Results 301 to 310 of about 545,233 (335)
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Experientia, 1981
Trypsin-catalyzed coupling of porcine desoctapeptide-insulin with synthetic octapeptides produced the [LeuB24]- (I), [LeuB25]- (II) and [LeuB24, LeuB25]- (III)analogues of human insulin. I, II and III displayed respectively 20--30%, 1--2% and 0.5% of the receptor binding activity of the normal hormone. Biological activities of these analogues seemed to
K, Inouye +5 more
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Trypsin-catalyzed coupling of porcine desoctapeptide-insulin with synthetic octapeptides produced the [LeuB24]- (I), [LeuB25]- (II) and [LeuB24, LeuB25]- (III)analogues of human insulin. I, II and III displayed respectively 20--30%, 1--2% and 0.5% of the receptor binding activity of the normal hormone. Biological activities of these analogues seemed to
K, Inouye +5 more
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Leucine kinetics at graded leucine intakes in young men
The American Journal of Clinical Nutrition, 1986A study was carried out with 12 young men to examine the relationships between the intake of leucine and indices of leucine kinetics, using L-[1-13C]leucine as a tracer. Six subjects received L-amino acid diets during 7-day periods supplying leucine in the range of 79 to 20 mg.kg-1.day-1 (Group I) and another six subjects (Group II) received leucine ...
M M, Meguid +5 more
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Addition of leucine precursors to the diet of leucine-starved mice
The American Journal of Clinical Nutrition, 1975Leucine-starved mice placed on a diet supplemented with the immediate precursor of leucine, alpha-ketoisocaproic acid, regain lost weight. This weight gain is similar to that observed when the leucine-starved mice are provided with leucine in their diet.
M E, Trigg +4 more
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Metabolism of leucine in fibroblasts with defects in the leucine catabolic pathway
International Journal of Biochemistry, 19871. The activity of the leucine catabolic pathway was measured by quantitation of the radiolabeled glutamic acid produced by intact cultured fibroblasts incubated with radiolabeled leucine. 2. Five normal cell lines produced an average of 179 +/- 47 pmol glutamic acid/mg cell protein/hr. 3.
T, Page, W L, Nyhan
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The Journal of Physical Chemistry B, 2023
For over two decades, peptide self-assembly has been the focus of attention and a great source of inspiration for biomedical and nanotechnological applications. The resulting peptide nanostructures and their properties are closely related to the information encoded within each peptide building block, their sequence, and their modes of self-organization.
Peter Divanach +4 more
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For over two decades, peptide self-assembly has been the focus of attention and a great source of inspiration for biomedical and nanotechnological applications. The resulting peptide nanostructures and their properties are closely related to the information encoded within each peptide building block, their sequence, and their modes of self-organization.
Peter Divanach +4 more
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New England Journal of Medicine, 1962
SPONTANEOUS hypoglycemia in infancy may, on rare occasions, be precipitated by the ingestion of casein, L-leucine or isovaleric acid, an intermediary metabolite of leucine.1 2 3 4 Recently, this phenomenon of "leucine-induced hypoglycemia" was observed to be associated with a rise in plasma insulin level.5 , 6 A case of leucine-induced hypoglycemia in ...
H M, HADDAD +3 more
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SPONTANEOUS hypoglycemia in infancy may, on rare occasions, be precipitated by the ingestion of casein, L-leucine or isovaleric acid, an intermediary metabolite of leucine.1 2 3 4 Recently, this phenomenon of "leucine-induced hypoglycemia" was observed to be associated with a rise in plasma insulin level.5 , 6 A case of leucine-induced hypoglycemia in ...
H M, HADDAD +3 more
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Leucine aminopeptase in the spleen
Experientia, 1962Leucinaminopeptidase wird histochemisch in der Milz von Mausen und Ratten untersucht. Eine besonders ausgepragte Reaktion zeigte sich in der Zentralarterienwandung und in den umgebenden Reticulumzellen der weissen Pulpa. Im Bereich der roten Pulpa verhalten sich nur die Inseln positiv, wahrend eine extramedullare Hamatopoese vorkommt.
L K, KORHONEN, S, RUPONEN
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Archives of Pediatrics & Adolescent Medicine, 1967
COCHRAN ET AL 1 in 1956 described a clinical condition characterized by hypoglycemic convulsions which were aggravated by a high protein diet. They noted that the leucine in the diet of these patients precipitated the episodes of hypoglycemia, whereas this did not occur when leucine was administered to unaffected individuals.
R, Snyder, A, Robinson
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COCHRAN ET AL 1 in 1956 described a clinical condition characterized by hypoglycemic convulsions which were aggravated by a high protein diet. They noted that the leucine in the diet of these patients precipitated the episodes of hypoglycemia, whereas this did not occur when leucine was administered to unaffected individuals.
R, Snyder, A, Robinson
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Effects of leucine, isoleucine, or threonine infusion on leucine metabolism in humans
American Journal of Physiology-Endocrinology and Metabolism, 1987Leucine and/or its alpha-keto acid, alpha-ketoisocaproate (KIC), have been reported to spare protein in humans. To determine whether specific amino acid infusions affect whole-body protein metabolism as estimated by changes in leucine flux and oxidation, five groups of normal subjects were infused with saline, leucine (0.47 and 0.94 mumol . kg-1 . min-
W F, Schwenk, M W, Haymond
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Glucocorticosteroids increase leucine oxidation and impair leucine balance in humans
American Journal of Physiology-Endocrinology and Metabolism, 1989High-dose glucocorticoid treatment results in protein wasting. To determine whether such therapy affects leucine oxidation in the postabsorptive state and the disposal of dietary amino acids, eight normal subjects were studied twice in random order, once after 5 days of prednisone (20 mg three times daily) and on a second occasion without prednisone as
B, Beaufrere +6 more
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