Results 171 to 180 of about 253,634 (313)

Using flow cytometry for paediatric leukaemia diagnosis in Kenya: a protocol for mixed methods study. [PDF]

BMJ Open
Severance T, Lotodo T, Serem E, Njuguna F, Melly B, Orido M, Tonui R, Olbara G, Koima R, Kigen N, Kussick S, Ratliff V, Holl E, Monahan PO, Boova T, Vik T.   +15 more
europepmc   +1 more source

Targeting UXS1‐Dependent Glucuronate Detoxification Potentiates Metformin's Anti‐Tumor Efficacy in Lung Adenocarcinoma

Advanced Science, EarlyView.
This study reveals that metformin promotes glucuronic acid metabolism in lung adenocarcinoma by activating UGDH S476 phosphorylation and enhancing the conversion of UDPG to UDPGA based on metabolomics analysis. Through compound virtual screening, it is found that plantainoside targeting UGDH downstream UXS1 leads to UDPGA toxicity accumulation ...
Qihai Sui, Zhencong Chen, Guangyao Shan, Zhengyang Hu, Xing Jin, Jiaqi Liang, Yanjun Yi, Jiacheng Yin, Haochun Shi, Xifei Jiang, Junjie Xi, Zongwu Lin, Cheng Zhan, Fenghao Sun, Wei Jiang   +14 more
wiley   +1 more source

Single cell transcriptional evolution of myeloid leukemia of Down syndrome. [PDF]

Nat Commun
Trinh MK, Schuschel K, Issa H, Thomas R, Parks C, Oszlanczi A, Ogbonnah T, Zhou D, Mamanova L, Prigmore E, Robertson ER, Hodder A, Wenger A, Anderson ND, Whitfield HJ, Treger TD, Gonçalves-Dias J, Straathof K, O'Connor D, Young MD, Jardine L, Adams S, Klusmann JH, Bartram J, Behjati S.   +24 more
europepmc   +1 more source

CDK4/6 Inhibition Induces CD8+ T Cell Antitumor Immunity via MIF‐Induced Functional Orchestration of Tumor‐Associated Macrophages

Advanced Science, EarlyView.
CDK4/6 inhibition promotes CD8+ T cell expansion through tumor‐macrophage crosstalk by activating HIF‐1α and enhancing MIF‐CD44/CD74 signaling. This reprograms TAMs to boost MHC‐I antigen presentation, and CDK4/6 inhibitor‐trained M1 TAM supernatant therapy synergizes with low‐dose PD‐1 blockade to restore antitumor immunity.
Lin He, Yuzhong Peng, Lat‐lun Leong, Jingbo Zhou, Dongyang Tang, Weilu Wang, Xiaoran Wu, Josh haipeng Lei, Yongqin Ye, Yangyang Feng, Yunfeng Qiao, Xiangpeng Chu, Di Mu, Qi Zhao, Tzuming Liu, Yan Chen, Paul Kwonghang Tam, Chu‐Xia Deng   +17 more
wiley   +1 more source

Exploring the Role of Environmental Factors on Chromosomal Translocations Associated With Childhood Leukaemia. [PDF]

Cancer Med
Saville JR, Russell LJ, Padget K, McKay JA.   +3 more
europepmc   +1 more source

Leukaemia and unemployment [PDF]

Nature, 1991
openaire   +2 more sources

Phenylbutazone and Leukaemia [PDF]

BMJ, 1965
H. J. Woodliff, L. Dougan
openaire   +2 more sources

Natural Products Inspired Scaffold Diversification Leads to Unnatural Molecular Warhead and Covalent Strategy to Modulating Protein Function through Electrophilic Bromine Transfer

Advanced Science, EarlyView.
We report a new thiolate‐reactive α,α‐gem‐dibromo lactam warhead that activates transcription factor Nrf2 and demonstrates anti‐inflammatory activities, which have implications in cancer, neurodegeneration, and cardiovascular diseases. RNA‐seq illuminated detailed transcriptional profiles, and chemical reactions with cysteine‐containing compounds ...
Beau R. Brummel, Sofia Kokkaliari, Qiwen Gao, Jinjing Chen, Larissa Costa de Almeida, Srinivasarao Tenneti, Derek A. Leas, Eli Levit, Lewis S. Alexander, Khalil A. Abboud, Pingrong Wei, Michael D. Cameron, James R. Rocca, Ranjala Ratnayake, Donna D. Zhang, Hendrik Luesch, Robert W. Huigens III   +16 more
wiley   +1 more source

Water pollution and childhood leukaemia risk: a systematic review. [PDF]

Ecancermedicalscience
Nuñez-Enriquez JC, Medina-León D, Tinoco-Montejano D, Jacuinde-Trejo K, Flores-Lujano J, Gómez-Rivera L, Chávez-Martínez O, García-Alvarado FJ, Blanco-Padilla P, Pelayo R.   +9 more
europepmc   +1 more source

Fibrates Inhibit PLTP‐induced M2 Macrophage Infiltration and Increase the Sensitivity of Hepatocellular Carcinoma to ICIs

Advanced Science, EarlyView.
Phospholipid transfer protein(PLTP) plays a critical role in forming a complex with kinase A (AURKA) and P65. This interaction facilitates phosphorylation of P65 at Ser536, leading to the activation of the NF‐κB signaling pathway. Ultimately, this leads to the upregulation of downstream cytokines, including IL‐6, IL‐8, and CSF‐1, which promotes M2 ...
Xinyue Liang, Yaning Li, Jianxun Cai, Lisi Luo, Pengfei Yang, Yutong Chen, Jiancong Zhou, Yan Zeng, Jiaping Yu, Weiyu Zhang, Wenzheng Pang, Yufang Li, Chunhua Wen, Jian Li, Linjuan Zeng   +14 more
wiley   +1 more source