Results 1 to 10 of about 1,090,680 (369)

In vivo imaging enables high resolution preclinical trials on patients' leukemia cells growing in mice. [PDF]

, 2012
Xenograft mouse models represent helpful tools for preclinical studies on human tumors. For modeling the complexity of the human disease, primary tumor cells are by far superior to established cell lines.
Brentjens, Renier J., Castro Alves, Catarina, Ehrhardt, Harald, Farkasova, Katarina, Groiss, Volker, Horstmann, Martin, Jeremias, Irmela, Ogris, Manfred, Quintanilla-Martinez, Leticia, Schneider, Katja, Terziyska, Nadia, Wagner, Ernst, zur Stadt, Udo   +12 more
core   +6 more sources

Information-theoretic multi-time-scale partially observable systems with inspiration from leukemia treatment [PDF]

, 2022
We study a partially observable nonlinear stochastic system with unknown parameters, where the given time scales of the states and measurements may be distinct. The proposed setting is inspired by disease management, particularly leukemia.
arxiv   +1 more source

Epidemiology of leukemia and multiple myeloma in golestan, Iran [PDF]

, 2013
Background: The aim of this paper was to present the incidence rates of leukemia and multiple myeloma (MM) in Golestan province located in northeastern Iran during 2004-2009. Materials and Methods: This was a descriptive cross-sectional study.
Jahangirrad, A., Naeimi-Tabeie, M., Rajabli, N., Roshandel, G., Sedaghat, S.-M., Semnani, S.   +5 more
core   +1 more source

Rapid and label-free identification of single leukemia cells from blood in a high-density microfluidic trapping array by fluorescence lifetime imaging microscopy. [PDF]

, 2018
The rapid screening and isolation of single leukemia cells from blood has become critical for early leukemia detection and tumor heterogeneity interrogation. However, due to the size overlap between leukemia cells and the more abundant white blood cells (
Digman, Michelle A, Lee, Abraham P, Lee, Do-Hyun, Li, Xuan, Ma, Ning   +4 more
core   +1 more source

A Phase I study of Milademetan (DS3032b) in combination with low dose cytarabine with or without venetoclax in acute myeloid leukemia: Clinical safety, efficacy, and correlative analysis

Blood Cancer Journal, 2023
In TP53 wild-type acute myeloid leukemia (AML), inhibition of MDM2 can enhance p53 protein expression and potentiate leukemic cell apoptosis. MDM2 inhibitor (MDM2i) monotherapy in AML has shown modest responses in clinical trials but combining options of
Jayastu Senapati, Muharrem Muftuoglu, Jo Ishizawa, Hussein A. Abbas, Sanam Loghavi, Gautam Borthakur, Musa Yilmaz, Ghayas C. Issa, Samuel I. Dara, Mahesh Basyal, Li Li, Kiran Naqvi, Rasoul Pourebrahim, Elias J. Jabbour, Steven M. Kornblau, Nicholas J. Short, Naveen Pemmaraju, Guillermo Garcia-Manero, Farhad Ravandi, Joseph Khoury, Naval Daver, Hagop M. Kantarjian, Michael Andreeff, Courtney D. DiNardo   +23 more
doaj   +1 more source

Kernel Logistic Regression-linear for Leukemia Classification Using High Dimensional Data [PDF]

, 2009
Kernel Logistic Regression (KLR) is one of the statistical models that has been proposed for classification in the machine learning and data mining communities, and also one of the effective methodologies in the kernel–machine techniques.
Embong, A. (A), Purnami, S. W. (S), Rahayu, S. P. (S), Zain, J. M. (Jasni)   +3 more
core   +3 more sources

CREB is a critical regulator of normal hematopoiesis and leukemogenesis [PDF]

, 2008
The cAMP-responsive element binding protein (CREB) is a 43-kDa nuclear transcription factor that regulates cell growth, memory, and glucose homeostasis. We showed previously that CREB is amplified in myeloid leukemia blasts and expressed at higher levels
Akashi, Akashi, Bai, Bottazzi, Bruserud, Cheng, Christensen, Conkright, Crans-Vargas, Deepa B. Shankar, Dejah R. Judelson, Desdouets, Deshpande, Elliot M. Landaw, Fried, Fu, Hestdal, Impey, Ingrid Schmid, Jamieson, Jenny Chang, Jerry C. Cheng, Kathleen M. Sakamoto, Kentaro Kinjo, Kim, Kinjo, Kohn, Kondo, Koschmieder, Koya, Krishan, Kwon, Lee, Mayr, Mendoza, Miyoshi, Montminy, Ninomiya, Noriyuki Kasahara, Passegué, Ravi Bhatia, Rehemtulla, Renata Stripecke, Scherr, Shah, Shankar, Shankar, Shaywitz, Stripecke, Traver, Tuschl, Van Etten, Ventura, Winston S. Wu, Wong, Yuan   +55 more
core   +3 more sources

Generation of a poor prognostic chronic lymphocytic leukemia-like disease model: PKC subversion induces up-regulation of PKC II expression in B lymphocytes [PDF]

, 2015
Overwhelming evidence identifies the microenvironment as a critical factor in the development and progression of chronic lymphocytic leukemia, underlining the importance of developing suitable translational models to study the pathogenesis of the disease.
Cosimo, Emilio, Dunn, Karen, Gribben, John G., Holroyd, Ailsa, Mccaig, Alison M., McClanahan, Fabienne, Michie, Alison, Nakagawa, Rinako, Ramsay, Alan G., Tarafdar, Anuradha, Vukovic, Milica   +10 more
core   +3 more sources

miR-196b target screen reveals mechanisms maintaining leukemia stemness with therapeutic potential. [PDF]

, 2018
We have shown that antagomiR inhibition of miRNA miR-21 and miR-196b activity is sufficient to ablate MLL-AF9 leukemia stem cells (LSC) in vivo. Here, we used an shRNA screening approach to mimic miRNA activity on experimentally verified miR-196b targets
Aronow, Bruce J., Doench, John G., Grimes, H. Leighton, Lal, Ashish, Lieberman, Judy, McGlinn, Edwina, Meyer, Sara E., Morris, Patrick J., Muench, David E., Newkold, Tess J., O\u27Brien, Eric, Orr, Emily, Perentesis, John P., Rogers, Andrew M., Salomonis, Nathan, Thomas, Craig J.   +15 more
core   +2 more sources

Automated Detection of Acute Leukemia using K-mean Clustering Algorithm [PDF]

Advances in Intelligent Systems and Computing, vol 554. Springer, 2018, 2018
Leukemia is a hematologic cancer which develops in blood tissue and triggers rapid production of immature and abnormal shaped white blood cells. Based on statistics it is found that the leukemia is one of the leading causes of death in men and women alike.
arxiv   +1 more source