Results 21 to 30 of about 16,120 (166)

Expansion and functional diversification of a leucyl aminopeptidase family that encodes the major protein constituents of Drosophila sperm [PDF]

BMC Genomics, 2011
Background The evolutionary diversification of gene families through gene creation (and loss) is a dynamic process believed to be critical to the evolution of functional novelty.
Karr Timothy L, Wilkin Elaine C, Dorus Steve   +2 more
doaj   +2 more sources

Biomarkers of oxidative stress, biochemical changes, and the activity of lysosomal enzymes in the livers of rainbow trout (Oncorhynchus mykiss Walbaum) vaccinated against yersiniosis before a Yersinia ruckeri challenge [PDF]

Journal of Veterinary Research
This study aimed to evaluate biomarkers of oxidative stress (2-thiobarbituric acid reactive substances, aldehyde and ketone derivatives of oxidatively modified proteins and total antioxidant capacity), the activity of antioxidant enzymes (superoxide ...
Kurhaluk Natalia, Grudniewska Joanna, Pękala-Safińska Agnieszka, Pajdak-Czaus Joanna, Terech-Majewska Elżbieta, Platt-Samoraj Aleksandra, Tkaczenko Halina   +6 more
doaj   +2 more sources

Leucyl and Cystinyl Aminopeptidase as a Prognostic-Related Biomarker in OV Correlating with Immune Infiltrates

Pharmacogenomics and Personalized Medicine, 2023
Qian Ma,1,* Lei Chang,2,* Wenwen Wang,2,* Lingyi Che,1 Xiaoqin Song,3 Gailing Li,2 Ying Zhang,2 Yibing Chen,1 Zhuoyu Gu,4 Xin Ge5 1Genetics and Prenatal Diagnosis Center, First Affiliated Hospital, Zhengzhou University, Zhengzhou, 450052 ...
Ma Q, Chang L, Wang W, Che L, Song X, Li G, Zhang Y, Chen Y, Gu Z, Ge X   +9 more
doaj   +3 more sources

Expression, Characterisation, Homology Modelling and Molecular Docking of a Novel M17 Family Leucyl-Aminopeptidase from Bacillus cereus CZ. [PDF]

Int J Mol Sci, 2023
Leucyl-aminopeptidase (LAP), an important metallopeptidase, hydrolyses amino acid residues from the N-terminus of polypeptides and proteins, acting preferentially on the peptide bond formed by N-terminus leucine.
Liu J, Cui T.
europepmc   +2 more sources

Isoforms of leucyl-aminopeptidase of Cerambyx cerdo (Coleoptera, Cerambycidae) larvae [PDF]

Archives of Biological Sciences, 2004
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Božić Nataša M., Vujčić Zoran M., Nenadović Vera A., Ivanović J.   +3 more
doaj   +5 more sources

The major leucyl aminopeptidase of Trypanosoma cruzi (LAPTc) assembles into a homohexamer and belongs to the M17 family of metallopeptidases. [PDF]

BMC Biochem, 2011
Background Pathogens depend on peptidase activities to accomplish many physiological processes, including interaction with their hosts, highlighting parasitic peptidases as potential drug targets.
Cadavid-Restrepo G, Gastardelo TS, Faudry E, de Almeida H, Bastos IM, Negreiros RS, Lima MM, Assumpção TC, Almeida KC, Ragno M, Ebel C, Ribeiro BM, Felix CR, Santana JM.   +13 more
europepmc   +2 more sources

Hemoglobin Digestion Genes Are Conserved in Lizard-Infective <i>Plasmodium</i> Species With Different Host Cellular Niches. [PDF]

Ecol Evol
Despite their evolutionary relatedness to malaria parasites that infect humans, wildlife Plasmodium—particularly those that infect birds and lizards—are understudied, leaving their vast genetic diversity to be explored. By assembling parasite transcriptomes from Plasmodium‐infected lizard blood, we provide the first evidence that lizard‐infective ...
Pangburn SJ, Borner J, Misra S, Zavalunova J, Perkins SL.   +4 more
europepmc   +2 more sources

Marine Invertebrates: A Promissory Still Unexplored Source of Inhibitors of Biomedically Relevant Metallo Aminopeptidases Belonging to the M1 and M17 Families

Marine Drugs, 2023
Proteolytic enzymes, also known as peptidases, are critical in all living organisms. Peptidases control the cleavage, activation, turnover, and synthesis of proteins and regulate many biochemical and physiological processes.
Isel Pascual Alonso, Fabiola Almeida García, Mario Ernesto Valdés Tresanco, Yarini Arrebola Sánchez, Daniel Ojeda del Sol, Belinda Sánchez Ramírez, Isabelle Florent, Marjorie Schmitt, Francesc Xavier Avilés   +8 more
doaj   +1 more source

KBE009: A Bestatin-Like Inhibitor of the Trypanosoma cruzi Acidic M17 Aminopeptidase with In Vitro Anti-Trypanosomal Activity

Life, 2021
Chagas disease, caused by the kinetoplastid parasite Trypanosoma cruzi, is a human tropical illness mainly present in Latin America. The therapies available against this disease are far from ideal. Proteases from pathogenic protozoan have been considered
Jorge González-Bacerio, Irina Arocha, Mirtha Elisa Aguado, Yanira Méndez, Sabrina Marsiccobetre, Maikel Izquierdo, Daniel G. Rivera, Katherine Figarella, Néstor L. Uzcátegui   +8 more
doaj   +1 more source

Purification of Advanced Therapeutics by Flow-Through Pseudo-Affinity Chromatography: Bi-Specific mABs, Fc Fusion Proteins, and Adeno-Associated Viruses. [PDF]

Biotechnol Bioeng
ABSTRACT Modern biopharmaceutical manufacturing requires purification platforms capable of processing structurally and functionally diverse products while addressing the challenge of removing persistent and high‐risk host cell proteins (HCPs).
Chu W, Barbieri E, Minzoni A, Shastry S, LeBarre JP, Shu Q, Williams T, Li X, Chandra D, Xu X, Bill J, Roush D, Taris J, Gilbert P, Kiesewetter A, Rammo O, Schulte M, Major C, Mouchahoir T, Cramer S, Boi C, Carbonell RG, Lenhoff A, Menegatti S.   +23 more
europepmc   +2 more sources