Results 281 to 290 of about 639,233 (341)
Structural basis for leucine sensing by the Sestrin2-mTORC1 pathway
Science, 2016 Robert A Saxton +2 more
exaly +2 more sources
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Association of NOD2 leucine-rich repeat variants with susceptibility to Crohn's disease
Nature, 2001Jean-Pierre Hugot +2 more
exaly +2 more sources
New England Journal of Medicine, 1962
SPONTANEOUS hypoglycemia in infancy may, on rare occasions, be precipitated by the ingestion of casein, L-leucine or isovaleric acid, an intermediary metabolite of leucine.1 2 3 4 Recently, this phenomenon of "leucine-induced hypoglycemia" was observed to be associated with a rise in plasma insulin level.5 , 6 A case of leucine-induced hypoglycemia in ...
H M, HADDAD +3 more
openaire +2 more sources
SPONTANEOUS hypoglycemia in infancy may, on rare occasions, be precipitated by the ingestion of casein, L-leucine or isovaleric acid, an intermediary metabolite of leucine.1 2 3 4 Recently, this phenomenon of "leucine-induced hypoglycemia" was observed to be associated with a rise in plasma insulin level.5 , 6 A case of leucine-induced hypoglycemia in ...
H M, HADDAD +3 more
openaire +2 more sources
On the Particle Formation of Leucine in Spray Drying of Inhalable Microparticles.
International journal of pharmaceutics, 2020The particle formation of L-leucine, a dispersibility-enhancing amino acid used in the spray drying of inhalable pharmaceutical aerosols, was extensively studied using three experimental methods, and the results were interpreted with the aid of theory. A
Mani Ordoubadi +8 more
semanticscholar +1 more source
Leucyl-tRNA Synthetase Is an Intracellular Leucine Sensor for the mTORC1-Signaling Pathway
Cell, 2012 Jung Min Han +2 more
exaly +2 more sources
Proceedings of the National Academy of Sciences of the United States of America
Significance This study showed that high-fat diet (HFD)-related gut microbiota produces leucine to promote cancer progression by activating polymorphonuclear myeloid-derived suppressor cell (PMN-MDSC) production in breast cancer and melanoma models.
Jiewen Chen +12 more
semanticscholar +1 more source
Significance This study showed that high-fat diet (HFD)-related gut microbiota produces leucine to promote cancer progression by activating polymorphonuclear myeloid-derived suppressor cell (PMN-MDSC) production in breast cancer and melanoma models.
Jiewen Chen +12 more
semanticscholar +1 more source
Archives of Pediatrics & Adolescent Medicine, 1967
COCHRAN ET AL 1 in 1956 described a clinical condition characterized by hypoglycemic convulsions which were aggravated by a high protein diet. They noted that the leucine in the diet of these patients precipitated the episodes of hypoglycemia, whereas this did not occur when leucine was administered to unaffected individuals.
R, Snyder, A, Robinson
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COCHRAN ET AL 1 in 1956 described a clinical condition characterized by hypoglycemic convulsions which were aggravated by a high protein diet. They noted that the leucine in the diet of these patients precipitated the episodes of hypoglycemia, whereas this did not occur when leucine was administered to unaffected individuals.
R, Snyder, A, Robinson
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Characterization of leucine-leucine transport in leaf tissues
Journal of Experimental Botany, 1996Uptake of the dipeptide [3H]Leu-Leu into leaf discs from mature broad bean (Vicia faba L.) was characterized. Uptake was maximal at pH 6.0 and appeared to be mediated by three systems with apparent Km values of 20 µM, 350 µM and 43 mM, respectively.
A, Jamaï +4 more
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Experientia, 1981
Trypsin-catalyzed coupling of porcine desoctapeptide-insulin with synthetic octapeptides produced the [LeuB24]- (I), [LeuB25]- (II) and [LeuB24, LeuB25]- (III)analogues of human insulin. I, II and III displayed respectively 20--30%, 1--2% and 0.5% of the receptor binding activity of the normal hormone. Biological activities of these analogues seemed to
K, Inouye +5 more
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Trypsin-catalyzed coupling of porcine desoctapeptide-insulin with synthetic octapeptides produced the [LeuB24]- (I), [LeuB25]- (II) and [LeuB24, LeuB25]- (III)analogues of human insulin. I, II and III displayed respectively 20--30%, 1--2% and 0.5% of the receptor binding activity of the normal hormone. Biological activities of these analogues seemed to
K, Inouye +5 more
openaire +2 more sources
Leucine kinetics at graded leucine intakes in young men
The American Journal of Clinical Nutrition, 1986A study was carried out with 12 young men to examine the relationships between the intake of leucine and indices of leucine kinetics, using L-[1-13C]leucine as a tracer. Six subjects received L-amino acid diets during 7-day periods supplying leucine in the range of 79 to 20 mg.kg-1.day-1 (Group I) and another six subjects (Group II) received leucine ...
M M, Meguid +5 more
openaire +2 more sources