Results 81 to 90 of about 202,850 (314)
Molecular Oncology, EarlyView.We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu +10 more
wiley +1 more source
Frontiers in GeneticsDrosophila melanogaster has been at the forefront of genetic studies and biochemical modeling for over a century. Yet, the functions of many genes are still unknown, mainly because no phenotypic data are available.
Attila Cristian Ratiu +4 more
doaj +1 more source
Thermal Process Lethality Calculator (F-value)
, 2023 The paper presents two Python-based calculators for determining the F-value, a measure of the lethality of a thermal process in food safety. Utilizing both the Trapezoidal rule and Simpson's rule for numerical integration, the calculators compute the ...
Simoes
core +1 more source
Molecular Oncology, EarlyView.RNA profiling of circulating extracellular vesicles (EVs) from blood samples of men undergoing prostate biopsy identifies transcripts associated with clinically significant prostate cancer. Integrative analysis with public tumor datasets links EV‐derived gene signatures to tumor stage and progression‐free survival, highlighting CASP3, XRCC2, and RIT1 ...
Stefan Werner +14 more
wiley +1 more source
, 2008 Within the defence industry, there is the need to provide an improvement in the efficiency (performance) of a missile system. The present generation of missile systems are sub-optimal in many currently considered scenarios.
Patel, N.
core
Suicide Attempt Lethality in Bipolar Disorder
, 2022 Bipolar disorder is associated with greater suicide risk compared to major depressive disorder, but it is not clear what characteristics of this disorder contribute to increased risk.
Claflin, Bridget Veronica
core
Molecular Oncology, EarlyView.Here, we demonstrate that HS1BP3 interacts with Cortactin through a proline‐rich region (PRR3.1) and show that this interaction, and HS1BP3 itself, promote cancer cell proliferation and invasion. Inhibition of this interaction leads to build‐up of TKS5 in multivesicular endosomes and altered secretion of CD63 and CD9, providing an explanation for the ...
Arja Arnesen Løchen +9 more
wiley +1 more source
Calculating lethality risk avoidance
, 2009 This paper provides theoretical health-risk-assessment tools that are designed to facilitate planning for and managing radiological terrorism incidents that involve ingestion exposure to bone-seeking radionuclides (e.g., radiostrontium nuclides).
Scott, Bobby R
core
Assessment of lethality after treatments.
, 2013 Mice treated intraperitoneally (ip) and/or per oral (po) with vehicle (control), allopurinol (NL), probenecid (PB) and Crotalus durissus terrificus venom (vCdt) followed by NL (vCdt+NL) or PB (vCdt+PB) after 2 h.*Lethality at 24 h only differed in vCdt ...
Rodrigo Frezzatti (344802) +1 more
core +1 more source
Finding novel vulnerabilities of hypomorphic BRCA1 alleles
Molecular Oncology, EarlyView.Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder +10 more
wiley +1 more source