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Transcriptomic analysis of human primary T cells after short-term leucine-deprivation and evaluation of kinase GCN2's role in regulating differential gene expression. [PDF]
PLoS OneDougé A +6 more
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The truncated isoform of the receptor for hyaluronan-mediated motility (RHAMM<sup>Δ163</sup>) modulates shelterin and telomerase reverse transcriptase transcription affecting telomerase activity. [PDF]
Front AgingBasu K.
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Characterization of leucine-leucine transport in leaf tissues
Journal of Experimental Botany, 1996Uptake of the dipeptide [3H]Leu-Leu into leaf discs from mature broad bean (Vicia faba L.) was characterized. Uptake was maximal at pH 6.0 and appeared to be mediated by three systems with apparent Km values of 20 µM, 350 µM and 43 mM, respectively.
Andrée Bourbouloux +4 more
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Experientia, 1981
Trypsin-catalyzed coupling of porcine desoctapeptide-insulin with synthetic octapeptides produced the [LeuB24]- (I), [LeuB25]- (II) and [LeuB24, LeuB25]- (III)analogues of human insulin. I, II and III displayed respectively 20--30%, 1--2% and 0.5% of the receptor binding activity of the normal hormone. Biological activities of these analogues seemed to
T. Kanaya +5 more
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Trypsin-catalyzed coupling of porcine desoctapeptide-insulin with synthetic octapeptides produced the [LeuB24]- (I), [LeuB25]- (II) and [LeuB24, LeuB25]- (III)analogues of human insulin. I, II and III displayed respectively 20--30%, 1--2% and 0.5% of the receptor binding activity of the normal hormone. Biological activities of these analogues seemed to
T. Kanaya +5 more
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Leucine kinetics at graded leucine intakes in young men
The American Journal of Clinical Nutrition, 1986A study was carried out with 12 young men to examine the relationships between the intake of leucine and indices of leucine kinetics, using L-[1-13C]leucine as a tracer. Six subjects received L-amino acid diets during 7-day periods supplying leucine in the range of 79 to 20 mg.kg-1.day-1 (Group I) and another six subjects (Group II) received leucine ...
Vernon R. Young +5 more
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Addition of leucine precursors to the diet of leucine-starved mice
The American Journal of Clinical Nutrition, 1975Leucine-starved mice placed on a diet supplemented with the immediate precursor of leucine, alpha-ketoisocaproic acid, regain lost weight. This weight gain is similar to that observed when the leucine-starved mice are provided with leucine in their diet.
Michael E. Trigg +4 more
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Metabolism of leucine in fibroblasts with defects in the leucine catabolic pathway
International Journal of Biochemistry, 19871. The activity of the leucine catabolic pathway was measured by quantitation of the radiolabeled glutamic acid produced by intact cultured fibroblasts incubated with radiolabeled leucine. 2. Five normal cell lines produced an average of 179 +/- 47 pmol glutamic acid/mg cell protein/hr. 3.
William L. Nyhan, Theodore Page
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New England Journal of Medicine, 1962
SPONTANEOUS hypoglycemia in infancy may, on rare occasions, be precipitated by the ingestion of casein, L-leucine or isovaleric acid, an intermediary metabolite of leucine.1 2 3 4 Recently, this phenomenon of "leucine-induced hypoglycemia" was observed to be associated with a rise in plasma insulin level.5 , 6 A case of leucine-induced hypoglycemia in ...
Heskel M. Haddad +3 more
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SPONTANEOUS hypoglycemia in infancy may, on rare occasions, be precipitated by the ingestion of casein, L-leucine or isovaleric acid, an intermediary metabolite of leucine.1 2 3 4 Recently, this phenomenon of "leucine-induced hypoglycemia" was observed to be associated with a rise in plasma insulin level.5 , 6 A case of leucine-induced hypoglycemia in ...
Heskel M. Haddad +3 more
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