exploration in nontuberculous mycobacteria. In this Research Protocol, we describe approaches to control, monitor, and quantitatively assess CRISPRI‐mediated gene silencing in M. smegmatis and M. abscessus model organisms.
Vanessa Point +7 more
wiley +1 more source
Cardiology service of the south federal region: problems and perspectives
Российский кардиологический журнал, 2006 The South Federal Region (SFR) is characterized by unfavorable demographic situation, reflecting general situation in the whole country. For 2004, disease incidence in SFR has increased by 8, 7 %, and disease prevalence - by 7, 8 %. Mortality was high in
L. I. Katelnitskaya
doaj
PARP inhibitors induce a senescence phenotype in non‐small cell lung carcinoma cell lines
FEBS Open Bio, EarlyView.Talazoparib is the most potent inducer of senescence among different PARP1 inhibitors in human NSCLC cells. In the absence of PARP, no senescence phenotype was observed, demonstrating that PARP1 is necessary for the induction of senescence by this inhibitor.
Camille Huart +7 more
wiley +1 more source
FEBS Open Bio, EarlyView.Matrix metalloproteinase‐9 (MMP9) drives ovarian cancer progression. Using MMP9‐null cells (M9‐KO) created from ovarian cancer cells, we found MMP9 loss did not block Epidermal Growth Factor (EGF)‐driven E‐cadherin dissolution or EMT but delayed and reduced EGF‐driven membrane protrusions. Transient MMP9 re‐expression drove membrane protrusion.
Claire Strauel +8 more
wiley +1 more source
FEBS Open Bio, EarlyView.Pharmacological inhibition of PERK in a DEN‐induced mouse model of liver cancer does not reduce tumor burden but alters cellular stress signaling. Despite blocking PERK activity, downstream stress responses, including CHOP expression, remain active, suggesting compensatory mechanisms within the unfolded protein response that may influence tumor ...
Ada Lerma‐Clavero +5 more
wiley +1 more source
FEBS Open Bio, EarlyView.KIF26B plays an important role in kidney development. We engineered mice lacking the C‐terminal region of KIF26B and found severe kidney defects, including bilateral renal agenesis, similar to full Kif26b knockout mice. The mutation disrupted nephron progenitor condensation and reduced Gdnf‐Wnt11 signaling, showing that the KIF26B C‐terminal region is ...
Yuta Yamamura +19 more
wiley +1 more source
Microbiology SpectrumKlebsiella pneumoniae is a significant healthcare-associated pathogen, notable for its diverse virulence and antibiotic resistance profiles. This study aimed to characterize the genotypic and phenotypic diversity of K.
María Guembe +9 more
doaj +1 more source
THE EFFECT OF LITHIUM ON ACUTE TOXICITY OF CARBAMAZEPINE IN MICE [PDF]
Acta Medica Iranica, 1997 The effects of chronic administration of lithium, on acute toxicity of carbamazepine (CBZ) in mate albino mice was studied and the LD50 values were determined from dose-probit curves.
M. Samini., A.R. Dehpour, K. Hajinabi
doaj
Testing the Impact of Road Network Connectivity on Criminal Lethality
, 2018 Increased road network connectivity has been linked to more positive outcomes among all health outcomes. Road network connectivity has yet to be tested in association with specifically criminal lethality.
Poole, Aaron C. +7 more
core +1 more source