Results 91 to 100 of about 202,850 (314)
Revista de Ciencias Médicas de Pinar del Río, 2011 Se realizó una investigación observacional, descriptiva, longitudinal y retrospectiva. El universo estuvo constituido por 95, 858 embarazadas y puérperas que acudieron al Hospital General Docente "Abel Santamaría Cuadrado" de Pinar del Río durante el ...
Olga María Prats Álvarez +4 more
doaj
Liquid biopsy‐based diagnostic evaluation of hypermethylated CpG sites for ovarian cancer diagnosis
Molecular Oncology, EarlyView.This schematic outlines the workflow from biomarker identification to duplex MethyLight assay validation for epithelial ovarian cancer diagnosis using cfDNA‐based liquid biopsy. Initial screening of hypermethylated CpG candidates (cg02957270, cg10061138 cg00480298, COL2A1) was performed in tissue using ARMS‐PCR, COBRA, qPCR and image analysis. Selected
Deepa Bisht +3 more
wiley +1 more source
Bacterial infections associated with hepatic encephalopathy: Prevalence and outcome
Annals of Hepatology, 2003 Hepatic encephalopathy (HE) is a major sign of severe liver disease and the impact of associated bacterial infectious should be better evaluated. A retrospective cohort of 333 patients with cirrhosis and HE was analyzed in three periods of time, from ...
Edna Strauss, M.D +1 more
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Prioritizing Strategic Cyberspace Lethality
, 2019 The primary concern of United States national security policy, as detailed in the 2018 National Defense Strategy, has shifted from asymmetrical counter-insurgency operations to countering inter-state strategic competition by rogue regimes and revisionist
Schoka, Andrew J.
core +1 more source
Weakening the nuclear envelope: Lamin B receptor in melanoma metastasis
Molecular Oncology, EarlyView.LBR‐driven nuclear fragility supports melanoma invasion. A: Melanocyte presents low LBR (Lamin B Receptor) levels, maintaining nuclear integrity and lamina‐chromatin tethering. B: During malignant progression, upregulation of LBR clusters at the INM (Inner Nuclear Membrane) during confined migration causes local lamina weakening and cholesterol ...
Francesca Lorenzini +1 more
wiley +1 more source
Frontiers in Cardiovascular MedicineBackgroundCardiovascular diseases (CVDs) remain the leading cause of mortality and morbidity in Europe. Understanding their burden is essential to planning effective public health responses.
Ilaria Valentini +7 more
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Molecular Oncology, EarlyView.Patient‐derived organoids (PDOs) from pancreatic, colorectal, and gastric cancers were used to evaluate standard and experimental therapies. Incorporating cancer‐associated fibroblasts (CAFs) into organoid cultures improved patient therapy outcome prediction.
Marcin Grochowski +12 more
wiley +1 more source
Myristoylated p110α Causes Embryonic Death Due to Developmental and Vascular Defects
Open Life Sciences, 2015 The phosphatidylinositol 3-kinase (PI3K) signaling pathway regulates many important cellular functions. The functional impact of deregulating the PIK3CA gene, encoding the p110α catalytic subunit of PI3K, is validated by frequent gain of function ...
Sheen Mee Rie +4 more
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Nature CommunicationsAbstract As heatwaves increase in both frequency and intensity globally, the need to develop tools to predict the human impact and develop a more comprehensive understanding of the impact mechanism at a population level is becoming more urgent.
Rouse, Robert Edwin +8 more
openaire +1 more source
, 2014 "The lethality of a H.E. shell or bomb depends on its ability to produce high velocity fragments and blast. The relative importance of these two damaging agents depends on the nature of the targets it is proposed to destroy.
Thiruvenkatachar, V. R.
core +1 more source