Results 21 to 30 of about 1,860 (145)

Development of an Assay to Distinguish Between Genotypes of the Leucyl-Cystinyl Aminopeptidase Gene

Re:GEN Open, 2022
Introduction: The leucyl-cystinyl aminopeptidase gene rs4869317 single nucleotide polymorphism (SNP) is associated with multiple conditions; for example, patients with the rs4869317 TT genotype experiencing septic shock have increased plasma clearance of vasopressin versus AA or AT genotypes.
Saji Vijayan
exaly   +3 more sources

Clathrins Are Involved in the Endocytosis of Host Cytosol in the Malaria Parasite. [PDF]

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This study characterized clathrin function in hemoglobin uptake from host red blood cells via the malaria parasite's specific endocytosis machinery, cytostome. Clathrin heavy chain, clathrin light chain, and AP‐1 γ subunit were found associated with certain proteins known to be involved in cytostome function, and they were localized at the collars of ...
Miao J, Lucky AB, Ning G, Xia X, Liang X, Siddiqui F, Min H, Wang C, Li X, Zhou ZH, Cui L.   +10 more
europepmc   +2 more sources

Grape Exosome-Like Nanovesicles Reverse the Prediabetic State in Mice. [PDF]

J Diabetes Res
Objective This research explored the effect of grape exosome–like nanovesicles (GELNs) on reversing prediabetic conditions in mice and investigated the underlying mechanisms via metabolomic and gut microbiota analyses. Methods Twenty‐four C57BL/6J mice were divided into four groups: normal control, prediabetic model, GELN intervention, and nutrient ...
Liu ZL, Cai SY, Qiayimaerdan A, Zunon Z, Yu YL, Ma XD.   +5 more
europepmc   +2 more sources

An unexpected role for leucyl aminopeptidase in UV tolerance revealed by a genome-wide fitness assessment in a model cyanobacterium [PDF]

Proceedings of the National Academy of Sciences of the United States of America, 2022
Arnaud Taton, Richard Szubin, Susan S Golden   +2 more
exaly   +2 more sources

Cloning, purification and preliminary crystallographic analysis of theHelicobacter pylorileucyl aminopeptidase–bestatin complex [PDF]

Acta Crystallographica Section F: Structural Biology Communications, 2013
Anna Roujeinikova
exaly   +2 more sources

Purification and characterization of leucyl aminopeptidase from the Todarodes pacificus hepatopancreas

Food Bioscience, 2023
Sang In Kang
exaly   +2 more sources

Marine Invertebrates: A Promissory Still Unexplored Source of Inhibitors of Biomedically Relevant Metallo Aminopeptidases Belonging to the M1 and M17 Families

Marine Drugs, 2023
Proteolytic enzymes, also known as peptidases, are critical in all living organisms. Peptidases control the cleavage, activation, turnover, and synthesis of proteins and regulate many biochemical and physiological processes.
Isel Pascual Alonso, Fabiola Almeida García, Mario Ernesto Valdés Tresanco, Yarini Arrebola Sánchez, Daniel Ojeda del Sol, Belinda Sánchez Ramírez, Isabelle Florent, Marjorie Schmitt, Francesc Xavier Avilés   +8 more
doaj   +1 more source

KBE009: A Bestatin-Like Inhibitor of the Trypanosoma cruzi Acidic M17 Aminopeptidase with In Vitro Anti-Trypanosomal Activity

Life, 2021
Chagas disease, caused by the kinetoplastid parasite Trypanosoma cruzi, is a human tropical illness mainly present in Latin America. The therapies available against this disease are far from ideal. Proteases from pathogenic protozoan have been considered
Jorge González-Bacerio, Irina Arocha, Mirtha Elisa Aguado, Yanira Méndez, Sabrina Marsiccobetre, Maikel Izquierdo, Daniel G. Rivera, Katherine Figarella, Néstor L. Uzcátegui   +8 more
doaj   +1 more source

Salt Priming as a Smart Approach to Mitigate Salt Stress in Faba Bean (Vicia faba L.)

Plants, 2022
The present investigation aims to highlight the role of salt priming in mitigating salt stress on faba bean. In the absence of priming, the results reflected an increase in H2O2 generation and lipid peroxidation in plants subjected to 200 mM salt shock ...
Amira K. Nasrallah, Mohamed A. M. Atia, Reem M. Abd El-Maksoud, Maimona A. Kord, Ahmed S. Fouad   +4 more
doaj   +1 more source

Urinary aminopeptidase activities as early and predictive biomarkers of renal dysfunction in cisplatin-treated rats. [PDF]

PLoS ONE, 2012
This study analyzes the fluorimetric determination of alanyl- (Ala), glutamyl- (Glu), leucyl-cystinyl- (Cys) and aspartyl-aminopeptidase (AspAp) urinary enzymatic activities as early and predictive biomarkers of renal dysfunction in cisplatin-treated ...
Andrés Quesada, Félix Vargas, Sebastián Montoro-Molina, Francisco O'Valle, María Dolores Rodríguez-Martínez, Antonio Osuna, Isabel Prieto, Manuel Ramírez, Rosemary Wangensteen   +8 more
doaj   +1 more source