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The Journal of Physical Chemistry B, 2023
For over two decades, peptide self-assembly has been the focus of attention and a great source of inspiration for biomedical and nanotechnological applications. The resulting peptide nanostructures and their properties are closely related to the information encoded within each peptide building block, their sequence, and their modes of self-organization.
Peter Divanach +4 more
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For over two decades, peptide self-assembly has been the focus of attention and a great source of inspiration for biomedical and nanotechnological applications. The resulting peptide nanostructures and their properties are closely related to the information encoded within each peptide building block, their sequence, and their modes of self-organization.
Peter Divanach +4 more
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Metabolic Mechanism for l-Leucine-Induced Metabolome To Eliminate Streptococcus iniae.
Journal of Proteome Research, 2017Crucial metabolites that modulate hosts' metabolome to eliminate bacterial pathogens have been documented, but the metabolic mechanisms are largely unknown.
Chao-chao Du +6 more
semanticscholar +1 more source
Structure of the leucine zipper
Current Biology, 1992In the basic-region leucine-zipper domain, flexible DNA-binding arms are juxtaposed by a two-stranded, parallel coiled-coil motif called the leucine zipper. Genetic, physical and structural studies of the leucine zipper identify interactions that help determine the stability and specificity of dimerization and DNA binding.
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A switch between two-, three-, and four-stranded coiled coils in GCN4 leucine zipper mutants.
Science, 1993Coiled-coil sequences in proteins consist of heptad repeats containing two characteristic hydrophobic positions. The role of these buried hydrophobic residues in determining the structures of coiled coils was investigated by studying mutants of the GCN4 ...
P. Harbury +3 more
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Archives of Pediatrics & Adolescent Medicine, 1967
COCHRAN ET AL 1 in 1956 described a clinical condition characterized by hypoglycemic convulsions which were aggravated by a high protein diet. They noted that the leucine in the diet of these patients precipitated the episodes of hypoglycemia, whereas this did not occur when leucine was administered to unaffected individuals.
R. D. Snyder, A. Robinson
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COCHRAN ET AL 1 in 1956 described a clinical condition characterized by hypoglycemic convulsions which were aggravated by a high protein diet. They noted that the leucine in the diet of these patients precipitated the episodes of hypoglycemia, whereas this did not occur when leucine was administered to unaffected individuals.
R. D. Snyder, A. Robinson
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X-ray structure of the GCN4 leucine zipper, a two-stranded, parallel coiled coil.
Science, 1991The x-ray crystal structure of a peptide corresponding to the leucine zipper of the yeast transcriptional activator GCN4 has been determined at 1.8 angstrom resolution.
E. O’Shea +3 more
semanticscholar +1 more source
Glucocorticosteroids increase leucine oxidation and impair leucine balance in humans
American Journal of Physiology-Endocrinology and Metabolism, 1989High-dose glucocorticoid treatment results in protein wasting. To determine whether such therapy affects leucine oxidation in the postabsorptive state and the disposal of dietary amino acids, eight normal subjects were studied twice in random order, once after 5 days of prednisone (20 mg three times daily) and on a second occasion without prednisone as
B. Beaufrere +6 more
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Nature Structural Biology, 1996
Several proteins have recently been found to consist of repetitive structural units in a superhelical arrangement. The structure of the leucine-rich repeat variant protein represents an unexpected addition to the list of such proteins, with the repetitive unit consisting of antiparallel alpha- and 3(10)-helices.
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Several proteins have recently been found to consist of repetitive structural units in a superhelical arrangement. The structure of the leucine-rich repeat variant protein represents an unexpected addition to the list of such proteins, with the repetitive unit consisting of antiparallel alpha- and 3(10)-helices.
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Effects of leucine, isoleucine, or threonine infusion on leucine metabolism in humans
American Journal of Physiology-Endocrinology and Metabolism, 1987Leucine and/or its alpha-keto acid, alpha-ketoisocaproate (KIC), have been reported to spare protein in humans. To determine whether specific amino acid infusions affect whole-body protein metabolism as estimated by changes in leucine flux and oxidation, five groups of normal subjects were infused with saline, leucine (0.47 and 0.94 mumol . kg-1 . min-
Morey W. Haymond, W. F. Schwenk
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New England Journal of Medicine, 1965
In 1956 Cochrane et al.1 first reported that the hypoglycemia of some infants with "idiopathic familial hypoglycemia" was sharply accentuated by the oral administration of L-leucine. Their observation has been confirmed many times,2,3 although most investigators have found that only one quarter to one third of children with "idiopathic hypoglycemia ...
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In 1956 Cochrane et al.1 first reported that the hypoglycemia of some infants with "idiopathic familial hypoglycemia" was sharply accentuated by the oral administration of L-leucine. Their observation has been confirmed many times,2,3 although most investigators have found that only one quarter to one third of children with "idiopathic hypoglycemia ...
openaire +3 more sources