Results 51 to 60 of about 4,225,603 (282)

Circulating tumor cells in metastatic breast cancer patients treated with immune checkpoint inhibitors – a biomarker analysis of the ALICE and ICON trials

open access: yesMolecular Oncology, EarlyView.
In this explorative biomarker analysis, we assessed serial sampling of circulating tumor cells (CTCs) with CellSearch in two randomized trials testing immune checkpoint inhibitors (ICIs) in metastatic breast cancer. Our data demonstrate a prognostic potential of CTCs, most apparent 4 weeks into ICI therapy.
Nikolai Kragøe Andresen   +13 more
wiley   +1 more source

Bridging edition and corpus: a review of P. S. Post Scriptum: A Digital Archive of Ordinary Writing (Early Modern Portugal and Spain)

open access: yesRIDE, 2019
The project P. S. Post Scriptum (2012–2017) was aimed at the collection, edition, and analysis of Spanish and Portuguese private letters from the 16th to the early 19th century.
Ulrike Henny-Krahmer
doaj   +1 more source

Cell‐free and extracellular vesicle microRNAs with clinical utility for solid tumors

open access: yesMolecular Oncology, EarlyView.
Cell‐free microRNAs (cfmiRs) are small‐RNA circulating molecules detectable in almost all body biofluids. Innovative technologies have improved the application of cfmiRs to oncology, with a focus on clinical needs for different solid tumors, but with emphasis on diagnosis, prognosis, cancer recurrence, as well as treatment monitoring.
Yoshinori Hayashi   +6 more
wiley   +1 more source

The Discourse of Infatuation in John Keats’s Letters and Poems to Fanny Brawne

open access: yesAmerican and British Studies Annual, 2012
Seen from the vantage point of the Victorian sensibility, John Keats’s letters to Fanny Brawne transgress the norms of respectability,  being too personal, too passionate and too direct.
Malgorzata Łuczyńska-Hołdys
doaj  

Der Zürcher Sommer 1968: Die digitale Edition

open access: yesRIDE, 2014
Der Zürcher Sommer 1968 is a digital edition of the events in the late summer 1968. The edition is hosted by the University of Zurich. For the first time, various documents such as newspaper articles, wall newspapers, protocols of interrogation and other
Friederike Wein
doaj   +1 more source

Necessity or Unnecessary of writing Gemination in the Persian language [PDF]

open access: yesمطالعات زبانی و بلاغی, 2011
The plenty and variety of the Geminated Words indicates that certainly Gemination appears in the speech and speakers of the Persian language know this. The obvious reason is that Persian speakers whether young or old produce Gemination systematically and
آسیه ذبیح نیا عمران
doaj   +1 more source

Integrative analysis of circulating tumor cells (CTCs) and exosomes from small‐cell lung cancer (SCLC) patients: a comprehensive approach

open access: yesMolecular Oncology, EarlyView.
This study simultaneously investigated circulating tumor cells (CTCs) and exosomes from small‐cell lung cancer (SCLC) patients. The elevated expression of JUNB and CXCR4 in CTCs was a poor prognostic factor for SCLC patients, whereas exosomal overexpression of these biomarkers revealed a high discrimination ability of patients from healthy individuals,
Dimitrios Papakonstantinou   +13 more
wiley   +1 more source

MET variants with activating N‐lobe mutations identified in hereditary papillary renal cell carcinomas still require ligand stimulation

open access: yesMolecular Oncology, EarlyView.
MET variants in the N‐lobe of the kinase domain, found in hereditary papillary renal cell carcinoma, require ligand stimulation to promote cell transformation, in contrast to other RTK variants. This suggests that HGF expression in the microenvironment is important for tumor growth in such patients. Their sensitivity to MET inhibitors opens the way for
Célia Guérin   +14 more
wiley   +1 more source

Plasma lipidomic and metabolomic profiles in high‐grade glioma patients before and after 72‐h presurgery water‐only fasting

open access: yesMolecular Oncology, EarlyView.
Presurgery 72‐h fasting in GB patients leads to adaptations of plasma lipids and polar metabolites. Fasting reduces lysophosphatidylcholines and increases free fatty acids, shifts triglycerides toward long‐chain TGs and increases branched‐chain amino acids, alpha aminobutyric acid, and uric acid.
Iris Divé   +7 more
wiley   +1 more source

Sense-Making and Map-Making: War Letters as Personal Geographies

open access: yesNANO, 2014
Structured in three parts, this article will briefly review David Herman’s idea of “spatial reference” in narrative, particularly in epistolary form, and explain the research method used in this project; introduce military geographies and demonstrate how
Christina Knopf
doaj  

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