Microbial Biotechnology, Volume 17, Issue 10, October 2024.The yields of antimicrobial compounds, such as surfactin, fengycin, shikimic acid, and myriocin, increased or were observed in the optimized fermentation CFS. In conclusion, fermentation conditions improved the antifungal activity of the LZN01 strain and influenced the expression of genes involved in the synthesis of antimicrobial compounds.
Jiale Hu, Zhigang Wang, Weihui Xu
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, 2007 dissertationMacrolide antibiotics, which are N-demethylated, may generate a metabolite which binds to cytochrome P-450 (P-450) forming a metabolic-intermediate (MI) complex.
Pershing, Lynn Marie Kennard
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The Synthesis of the Macrolide Antibiotic (+/-)-Pyrenophorin [PDF]
, 1973 The synthesis of the macrolide antibiotic (+/-)-pyrenophorin (1) is described. The molecular sieve promoted cyclisation of the hydroxy methyl ester (135) failed in our hands but the hydroxy-acid (190) was successfully converted to the dithioacetal of (1)
Purcell, Thomas Andrew
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Synthetic Approaches to Medium and Large Rings [PDF]
, 1974 Synthetic routes to macrocyclic ketones and lactones via fused bicyclic, doubly bridged tricyclic and bridged tricyclic precursors have been investigated as follows : (a) The condensation of diethylsuccinylsuccinate and acrolein gave two interesting ...
Kennedy, William Brian
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Investigation of amorphous solid-state forms of spiramycin and clarithromycin [PDF]
, 2017 PhD (Pharmaceutics), North-West University, Potchefstroom Campus, 2017Recent studies have shown OIs remain a significant cause of approximately 90% of the morbidity and mortality in PLHIV even in the era of HAART.
Katsidzira, Runako Masline
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Computing Network of Diseases and Pharmacological Entities through the Integration of Distributed Literature Mining and Ontology Mapping [PDF]
, 2011 The proliferation of -omics (such as, Genomics, Proteomics) and -ology (such as, System Biology, Cell Biology, Pharmacology) have spawned new frontiers of research in drug discovery and personalized medicine.
Faisal, Fazle Elahi
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Exploration of the Diverse Functions of Cytochrome P450 Monooxygenases Towards the Development of Biocatalysts. [PDF]
, 2013 The superfamily of cytochrome P450 monooxygenases is involved in diverse oxidative processes including xenobiotic detoxification, steroid synthesis, and biosynthetic tailoring of diverse secondary metabolites.
Chiou, Karoline C.
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Functional insights into ABC-F proteins that mediate antibiotic resistance in Gram-positive bacteria [PDF]
, 2015 Members of the ABC-F subfamily of ATP-binding cassette (ABC) proteins mediate resistance to a broad array of clinically-important antibiotic classes that target the ribosome of Gram-positive pathogens.
Sharkey, Liam Karl Robert
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An Approach to Modify 14-Membered Lactone Macrolide Antibiotic Scaffolds. [PDF]
J Org Chem, 2022 Janas A +3 more
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Novel mechanisms of macrolide resistance revealed by in vitro selection and genome analysis in Mycoplasma pneumoniae. [PDF]
Front Cell Infect Microbiol, 2023 Wang N, Xu X, Xiao L, Liu Y.
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