Results 301 to 310 of about 370,636 (381)

Transcriptomics-driven exploration of genetic variation and peptide discovery in the sea anemones Anthopleura midori and Actinia equina. [PDF]

Sci Rep
Zhang H, Pan X, Weigang C.
europepmc   +1 more source

Total Synthesis of the Membrane Spanning Tetraether Lipid brGDGT Ia and Elucidation of Its Stereochemical Configuration

Chemistry – A European Journal, EarlyView.
Branched glycerol dialkyl glycerol tetraethers (brGDGT's) are membrane‐spanning lipids produced by Acidobacteria, and used extensively in geochemistry as proxies. The first total synthesis of brGDGT Ia has been achieved, elucidating the relative stereochemical configuration of the methyl branches in the chain as syn.
Samarpita Mahapatra, Sebastian H. Kopf, Toby Halamka, Christian Merten, Deborah A. Drost, Adriaan J. Minnaard   +5 more
wiley   +1 more source

Context Dependency of Hydrophobicity in Intrinsically Disordered Proteins: Insights from a New Dewetting Free Energy-Based Hydrophobicity Scale. [PDF]

J Phys Chem B
Najafi S, Lobo S, Shell MS, Shea JE.
europepmc   +1 more source

Phosphorylation at the Helm: Kinase‐Mediated Regulation of Primary Cilia Assembly and Disassembly

Cytoskeleton, EarlyView.
ABSTRACT The primary cilium serves as an antenna of most vertebrate cells and is important for conveying cues from several signaling pathways into appropriate cellular responses during development and homeostasis. Cilia assembly and disassembly processes are thought to be strictly controlled; however, the precise nature of molecular events underlying ...
Andrea Lacigová, Lukáš Čajánek
wiley   +1 more source

Enhancing WRAP‐Based Nanoparticles for Small Interfering Ribonucleic Acid Delivery in pH‐Sensitive Environments

ChemMedChem, EarlyView.
PEGylation of the WRAP5‐based nanoparticles via acyl hydrazone linkers is achieved to obtain a pH‐sensitive small interfering ribonucleic acid‐targeted delivery. In acidic extracellular conditions (pH 5) occurring during myocardial ischemia‐reperfusion injury, this optimized delivery system is the only one showing efficient silence of the Fas ...
Giulia Di Gregorio, Coélio Vallée, Karidia Konate, Clémentine A. Teko‐Agbo, Thania Hammoum, Héloïse Faure‐Gautron, Yannick Bessin, Sebastien Deshayes, Eric Vivès, Albano C. Meli, Pascal de Santa Barbara, Sandrine Faure, Stéphanie Barrère‐Lemaire, Sébastien Ulrich, Prisca Boisguérin   +14 more
wiley   +1 more source

Changes of leucine-rich alpha 2 glycoprotein could be a marker of changes of endoscopic and histologic activity of ulcerative colitis. [PDF]

Sci Rep
Aoyama Y, Hiraoka S, Yasutomi E, Inokuchi T, Tanaka T, Takei K, Igawa S, Takeuchi K, Takahara M, Toyosawa J, Yamasaki Y, Kinugasa H, Kato J, Okada H, Otsuka M.   +14 more
europepmc   +1 more source

New pyridobenothiazolone derivatives display nanomolar pan‐serotype anti‐DENV activity

ChemMedChem, Accepted Article.
Dengue virus (DENV) serotypes 1–4 are mosquito‐borne flaviviruses that are responsible for significant morbidity and mortality worldwide, particularly in tropical and subtropical regions. Although two vaccines have been approved, their unbalanced efficacy across serotypes poses potential risks for specific populations.
Tommaso Felicetti, Chin Piaw Gwee, Kitti Wing Ki Chan, Giacomo Pepe, Ciro Milite, Pietro Campiglia, Satoru Watanabe, Muhammad Danial Bin Mohd Mazlan, Stefano Sabatini, Serena Massari, Oriana Tabarrini, Gianluca Sbardella, Subhash G. Vasudevan, Giuseppe Manfroni   +13 more
wiley   +1 more source

Pea and soy fortified with leucine stimulates muscle protein synthesis comparable to whey in a murine ageing model. [PDF]

Eur J Nutr
Dijk FJ, van Dijk M, Roberts J, van Helvoort A, Furber MJW.   +4 more
europepmc   +1 more source

Cellular Signaling of Amino Acid Metabolism in Prostate Cancer. [PDF]

Int J Mol Sci
Yao P, Cao S, Zhu Z, Wen Y, Guo Y, Liang W, Xie J.   +6 more
europepmc   +1 more source