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Sestrin mediates detection of and adaptation to low-leucine diets in Drosophila
Nature, 2022 Xin Gu, Patrick Jouandin, Michael A Reid
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Zonated leucine sensing by Sestrin-mTORC1 in the liver controls the response to dietary leucine
Science, 2022 The mechanistic target of rapamycin complex 1 (mTORC1) kinase controls growth in response to nutrients, including the amino acid leucine. In cultured cells, mTORC1 senses leucine through the leucine-binding Sestrin proteins, but the physiological ...
Andrew Cangelosi +2 more
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SAR1B senses leucine levels to regulate mTORC1 signalling
Nature, 2021Jie Chen, Peng R Chen, Ying Liu
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Sestrin2 is a leucine sensor for the mTORC1 pathway
Science, 2016 Lynne Chantranupong +2 more
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SIRT4 Is a Lysine Deacylase that Controls Leucine Metabolism and Insulin Secretion
Cell Metabolism, 2017 Frank K Huynh +2 more
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Leucine as an excipient in spray dried powder for inhalation.
Drug Discovery Today, 2021Leucine is a promising excipient with several applications in the development of inhalable spray-dried powder of high- and low-dose drugs. The addition of leucine has exhibited significant enhancing effects on the aerosolization and physical stability of
Nasser Alhajj +2 more
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