Results 61 to 70 of about 202,850 (314)
Lethal Mutations and Balanced Lethal Systems in Aspergillus nidulans [PDF]
Journal of General Microbiology, 1967 SUMMARY The frequency of spontaneous and ultraviolet-induced, recessive, lethal mutations was estimated in two diploid strains of Aspergillus nidulans. The parent diploids were heterozygous for recessive and semi-dominant markers ; each recessive lethal resulted in failure to recover haploid strains carrying the allele linked in coupling to that lethal.
J L, Azevedo, J A, Roper
openaire +2 more sources
Molecular Oncology, EarlyView.Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch +13 more
wiley +1 more source
Methodology to Perform Cyber Lethality Assessment
, 2017 The Naval Surface Warfare Center, Dahlgren Division (NSWCDD) Lethality and Effectiveness Branch is the Navy’s subject matter experts (SME) on target vulnerability, weapon lethality, and weapon effectiveness.
Zurasky, Matthew W.
core +1 more source
Molecular Oncology, EarlyView.We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric +10 more
wiley +1 more source
Revista Cubana de Medicina, 2005 Se sabe que la atención de pacientes asmáticos constituye un problema epidemiológico creciente que sobrecarga los servicios hospitalarios. Se realizó un estudio descriptivo mediante el análisis de series temporales (1995-2004) para describir la ...
Humberto Guanche Garcell +2 more
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Synergistic lethality between BRCA1 and H3K9me2 loss reflects satellite derepression. [PDF]
, 2019 has two histone H3 Lys9 methyltransferases, MET-2 (SETDB1 homolog) and SET-25 (G9a/SUV39H1 related). In worms, we found simple repeat sequences primarily marked by H3K9me2, while transposable elements and silent tissue-specific genes bear H3K9me3.
Gasser, Susan M +6 more
core +1 more source
Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer
Molecular Oncology, EarlyView.Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni +11 more
wiley +1 more source
CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3
Molecular Oncology, EarlyView.PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh +12 more
wiley +1 more source
The activity and lethality of militant groups:Ideology, capacity, and environment [PDF]
, 2013 What determines the activity and lethality of militant groups? To answer this question, a two-step count method disentangles activity and lethality in terms of ideology, capacity, and environmental factors. A first step assesses the determinants of group
Mierau, J.O. +2 more
core +3 more sources
COVID-19: Lessons learned [PDF]
Scripta Medica, 2020 Modern society has not forgotten yet epidemics that killed millions in the last millennium and the COVID-19 pandemic caused by the SARS CoV-2 has recently emerged.
Mijović Biljana
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